98 research outputs found
Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols
We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT-OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT-OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling
Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon
In advanced studies directed toward the total synthesis of the kedarcidin chromophore, we have successfully achieved the late-stage installation of the nine-membered diyne ring in the presence of the highly functionalised ansamacrocyclic bridge
Solvent- and structure-dependent regioselectivity in the boron-mediated aldol reaction of 2-(1,3-dioxolan-2-yl)ethyl ethyl ketones
ChemInform Abstract: Silver(I) Oxide Mediated Highly Selective Monotosylation of Symmetrical Diols. Application to the Synthesis of Polysubstituted Cyclic Ethers.
ChemInform Abstract: Silver(I) Oxide Mediated Facile and Practical Sulfonylation of Alcohols.
ChemInform Abstract: Highly Selective Silver(I) Oxide Mediated Monoprotection of Symmetrical Diols.
Magnesium Bromide Mediated Highly Diastereoselective Heterogeneous Hydrogenation of Olefins.
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