Report of Commissioners Appointed to Settle with the Sureties of Benjamin D. Peck, Late Treasurer of Maine

Report focuses on the mishandling of bonds and tax revenue by the Treasurer of the State of Maine, Benjamin D. Peck.https://digicom.bpl.lib.me.us/books_pubs/1154/thumbnail.jp

Digital mammography, cancer screening: Factors important for image compression

The use of digital mammography for breast cancer screening poses several novel problems such as development of digital sensors, computer assisted diagnosis (CAD) methods for image noise suppression, enhancement, and pattern recognition, compression algorithms for image storage, transmission, and remote diagnosis. X-ray digital mammography using novel direct digital detection schemes or film digitizers results in large data sets and, therefore, image compression methods will play a significant role in the image processing and analysis by CAD techniques. In view of the extensive compression required, the relative merit of 'virtually lossless' versus lossy methods should be determined. A brief overview is presented here of the developments of digital sensors, CAD, and compression methods currently proposed and tested for mammography. The objective of the NCI/NASA Working Group on Digital Mammography is to stimulate the interest of the image processing and compression scientific community for this medical application and identify possible dual use technologies within the NASA centers

Some Design Considerations for Picture Archiving and Communication Systems

Design considerations for picture archiving and communication systems are reviewed with special emphasis on those issues that differ from conventional network architectures. Design equations for three layers of a picture network are developed and discussed in the context of preliminary estimates of the flow of digital images between a multiplicity of picture sources, picture archives and picture viewing stations. Discussions of differences from conventional networks focuses on the local nature of the net, the availability of a wide-band transmission media with low error rates, the relative costliness of network equipment capable of taking advantage of the wide-band transmission media and the preponderance of large blocks of image data in the network traffic. The locality of network traffic flows associated with the generation, storage and display of images is a characteristic of the radiology application that can probably be used to advantage

The spinorial geometry of supersymmetric heterotic string backgrounds

We determine the geometry of supersymmetric heterotic string backgrounds for which all parallel spinors with respect to the connection $\hat\nabla$ with torsion $H$, the NS$\otimes$NS three-form field strength, are Killing. We find that there are two classes of such backgrounds, the null and the timelike. The Killing spinors of the null backgrounds have stability subgroups K\ltimes\bR^8 in $Spin(9,1)$, for $K=Spin(7)$, SU(4), $Sp(2)$, $SU(2)\times SU(2)$ and $\{1\}$, and the Killing spinors of the timelike backgrounds have stability subgroups $G_2$, SU(3), SU(2) and $\{1\}$. The former admit a single null $\hat\nabla$-parallel vector field while the latter admit a timelike and two, three, five and nine spacelike $\hat\nabla$-parallel vector fields, respectively. The spacetime of the null backgrounds is a Lorentzian two-parameter family of Riemannian manifolds $B$ with skew-symmetric torsion. If the rotation of the null vector field vanishes, the holonomy of the connection with torsion of $B$ is contained in $K$. The spacetime of time-like backgrounds is a principal bundle $P$ with fibre a Lorentzian Lie group and base space a suitable Riemannian manifold with skew-symmetric torsion. The principal bundle is equipped with a connection $\lambda$ which determines the non-horizontal part of the spacetime metric and of $H$. The curvature of $\lambda$ takes values in an appropriate Lie algebra constructed from that of $K$. In addition $dH$ has only horizontal components and contains the Pontrjagin class of $P$. We have computed in all cases the Killing spinor bilinears, expressed the fluxes in terms of the geometry and determine the field equations that are implied by the Killing spinor equations.Comment: 73pp. v2: minor change

The spinorial geometry of supersymmetric backgrounds

We propose a new method to solve the Killing spinor equations of eleven-dimensional supergravity based on a description of spinors in terms of forms and on the Spin(1,10) gauge symmetry of the supercovariant derivative. We give the canonical form of Killing spinors for N=2 backgrounds provided that one of the spinors represents the orbit of Spin(1,10) with stability subgroup SU(5). We directly solve the Killing spinor equations of N=1 and some N=2, N=3 and N=4 backgrounds. In the N=2 case, we investigate backgrounds with SU(5) and SU(4) invariant Killing spinors and compute the associated spacetime forms. We find that N=2 backgrounds with SU(5) invariant Killing spinors admit a timelike Killing vector and that the space transverse to the orbits of this vector field is a Hermitian manifold with an SU(5)-structure. Furthermore, N=2 backgrounds with SU(4) invariant Killing spinors admit two Killing vectors, one timelike and one spacelike. The space transverse to the orbits of the former is an almost Hermitian manifold with an SU(4)-structure and the latter leaves the almost complex structure invariant. We explore the canonical form of Killing spinors for backgrounds with extended, N>2, supersymmetry. We investigate a class of N=3 and N=4 backgrounds with SU(4) invariant spinors. We find that in both cases the space transverse to a timelike vector field is a Hermitian manifold equipped with an SU(4)-structure and admits two holomorphic Killing vector fields. We also present an application to M-theory Calabi-Yau compactifications with fluxes to one-dimension.Comment: Latex, 54 pages, v2: clarifications made and references added. v3: minor changes. v4: minor change

Evolutionary conservation of ABA signaling for stomatal closure in ferns

ABA-driven stomatal regulation reportedly evolved after the divergence of ferns, during the early evolution of seed plants approximately 360 Mya. This hypothesis is based on the observation that the stomata of certain fern species are unresponsive to ABA, but exhibit passive hydraulic control. However, ABA-induced stomatal closure was detected in some mosses and lycophytes. Here, we observed that a number of ABA signaling and membrane transporter protein families diversified over the evolutionary history of land plants. The aquatic ferns Azolla filiculoides and Salvinia cucullata have representatives of 23 families of proteins orthologous to those of Arabidopsis thaliana and all other land plant species studied. Phylogenetic analysis of the key ABA signaling proteins indicates an evolutionarily conserved stomatal response to ABA. Moreover, comparative transcriptomic analysis has identified a suite of ABA responsive genes that differentially expressed in a terrestrial fern species, Polystichum proliferum. These genes encode proteins associated with ABA biosynthesis, transport, reception, transcription, signaling, and ion and sugar transport, which fit the general ABA signaling pathway constructed from Arabidopsis thaliana and Hordeum vulgare. The retention of these key ABA-responsive genes could have had a profound effect on the adaptation of ferns to dry conditions. Furthermore, stomatal assays have shown the primary evidence for ABA-induced closure of stomata in two terrestrial fern species P. proliferum and Nephrolepis exaltata. In summary, we report new molecular and physiological evidence for the presence of active stomatal control in ferns

Focusing of timelike worldsheets in a theory of strings

An analysis of the generalised Raychaudhuri equations for string world sheets is shown to lead to the notion of focusing of timelike worldsheets in the classical Nambu-Goto theory of strings. The conditions under which such effects can occur are obtained . Explicit solutions as well as the Cauchy initial value problem are discussed. The results closely resemble their counterparts in the theory of point particles which were obtained in the context of the analysis of spacetime singularities in General Relativity many years ago.Comment: 14 pages, RevTex, no figures, extended, to appear in Phys Rev

Aspects of spinorial geometry

We review some aspects of the spinorial geometry approach to the classification of supersymmetric solutions of supergravity theories. In particular, we explain how spinorial geometry can be used to express the Killing spinor equations in terms of a linear system for the fluxes and the geometry of spacetime. The solutions of this linear system express some of the fluxes in terms of the spacetime geometry and determine the conditions on the spacetime geometry imposed by supersymmetry. We also present some of the recent applications like the classification of maximally supersymmetric G-backgrounds in IIB, this includes the most general pp-wave solution preserving 1/2 supersymmetry, and the classification of N=31 backgrounds in ten and eleven dimensions.Comment: 17 pages. Invited review for Modern Physics Letters

Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling

Nucleosomes, the fundamental units of chromatin structure, are regulators and barriers to transcription, replication and repair. Post-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA processes. Histone H3(T118) is a site of phosphorylation [H3(T118ph)] and is implicated in regulation of transcription and DNA repair. We prepared H3(T118ph) by expressed protein ligation and determined its influence on nucleosome dynamics. We find H3(T118ph) reduces DNA–histone binding by 2 kcal/mol, increases nucleosome mobility by 28-fold and increases DNA accessibility near the dyad region by 6-fold. Moreover, H3(T118ph) increases the rate of hMSH2–hMSH6 nucleosome disassembly and enables nucleosome disassembly by the SWI/SNF chromatin remodeler. These studies suggest that H3(T118ph) directly enhances and may reprogram chromatin remodeling reactions