Computer Modeling of the Joints for WGP Construction Systems

Poland is not situated in any seismic region of the earth, however there are still areas were underground mining is being conducted. In these areas, so-called 'paraseismic tremors', are very frequent phenomena. In the situation when a building examination is realized in order to define its safety, it is necessary to make a complete analysis, in which an influence of tremors should be included. To decide if a building is able to carry out any dynamic loads or not, it is necessary to compute its dynamic characteristics, i.e. natural frequencies. It is not possible using any standard techniques. After diagnosis a building in situ by an expert, computer techniques together with specialized software for dynamic, static, and strength analyses become a suitable tool. In this paper a special attention was paid to a typical twelve-store WGP (Wroclaw Great Plate) prefabricated building, concerning special type of joints. During dynamic actions these joints have a decisive influence on building's behavior. Paraseismic tremors are especially dangerous for these buildings and can be the reason of pre-failure states. It can be difficult and very expensive to prepare laboratory investigations of the part of a building or of a separate joint; therefore the computer modeling suitable to investigate behavior of such elements and whole buildings under different kinds of loads was used

An Algorithm of compromise structural Optimisation of Bar Structures

Authors' own research in applied unicriterial and multicriterial optimisation of bar structures, and also an analysis of accessible bibliography on structural synthesis allows to present herein an attempt to define a general algorithm for proceeding in formulation of a structural optimisation problem. A practical aspect of such an algorithm consists, in author's opinion, in enabling a designer a correct creation of a mathematical model of synthesis problems, independently of known mathematical methods employed to looking for an unconditional extremum of function of several variables. A proposed algorithm is not a ready-for-use tool for solving all the optimisation problems, but it constitutes an easy-to-expand theoretical basis. This basis should allow a designer to create a proper set of compromises on the way to construct a mathematical model of a specific optimisation problem. The algorithm, presented in the paper, is constructed as a sequence of the one-after-another problem questions, on which the designer answers: yes or no, and a set of selections from the knowledge base consisting of the elements of an optimisation problem components. The order of making questions adopted by the authors in the algorithm is subjective, however it is supported by their experience, both in applied optimisation and in designing of structures like trusses or frames

Computer Modeling of the Joints for WGP Construction Systems

Poland is not situated in any seismic region of the earth, however there are still areas were underground mining is being conducted. In these areas, so-called 'paraseismic tremors', are very frequent phenomena. In the situation when a building examination is realized in order to define its safety, it is necessary to make a complete analysis, in which an influence of tremors should be included. To decide if a building is able to carry out any dynamic loads or not, it is necessary to compute its dynamic characteristics, i.e. natural frequencies. It is not possible using any standard techniques. After diagnosis a building in situ by an expert, computer techniques together with specialized software for dynamic, static, and strength analyses become a suitable tool. In this paper a special attention was paid to a typical twelve-store WGP (Wroclaw Great Plate) prefabricated building, concerning special type of joints. During dynamic actions these joints have a decisive influence on building's behavior. Paraseismic tremors are especially dangerous for these buildings and can be the reason of pre-failure states. It can be difficult and very expensive to prepare laboratory investigations of the part of a building or of a separate joint; therefore the computer modeling suitable to investigate behavior of such elements and whole buildings under different kinds of loads was used

An Algorithm of compromise structural Optimisation of Bar Structures

Authors' own research in applied unicriterial and multicriterial optimisation of bar structures, and also an analysis of accessible bibliography on structural synthesis allows to present herein an attempt to define a general algorithm for proceeding in formulation of a structural optimisation problem. A practical aspect of such an algorithm consists, in author's opinion, in enabling a designer a correct creation of a mathematical model of synthesis problems, independently of known mathematical methods employed to looking for an unconditional extremum of function of several variables. A proposed algorithm is not a ready-for-use tool for solving all the optimisation problems, but it constitutes an easy-to-expand theoretical basis. This basis should allow a designer to create a proper set of compromises on the way to construct a mathematical model of a specific optimisation problem. The algorithm, presented in the paper, is constructed as a sequence of the one-after-another problem questions, on which the designer answers: yes or no, and a set of selections from the knowledge base consisting of the elements of an optimisation problem components. The order of making questions adopted by the authors in the algorithm is subjective, however it is supported by their experience, both in applied optimisation and in designing of structures like trusses or frames

Ontogenetic Serotoninergic Lesioning Alters Histaminergic Activity in Rats in Adulthood

The aim of this study was to determine histamine content in the brain and the effect of histamine receptor antagonists on behavior of adult rats lesioned as neonates with the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). At 3 days after birth Wistar rats were pretreated with desipramine (20 mg/kg ip) before bilateral icv administration of 5,7-DHT (37.5 μg base on each side) or saline-ascorbic (0.1%) vehicle (control). At 10 week levels of 5-HT and its metabolite 5-hydroxyindole acetic acid (5-HIAA) were determined in frontal cortex, striatum, and hippocampus by an HPLC/ED technique. In the hypothalamus, frontal cortex, hippocampus and medulla oblongata, the level of histamine was analyzed by an immunoenzymatic method. Behavioral observations (locomotion, exploratory-, oral-, and stereotyped activity) were performed, and effects of DA receptor agonists (SKF 38393, apomorphine) and histamine receptor antagonists S(+)chlorpheniramine (H1), cimetidine (H2), and thioperamide (H3) were determined. We confirmed that 5,7-DHT profoundly reduced contents of 5-HT and 5-HIAA in the brain in adulthood. Histamine content was also reduced in all examined brain regions. Moreover, in 5,7-DHT-lesioned rats the locomotor and oral activity responses to thioperamide were altered, and apomorphineinduced stereotype was intensified. From the above, we conclude that an intact central serotoninergic system modulates histamine H3 receptor antagonist effects on the dopaminergic neurons in rats

Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Trastuzumab resistance: Bringing tailored therapy to the clinic

SCOPUS: re.jinfo:eu-repo/semantics/publishe