Experience story: take care our children by promoting healthy behaviors

El siguiente relato de experiencia surge como iniciativa de la Secretaría de Salud Pública y Ambiente de la Facultad de Ciencias Médicas (FCM) de la Universidad Nacional de Córdoba (UNC), la cual impulsa una política destinada a potenciar el vínculo con la comunidad, abordando iniciativas y demandas que se reciben desde ámbitos escolares para brindar respuestas acordes a las necesidades, propiciando la extensión al medio. El objetivo principal fue divulgar y ofrecer conocimientos sobre principios, técnicas y habilidades de ayuda para propiciar conductas saludables para la vida en la población de niños en edad escolar bajo la modalidad de talleres participativos. Las experiencias se desarrollaron durante los años 2014 y 2015, en escuelas públicas y privadas de la ciudad de Córdoba, destacando siempre la importancia de reconocer factores protectores y conductas saludables, en un clima de respeto y solidaridad construido por todos.The following story of experience emerges as an initiative of the Ministry of Public Health and Environment of the Faculty of Medical Sciences (FCM) of the National University of Cordoba (UNC), which promotes a policy to maximize the link with the community, addressing initiatives and demands that are received from school settings to provide answers that meet the needs, promoting the extension to the medium. The main objective was to disseminate knowledge and provide principles, techniques and skills to help promote healthy behaviors for life in the population of school-age children in the form of participatory workshops. The experience developed during the years 2014 and 2015 in public and private schools in the city of Cordoba, always emphasizing the importance of recognizing protective factors and healthy behaviors, in a climate of respect and solidarity built by all.Informes de Proyectos - Programas de ExtensiónFacultad de Periodismo y Comunicación Socia

Therapeutic potential of fetal liver cells transplantation in hemophilia A mice

: Hemophilia A (HA) cell therapy approaches in pediatric individuals require suitable factor (F)VIII-producing cells for stable engraftment. Liver sinusoidal endothelial cells (LSEC) and hematopoietic stem cells (HSC) have been demonstrated to be suitable for the treatment of adult HA-mice. However, after transplantation in busulfan (BU)-conditioned newborn mice, adult LSEC/HSC cannot efficiently engraft, while murine fetal liver (FL) hemato/vascular cells from embryonic day 11-13 of gestation (E11-E13), strongly engraft the hematopoietic and endothelial compartments while also secreting FVIII. Our aim was to investigate the engraftment of FL cells in newborn HA mice for obtaining a suitable "proof of concept" for the development of a new HA treatment in neonates. Hence, we transplanted FLE11 or E13 cells and adult bone marrow (BM) cells into newborn HA mice with or without BU preconditioning. The engraftment levels and FVIII activity was assessed starting from 6 weeks after transplantation. FLE11-E13+BU-transplanted newborns reached up to 95% engraftment with stable FVIII activity levels observed for 16 months. FLE13 cells showed engraftment ability even in absence of BU preconditioning, while FLE11 cells did not. BM+BU transplanted newborn HA mice showed high levels of engraftment; nevertheless, in contrast to FL cells, BM cells cannot engraft HA newborns in non-conditioning regimen. Finally, none of the transplanted mice developed anti-FVIII antibodies. Overall, this study sheds some light on the therapeutic potential of healthy FL cells in the cure of HA neonatal/pediatric patients