Novel synthesis of 1,2-diaza-1,3-dienes with potential biological activity from cinnamic acids and diazonium salts of anilines

Cinnamic acids are an important class of phenolic compounds, which have many beneficial effects on human health but are also interesting synthetic intermediates thanks to the presence of several reactive sites. While studying the reactivity of cinnamic acids with diazonium salts from aromatic amines, an unexpected reactivity has been discovered, leading to the formation of 1,2-diaza-1,3-dienes instead of traditional diazo-coupling products. The new compounds have been fully characterized by mono and bidimensional NMR spectroscopy and mass spectrometry. Preliminary studies on the biological activity of the compounds have been carried out testing both their antibacterial and antitumor activity, leading to promising results

Author Correction: 3D measurement techniques for the hindfoot alignment angle from weight-bearing CT in a clinical population

Cone-beam CT (CBCT) scans now enable accurate measurements on foot skeletal structures with the advantage of observing these in 3D and in weight-bearing. Among the most common skeletal deformities, the varus/valgus of the hindfoot is the most complex to be represented, and a number of measure proposals have been published. This study aims to analyze and to compare these measurements from CBCT scans in a real clinical population with large such deformity. Ten patients with severe acquired adult fatfoot and indication for surgery underwent CBCT scans (Carestream, USA) while standing on that leg, before and after surgical correction. Corresponding 3D shape of each bone of the distal shank and hindfoot were defned (Materialise, Belgium). Six diferent techniques from the literature were used to calculate the varus/valgus deformity, i.e. the inclination of the hindfoot in the frontal plane of the shank. Standard clinical measurements by goniometers were taken for comparison. According to these techniques, and starting from a careful 3D reconstruction of the relevant foot skeletal structures, a large spectrum of measurements was found to represent the same hindfoot alignment angle. Most of them were very diferent from the traditional clinical measures. The assessment of the pre-operative valgus deformity and of the corresponding post-operative correction varied considerably. CBCT fnally allows 3D assessment of foot deformities in weight-bearing. Measurements from the diferent available techniques do not compare well, as they are based on very diferent approaches. It is recommended to be aware of the anatomical and functional concepts behind these techniques before clinical and surgical conclusions

Timing chirurgico nell’adenoma epatico sanguinante: case report

La diagnosi di adenoma epatico, la cui eziopatogenesi è spesso un rapporto con l’assunzione prolungata di estroprogestinici (il 90% degli adenomi si osserva in donne che hanno preso la ‘pillola’ per più di 5 anni), impone sempre una indicazione chirurgica resettiva. La ragione è data dalle caratteristiche peculiari della neoplasia, che sono la degenerazione maligna (4%) e l’elevato rischio di sanguinamento (30- 50%), intratumorale e/o intraaddominale, che aumenta in gravidanza e in puerperio. La regressione dopo sospensione della terapia ormonale, infatti, è poco frequente e non elimina il rischio di degenerazione e/o emorragia. La resezione epatica dovrebbe essere condotta in combinazione con appropriate procedure di embolizzazione endovascolare selettiva, considerato che la chirurgia in emergenza potrebbe imporre un sacrificio epatico maggiore, esponendo il paziente a morbilità e mortalità più elevate. I tempi di attesa dall’embolizzazione all’intervento elettivo non sono standardizzati e sono pertanto indicati dall’esperienza personale e soprattutto da un attento e seriato follow-up del paziente. Gli Autori riportano la propria esperienza nella strategia terapeutica e nel timing chirurgico di un caso di adenoma epatico sanguinante