Use of smokeless tobacco and risk of myocardial infarction and stroke: systematic review with meta-analysis

Objective To assess whether people who use smokeless tobacco products are at increased risk of myocardial infarction and stroke

Alcohol consumption and breast cancer risk

Boyle, Peter Boffetta, Paolo eng England 2010/01/20 06:00 Breast Cancer Res. 2009;11 Suppl 3:S3. doi: 10.1186/bcr2422. Epub 2009 Dec 18.International audienceno abstrac

Power Laws in Solar Flares: Self-Organized Criticality or Turbulence?

We study the time evolution of Solar Flares activity by looking at the statistics of quiescent times $\tau_{L}$ between successive bursts. The analysis of 20 years of data reveals a power law distribution with exponent $\alpha \simeq 2.4$ which is an indication of complex dynamics with long correlation times. The observed scaling behavior is in contradiction with the Self-Organized Criticality models of Solar Flares which predict Poisson-like statistics. Chaotic models, including the destabilization of the laminar phases and subsequent restabilization due to nonlinear dynamics, are able to reproduce the power law for the quiescent times. In the case of the more realistic Shell Model of MHD turbulence we are able to reproduce all the observed distributions.Comment: 4 pages, 4 postscript figures. Submitted to Physical Review Letter

A quick guide to cancer epidemiology

This short and essential book [1] is addressed essentially to medical and public health students, and to anyone interested in a summary up to date presentation of cancer epidemiology and prevention. It is subdivided into four major sections, that include principles of primary and secondary cancer prevention, the current global burden of neoplasms,..

Causation in the Presence of Weak Associations

none1siDespite their observational nature, epidemiologic studies have been used to make inductive inferences about the causes of human diseases. In this context, I mainly consider the term “cause” in its cognitive (explanatory) meaning, that is, by detecting causal factors and identifying mechanisms of diseases...openBoffetta, P.Boffetta, P

Mortality Patterns and Trends for Lung Cancer and Other Tobacco-Related Cancers in the Americas, 1955-1989

Mortality from cancers of the oral cavity and pharynx, oesphagus, larynx and lung between 1955 and 1989 has been analysed for USA, Canada and 14 countries in Latin America. Among males, Uruguay, Cuba, Argentina and Puerto Rico have the highest rates for all sites, and Peru, Ecuador, Dominican Republic, Mexico and Colombia have the lowest rates. Among females, Cuba, Colombia and Puerto Rico rank high for all sites, and Mexico, Paraguay, Ecuador and Peru rank low. For both sexes, lung cancer mortality rates from the US and Canada are high, whereas rates from other sites are intermediate. An increasing trend in lung cancer mortality over time is shown in all countries except Cuba (no changes), Argentina, Paraguay and Peru (decreasing trend). In Latin America, the tobacco-related lung cancer epidemic is in its early phase among males, and very early phase among female

Occupational and Environmental Exposures and Cancers in Developing Countries

Background: Over the past few decades, there has been a decline in cancers attributable to environmental and occupational carcinogens of asbestos, arsenic, and indoor and outdoor air pollution in high-income countries. For low- to middle-income countries (LMICs), however, these exposures are likely to increase as industrialization expands and populations grow. Objective: The aim of this study was to review the evidence on the cancer risks and burdens of selected environmental and occupational exposures in less-developed economies. Findings: A causal association has been established between asbestos exposure and mesotheliomaand lung cancer. For arsenic exposure, there is strong evidence of bladder, skin, lung, liver, and kidney cancer effects. Women are at the highest risk for lung cancer due to indoor air pollution exposure; however, the carcinogenic effect on the risk for cancer in children has not been studied in these countries. Cancer risks associated with ambient air pollution remain the least studied in LMICs, although reported exposures are higher than World Health Organization, European, and US standards. Although some associations between lung cancer and ambient air pollutants have been reported, studies in LMICs are weak or subject to exposure misclassification. For pulmonary cancers, tobacco smoking and respiratory diseases have a positive synergistic effect on cancer risks. Conclusions: A precise quantification of the burden of human cancer attributable to environmental and occupational exposures in LMICs is uncertain. Although the prevalence of carcinogenic exposures has been reported to be high in many such countries, the effects of the exposures have not been studied due to varying country-specific limitations, some of which include lack of resources and government support

Cancer in Low- and Medium-Income Countries

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Oats and bowel disease: a systematic literature review.

Whole-grain foods such as oats may protect against colorectal cancer and have benefits on inflammatory bowel disease and coeliac disease. The present study aimed to systematically review the literature describing intervention studies that investigated the effects of oats or oat bran on risk factors for bowel disease. A literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Thirty-eight articles describing twenty-nine studies met the inclusion criteria. Two studies carried out in participants with a history of colorectal adenomas found no effects of increased oat-bran intake on indirect risk makers for colorectal cancer. One of two interventions with oat bran in patients with ulcerative colitis showed small improvements in the patients' conditions. Most of the eleven studies carried out in adults with coeliac disease showed no negative effects of uncontaminated oat consumption. The fourteen studies carried out in volunteers with no history of bowel disease suggest that oats or oat bran can significantly increase stool weight and decrease constipation, but there is a lack of evidence to support a specific effect of oats on bowel function compared with other cereals. A long-term dietary intake of oats or oat bran could benefit inflammatory bowel disorders, but this remains to be proven. A protective effect on colorectal adenoma and cancer incidence has not yet been convincingly shown. The majority of patients with coeliac disease could consume up to 100 g/d of uncontaminated oats, which would increase the acceptability of, and adherence to, a gluten-free diet