MS-105: John L. Barry Civil War Letters

This collection contains 47 letters, 37 of which are written by John L. Barry during his time in the Civil War between 20 June 1861 and 7 June 1862. The letters are written to his family in Dunkirk, New York, addressing his mother, father, sister Ellen, and brother Robert. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1094/thumbnail.jp

MS-103: Jes Jerry Jessen World War I Letters

This collection contains 109 letters written by Jes Jerry Jessen addressed to his family in Spokane, WA, including his mother and father, his brothers George and Ralph, his sister Helen (“La La”) and his aunt Molly between June 6th, 1917 and June 22nd, 1919. These letters follow him through his training in Vancouver, Washington; Charlotte, North Carolina; France; and Germany, where his correspondence ends. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1092/thumbnail.jp

MS-104: World War II Letters from Carl G. Ohmer and Richard E. Ohmer

This collection contains 109 letters written by soldiers in World War II. 98 of these are letters are addressed to the Ohmer family in Girard, PA from their sons, Carl and Richard, as well as a friend of the family, Ray O’Connor. 11 of the letters are addressed to Georgia Hitchcock in New York, NY from John V. Starr, as well as one letter signed “Don,” with no other distinguishing factors of his identity. All letters include their original envelope. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1093/thumbnail.jp

MS-106: J.G. Morris & Morris-Hay Family Diaries

This collection contains 10 diaries ranging from 1827 to 1890, two of which are written by John Gottleib Morris and eight by M.A. Hay. These diaries contain church membership and donation records as well as Morris\u27 personal thoughts on the ministerial profession, and his duty to the church. He speaks on personal matters like his marriage and his children who have died. One diary also includes his note on the formation of the Lutherville Female College. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1095/thumbnail.jp

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

BACKGROUND: Tuberculosis is the world's leading infectious disease killer. We aimed to identify shorter, safer drug regimens for the treatment of tuberculosis. METHODS: We did a randomised controlled, open-label trial with a multi-arm, multi-stage design. The trial was done in seven sites in South Africa and Tanzania, including hospitals, health centres, and clinical trial centres. Patients with newly diagnosed, rifampicin-sensitive, previously untreated pulmonary tuberculosis were randomly assigned in a 1:1:1:1:2 ratio to receive (all orally) either 35 mg/kg rifampicin per day with 15–20 mg/kg ethambutol, 20 mg/kg rifampicin per day with 400 mg moxifloxacin, 20 mg/kg rifampicin per day with 300 mg SQ109, 10 mg/kg rifampicin per day with 300 mg SQ109, or a daily standard control regimen (10 mg/kg rifampicin, 5 mg/kg isoniazid, 25 mg/kg pyrazinamide, and 15–20 mg/kg ethambutol). Experimental treatments were given with oral 5 mg/kg isoniazid and 25 mg/kg pyrazinamide per day for 12 weeks, followed by 14 weeks of 5 mg/kg isoniazid and 10 mg/kg rifampicin per day. Because of the orange discoloration of body fluids with higher doses of rifampicin it was not possible to mask patients and clinicians to treatment allocation. The primary endpoint was time to culture conversion in liquid media within 12 weeks. Patients without evidence of rifampicin resistance on phenotypic test who took at least one dose of study treatment and had one positive culture on liquid or solid media before or within the first 2 weeks of treatment were included in the primary analysis (modified intention to treat). Time-to-event data were analysed using a Cox proportional-hazards regression model and adjusted for minimisation variables. The proportional hazard assumption was tested using Schoelfeld residuals, with threshold p<0·05 for non-proportionality. The trial is registered with ClinicalTrials.gov (NCT01785186). FINDINGS: Between May 7, 2013, and March 25, 2014, we enrolled and randomly assigned 365 patients to different treatment arms (63 to rifampicin 35 mg/kg, isoniazid, pyrazinamide, and ethambutol; 59 to rifampicin 10 mg/kg, isoniazid, pyrazinamide, SQ109; 57 to rifampicin 20 mg/kg, isoniazid, pyrazinamide, and SQ109; 63 to rifampicin 10 mg/kg, isoniazid, pyrazinamide, and moxifloxacin; and 123 to the control arm). Recruitment was stopped early in the arms containing SQ109 since prespecified efficacy thresholds were not met at the planned interim analysis. Time to stable culture conversion in liquid media was faster in the 35 mg/kg rifampicin group than in the control group (median 48 days vs 62 days, adjusted hazard ratio 1·78; 95% CI 1·22–2·58, p=0·003), but not in other experimental arms. There was no difference in any of the groups in time to culture conversion on solid media. 11 patients had treatment failure or recurrent disease during post-treatment follow-up: one in the 35 mg/kg rifampicin arm and none in the moxifloxacin arm. 45 (12%) of 365 patients reported grade 3–5 adverse events, with similar proportions in each arm. INTERPRETATION: A dose of 35 mg/kg rifampicin was safe, reduced the time to culture conversion in liquid media, and could be a promising component of future, shorter regimens. Our adaptive trial design was successfully implemented in a multi-centre, high tuberculosis burden setting, and could speed regimen development at reduced cost. FUNDING: The study was funded by the European and Developing Countries Clinical Trials partnership (EDCTP), the German Ministry for Education and Research (BmBF), and the Medical Research Council UK (MRC)

Glass Beads: Towards an Alternative Approach to the Science of Social Psychology

In Hermann Hesse's novel Magister Ludi, scholars in the future kingdom of Castalia play the Glass Bead Game. The players carry the patterns of relationships they find in works of art, music, literature, science, philosophy, mathematics, and history through patterns of transformations, finding joy in the counterpoint of expectations met, shattered, and met anew. The novel's own counterpoint lies in the thesis and antithesis of Castalia and the world, and the search of Joseph Knecht, Master of the Game, for the resolving theme. We find a similar dialectic in Pitirim Sorokin's theory of cultural mentalities. He contrasts the Sensate-worldly, materialistic, empirical--with the Ideational-spiritual, realistic, faithful. Each has its virtues and its viceso Sorokin does, however, offer us a respite from these partial mentalities, in the infrequent Idealistic. This variety blends faith and empiricism with reason, In my opinion, the Idealistic Mind finds its ultimate expression in Spinoza. Some time has past since then, and the pendulum has gone through its periods once or twice. It seems to me that psychology has suffered both from mechanism and scientific spiritualism, as well as from awkward combinations. Although the e~tremes have contributed to understanding and will continue to do so, they suffer in their effectiveness by splitting the scientist. This thesis is a small attempt at rejoining the objective and the subjective, the secular and the spiritual, the mind and the body, an attempt at mending at least one scientist. Whether or not it is successful is left to the judgement of the reader. If nothing elseg I hope it brings the possibility of this Idealistic alternative to the attention of a better mind than mine.Psycholog

Alienation and the Perception of Personality

Psycholog

Tuberculosis lymphadenitis, a diagnostic problem in areas of high prevalence of HIV and tuberculosis

No Abstrac

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania.

Kibong'oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania. A retrospective cohort study was performed among all patients treated at KNTH for pulmonary MDR-TB between November 2009 and September 2011. Sixty-one culture-positive MDR-TB patients initiated therapy, 60 (98%) with a prior history of TB treatment. Forty-one (67%) were male and 9 (14%) were HIV infected with a mean CD4 count of 424 (±106) cells/µl. The median time from specimen collection to MDR-TB diagnosis and from diagnosis to initiation of MDR-TB treatment was 138 days (IQR 101-159) and 131 days (IQR 32-233), respectively. Following treatment initiation four (7%) patients died (all HIV negative), 3 (5%) defaulted, and the remaining 54 (89%) completed the intensive phase. Most adverse drug reactions were mild to moderate and did not require discontinuation of treatment. Median time to culture conversion was 2 months (IQR 1-3) and did not vary by HIV status. In 28 isolates available for additional second-line drug susceptibility testing, fluoroquinolone, aminoglycoside and para-aminosalicylic acid resistance was rare yet ethionamide resistance was present in 9 (32%). The majority of MDR-TB patients from this cohort had survived a prolonged referral process, had multiple episodes of prior TB treatment, but did not have advanced AIDS and converted to culture negative early while completing an intensive inpatient regimen without serious adverse event. Further study is required to determine the clinical impact of second-line drug susceptibility testing and the feasibility of alternatives to prolonged hospitalization