Coming home upset: Gender, marital satisfaction and the daily spillover of workday experience into couple interactions

This study explored how daily changes in workday pace and end-of-the-workday mood were related to nightly variations in withdrawn and angry marital behavior. For 3 days, 82 husbands and wives from 42 couples completed questionnaires at the end of the workday and at bedtime. More negatively arousing workdays were linked with angrier marital behavior for women and less angry and more withdrawn behavior for men. Daily changes in workday pace predicted fluctuations in women\u27s, but not men\u27s, marital behavior. Several of these workday-marital behavior connections varied by level of marital satisfaction. In contrast to the gender differences in responses to workday stress, no differences were found in typical marital behaviors. These findings suggest that gender differences are enhanced under stress

Coming home upset: Gender, marital satisfaction and the daily spillover of workday experience into couple interactions

This study explored how daily changes in workday pace and end-of-the-workday mood were related to nightly variations in withdrawn and angry marital behavior. For 3 days, 82 husbands and wives from 42 couples completed questionnaires at the end of the workday and at bedtime. More negatively arousing workdays were linked with angrier marital behavior for women and less angry and more withdrawn behavior for men. Daily changes in workday pace predicted fluctuations in women\u27s, but not men\u27s, marital behavior. Several of these workday-marital behavior connections varied by level of marital satisfaction. In contrast to the gender differences in responses to workday stress, no differences were found in typical marital behaviors. These findings suggest that gender differences are enhanced under stress

The economic implications of HLA matching in cadaveric renal transplantation.

Abstract Background: The potential economic effects of the allocation of cadaveric kidneys on the basis of tissue-matching criteria are controversial. We analyzed the economic costs associated with the transplantation of cadaveric kidneys with various numbers of HLA mismatches and examined the potential economic benefits of a local, as compared with a national, system designed to minimize HLA mismatches between donor and recipient in first cadaveric renal transplantations. Methods: All data were supplied by the U.S. Renal Data System. Data on all payments made by Medicare from 1991 through 1997 for the care of recipients of a first cadaveric renal transplant were analyzed according to the number of HLA-A, B, and DR mismatches between donor and recipient and the duration of cold ischemia before transplantation. Results: Average Medicare payments for renal-transplant recipients in the three years after transplantation increased from $60,436 per patient for fully HLA-matched kidneys (those with no HLA-A, B, or DR mismatches) to$80,807 for kidneys with six HLA mismatches between donor and recipient, a difference of 34 percent (P\u3c0.001). By three years after transplantation, the average Medicare payments were $64,119 for transplantations of kidneys with less than 12 hours of cold-ischemia time and$74,997 for those with more than 36 hours (P\u3c0.001). In simulations, the assignment of cadaveric kidneys to recipients by a method that minimized HLA mismatching within a local geographic area (i.e., within one of the approximately 50 organ-procurement organizations, which cover widely varying geographic areas) produced the largest cost savings ($4,290 per patient over a period of three years) and the largest improvements in the graft-survival rate (2.3 percent) when the potential costs of longer cold-ischemia time were considered. Conclusions: Transplantation of better-matched cadaveric kidneys could have substantial economic advantages. In our simulations, HLA-based allocation of kidneys at the local level produced the largest estimated cost savings, when the duration of cold ischemia was taken into account. No additional savings were estimated to result from a national allocation program, because the additional costs of longer cold-ischemia time were greater than the advantages of optimizing HLA matching

Habitat, Climate, and Raptors as Factors in the Northern Bobwhite Decline: A Multi-Scale Analysis

Landscape-level processes such as habitat loss and fragmentation are primarily responsible for the declines in northern bobwhite (Colinus virginianus). These landscape processes generally occur at a scale beyond that of traditional quail studies and may involve not only habitat loss and fragmentation but also broad-scale changes in climate trends and predation risk. However, reductions in usable space and changes in habitat configuration at smaller scales may also reduce population viability. It is therefore imperative to study relationships to bobwhite populations at multiple scales. The objective of our research is to quantify to what extent habitat loss and fragmentation, climate, and predators are affecting quail populations at multiple scales within Texas. Our study area will include the Rolling Plains and Rio Grande Plains ecoregions, which are historic strongholds of bobwhite, though each has seen recent declines. We will examine the relative contributions of 3 general factors (habitat, climate, and predators) on quail populations at multiple scales (ranch, route-level, and landscape). Specifically, these factors include total habitat amount, degree of fragmentation, raptor relative abundance, temperature, and precipitation. We will obtain data from multiple sources to determine quail trends (Breeding Bird Survey and ranch-level data) and relate habitat trends (National Land Cover Database and Texas Ecological Systems Classification Project), raptor abundance (Breeding Bird Survey), and climate factors (PRISM) within a multiple linear regression framework. This study will provide an understanding of 1) to what degree habitat loss and fragmentation are affecting quail populations on Texas rangelands, 2) how other factors such as climate and predators may be compounding these effects, and 3) how these relationships vary at multiple scales

Do (and say) as I say: Linguistic adaptation in human-computer dialogs

© Theodora Koulouri, Stanislao Lauria, and Robert D. Macredie. This article has been made available through the Brunel Open Access Publishing Fund.There is strong research evidence showing that people naturally align to each other’s vocabulary, sentence structure, and acoustic features in dialog, yet little is known about how the alignment mechanism operates in the interaction between users and computer systems let alone how it may be exploited to improve the efficiency of the interaction. This article provides an account of lexical alignment in human–computer dialogs, based on empirical data collected in a simulated human–computer interaction scenario. The results indicate that alignment is present, resulting in the gradual reduction and stabilization of the vocabulary-in-use, and that it is also reciprocal. Further, the results suggest that when system and user errors occur, the development of alignment is temporarily disrupted and users tend to introduce novel words to the dialog. The results also indicate that alignment in human–computer interaction may have a strong strategic component and is used as a resource to compensate for less optimal (visually impoverished) interaction conditions. Moreover, lower alignment is associated with less successful interaction, as measured by user perceptions. The article distills the results of the study into design recommendations for human–computer dialog systems and uses them to outline a model of dialog management that supports and exploits alignment through mechanisms for in-use adaptation of the system’s grammar and lexicon

Reviews

Christianity and the Detective Story. Ed. Anya Morlan and Walter Raubicheck. Reviewed by Melody Green. The Shamanic Odyssey: Homer, Tolkien, and the Visionary Experience Robert Tindall with Susana Bustos. Foreword by John Perkins. Reviewed by Emily E. Auger. Gaining a Face: The Romanticism of C.S. Lewis. James Prothero and Donald T. Williams. Reviewed by Crystal Hurd. The A-Z of C.S. Lewis: An Encyclopedia of His Life, Thought and Writings. Colin Duriez. Reviewed by Andrew Stout. Under The Mercy: Charles Williams & The Holy Grail. Robert Peirano. Reviewed by Eric Rauscher. Tolkien and the Modernists: Literary Responses to the Dark New Days of the 20th Century. Theresa Freda Nicolay. Reviewed by Robert T. Tally Jr. Tolkien at Exeter College: How an Oxford undergraduate Created Middle-Earth. John Garth. Reviewed by Mike Foster Fastitocalon: Studies in Fantasticism Ancient to Modern. Editors in Chief Thomas Honegger and Fanfan Chen. Reviewed by Janet Brennan Croft. TOLKIEN Studies XI Editors: Michael D.C. Drout, Verlyn Flieger, and David Bratman. Reviewed by Janet Brennan Croft

Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses.

OBJECTIVE To test the hypothesis that dimethyl fumarate (DMF, Tecfidera) elicits different biological changes from DMF combined with monoethyl fumarate (MEF) (Fumaderm, a psoriasis therapy), we investigated DMF and MEF in rodents and cynomolgus monkeys. Possible translatability of findings was explored with lymphocyte counts from a retrospective cohort of patients with MS. METHODS In rodents, we evaluated pharmacokinetic and pharmacodynamic effects induced by DMF and MEF monotherapies or in combination (DMF/MEF). Clinical implications were investigated in a retrospective, observational analysis of patients with MS treated with DMF/MEF (n = 36). RESULTS In rodents and cynomolgus monkeys, monomethyl fumarate (MMF, the primary metabolite of DMF) exhibited higher brain penetration, whereas MEF was preferentially partitioned into the kidney. In mice, transcriptional profiling for DMF and MEF alone identified both common and distinct pharmacodynamic responses, with almost no overlap between DMF- and MEF-induced differentially expressed gene profiles in immune tissues. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated oxidative stress response pathway was exclusively regulated by DMF, whereas apoptosis pathways were activated by MEF. DMF/MEF treatment demonstrated that DMF and MEF functionally interact to modify DMF- and MEF-specific responses in unpredictable ways. In patients with MS, DMF/MEF treatment led to early and pronounced suppression of lymphocytes, predominantly CD8+ T cells. In a multivariate regression analysis, the absolute lymphocyte count (ALC) was associated with age at therapy start, baseline ALC, and DMF/MEF dosage but not with previous immunosuppressive medication and sex. Furthermore, the ALC increased in a small cohort of patients with MS (n = 6/7) after switching from DMF/MEF to DMF monotherapy. CONCLUSIONS Fumaric acid esters exhibit different biodistribution and may elicit different biological responses; furthermore, pharmacodynamic effects of combinations differ unpredictably from monotherapy. The strong potential to induce lymphopenia in patients with MS may be a result of activation of apoptosis pathways by MEF compared with DMF

Reviews

The International Relations of Middle-earth: Learning from The Lord of the Rings. Abigail E. Ruane and Patrick James. Reviewed by Robert T. Tally Jr Moments of Grace and Spiritual Warfare in The Lord of the Rings. Anne Marie Gazzolo. Reviewed by Damien Bador. The Wizard of Oz as American Myth: A Critical Study of Six Versions of the Story, 1900-2007. Alissa Burger. Reviewed by Hugh H. Davis. Plain to the Inward Eye: Selected Essays on C.S. Lewis. Don W. King. Reviewed by Holly Ordway. Tolkien\u27s Poetry. Ed. Julian Eilmann and Allan Turner. Reviewed by Joe R. Christopher. The Lion\u27s World: A Journey into the Heart of Narnia. Rowan Williams. Reviewed by Melody Green. C. S. Lewis - A Life: Eccentric Genius, Reluctant Prophet. Alister McGrath. Reviewed by Gregory Bassham. Seven: An Anglo-American Literary Review. Ed. Marjorie Lamp Mead. Reviewed by Janet Brennan Croft. Supernatural Studies: Official Publication of the Supernatural Studies Association. Ed. Margo Collins and Deborah Christie. Reviewed by Janet Brennan Croft. Fastitocalon: Studies in Fantasticism Ancient to Modern. Ed. Thomas Honegger and Fanfan Chen. Reviewed by Janet Brennan Croft. Wormwood: Literature of the Fantastic, Supernatural and Decadent. Edited by Mark Valentine. Reviewed by Janet Brennan Croft

Geochronology of age-progressive volcanism of the Oregon High Lava Plains : implications for the plume interpretation of Yellowstone

The High Lava Plains province (HLP) is a late Cenozoic bimodal volcanic field at the northern margin of the Basin and Range province in southeastern Oregon that hosts a westward younging trend of silicic volcanism that crudely mirrors northeastward migration of silicic volcanism along the Yellowstone–Snake River Plain (YSRP) trend. We present ⁴⁰Ar/³⁹Ar ages for 19 rhyolite domes, 5 rhyolite ash flow tuffs, and 34 basaltic lavas from the HLP. The previously identified trend of westward migration of HLP rhyolites is confirmed. The rate of propagation is ∼33 km/m.y. from 10 to 5 Ma, slowing to ∼13 km/m.y. after 5 Ma. The duration of silicic volcanism at any locus is ∼2 m.y. Three older HLP dacite domes yielded ages of ∼15.5 Ma. Basalts are not age progressive. We identify several episodes of increased basaltic activity at 7.5–7.8, 5.3–5.9, and 2–3 Ma, with the younger episode likely continuing into the Recent. The HLP and YSRP trends emerged from the axis of middle Miocene basaltic volcanism of the Columbia River and Steens basalts. We propose a model in which (1) Miocene flood basalts and widespread silicic rocks are the result of emplacement of a plume head near the craton margin, enhanced by flow up a topographic gradient along the base of the lithosphere at the craton margin; (2) the HLP trend is the result of westward flow originating at the craton margin; and (3) the YSRP trend is the trace of the motion of the North American plate over the tail of the plume