89 research outputs found

    What! No Women

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    Illustration of man looking at pianohttps://scholarsjunction.msstate.edu/cht-sheet-music/11086/thumbnail.jp

    My Wonder Girl

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    Woman in front of curtains with butterfly on her shoulderhttps://scholarsjunction.msstate.edu/cht-sheet-music/6370/thumbnail.jp

    Mississippi Mammy

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    Illustration of woman sitting at cabin with flowers found cabinhttps://scholarsjunction.msstate.edu/cht-sheet-music/9259/thumbnail.jp

    First-Step Mutations for Adaptation at Elevated Temperature Increase Capsid Stability in a Virus

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    The relationship between mutation, protein stability and protein function plays a central role in molecular evolution. Mutations tend to be destabilizing, including those that would confer novel functions such as host-switching or antibiotic resistance. Elevated temperature may play an important role in preadapting a protein for such novel functions by selecting for stabilizing mutations. In this study, we test the stability change conferred by single mutations that arise in a G4-like bacteriophage adapting to elevated temperature. The vast majority of these mutations map to interfaces between viral coat proteins, suggesting they affect protein-protein interactions. We assess their effects by estimating thermodynamic stability using molecular dynamic simulations and measuring kinetic stability using experimental decay assays. The results indicate that most, though not all, of the observed mutations are stabilizing

    Bye bye baby.

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    Gift of Dr. Mary Jane Esplen.Featured by Vera Burt - Saxi Holtsworth and Orchestra [note]Piano vocal [instrumentation]Oh! dear oh! dear you're gonna be late [first line]Bye bye baby we'll meet bye and bye [first line of chorus]E flat major [key]Allegro moderato [tempo]Popular song [form/genre]Man, woman, bags, train ; Vera Burt - Saxi Holtsworth (photograph) [illustration]P & L Studios [engraver]Publisher's advertisement on front inside cover & back cover [note

    What! no women?

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    Gift of Dr. Mary Jane Esplen.Piano vocal ukulele [instrumentation]C major [key]Moderato [tempo]Popular song [form/genre]Man, piano, flower vase, lamp [illustration]Leff [engraver]Publisher's advertisement on back cover [note
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