33 research outputs found

    Simulation of the Response of the Inner Hair Cell Stereocilia Bundle to an Acoustical Stimulus

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    Mammalian hearing relies on a cochlear hydrodynamic sensor embodied in the inner hair cell stereocilia bundle. It is presumed that acoustical stimuli induce a fluid shear-driven motion between the tectorial membrane and the reticular lamina to deflect the bundle. It is hypothesized that ion channels are opened by molecular gates that sense tension in tip-links, which connect adjacent stepped rows of stereocilia. Yet almost nothing is known about how the fluid and bundle interact. Here we show using our microfluidics model how each row of stereocilia and their associated tip links and gates move in response to an acoustical input that induces an orbital motion of the reticular lamina. The model confirms the crucial role of the positioning of the tectorial membrane in hearing, and explains how this membrane amplifies and synchronizes the timing of peak tension in the tip links. Both stereocilia rotation and length change are needed for synchronization of peak tip link tension. Stereocilia length change occurs in response to accelerations perpendicular to the oscillatory fluid shear flow. Simulations indicate that nanovortices form between rows to facilitate diffusion of ions into channels, showing how nature has devised a way to solve the diffusive mixing problem that persists in engineered microfluidic devices

    Experiencias de extensión en viviendas de escasos recursos en el sector rural de Tucumán

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    El objetivo del presente trabajo es presentar una experiencia realizada con alumnos y docentes de la Facultad de Arquitectura y Urbanismo de la Universidad Nacional de Tucumán, en relación con instalaciones sanitarias en viviendas rurales de la zona del Valle Calchaquí de la provincia de Tucumán, con incorporación de sistemas de calentamiento de agua solar.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES
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