Museus infantis : uma questão contemporânea

Esta dissertação consiste em um estudo sobre os museus infantis, buscando identificar e analisar um conjunto de questões contemporâneas que hoje participam do ambiente museal. Para a exploração das implicações arquitetônicas desta proposta museológica, foram selecionados três edifícios projetados para abrigar museus infantis: Kodomo no Yakata, de Tadao Ando, no Japão, Lied Discovery Children’s Museum, de Antoine Predock, nos Estados Unidos; e Papalote Museo del Niño, de Ricardo Legorreta, no México

Os espaços de exposição de Oscar Niemeyer em Brasília

Tese (doutorado)—Universidade de Brasília, Programa de Pesquisa e Pós-Graduação da Faculdade de Arquitetura e Urbanismo, 2013.Este trabalho visa aprofundar os estudos e a documentação pertinentes aos espaços de exposição projetados pelo arquiteto Oscar Niemeyer para Brasília. Nesta temática, compreendem-se museus, memoriais, monumentos e pavilhões realizados no período de aproximadamente cinquenta anos que vai de 1957 a 2008. Como subsídios para esta pesquisa, a primeira parte da tese refere-se às dimensões do objeto, compreendendo sua história, sua arquitetura e seus principais conceitos. De posse dessas informações, na segunda parte, analisam-se as obras relacionadas com exposições desenvolvidas pelo arquiteto ao longo da sua carreira na capital da república, buscando o entendimento do seu processo projetual. Para isso, recorreu-se a fontes primárias e à bibliografia referente a Oscar Niemeyer. _______________________________________________________________________________________ ABSTRACTThis work aims at delving deeper on studies and the documentation pertinent to the exhibition spaces designed by the architect Oscar Niemeyer for Brasilia. Museums, memorials, monuments and pavilions designed within a time span of nearly fifty years, from 1957 to 2008. As subsidy for this research, the first part of the thesis refers to the dimensions of the object, containing its history, architecture and main concepts. In possession of such information, in the second part, we analyzed works related to exhibitions developed by the architect throughout his career, in the capital of the Republic, seeking an understanding of his designing process. To accomplish these goals, primary sources and bibliography on Oscar Niemeyer were consulted

Reduction of gangliosides, phospholipids and cholesterol content in cerebral cortex of rats caused by chronic hypermethioninemia

Neurological dysfunction is observed in patients with severe hypermethioninemia, whose physiopathology is still poorly understood. In the current study we investigated the effect of chronic administration of methionine on the content and species of gangliosides and phospholipids, as well as on the concentration of cholesterol in rat cerebral cortex. Wistar rats received subcutaneous injections of methionine (1.34–2.68 μmol/g of body weight), twice a day, from the 6th to the 28th day of age and controls received saline. Animals were killed 12 h after the last injection. Results showed that methionine administration significantly decreased the total content of lipids in cerebral cortex of rats. We also observed that this amino acid significantly reduced the absolute quantity of the major brain gangliosides (GM1, GD1a, GD1b and GT1b) and phospholipids (sphingomyelin, phosphatidylcholine and phosphatidylethanolamine). We also showed that Na+,K+-ATPase activity and TBARS were changed in cerebral cortex of rats subjected to hypermethioninemia. If confirmed in human beings, these data could suggest that the alteration in lipid composition, Na+,K+-ATPase activity and TBARS caused by methionine might contribute to the neurophysiopathology observed in hypermethioninemic patients