Protocol de prevenció i control de l’escabiosi (sarna)

Escabiosi; Prevenció i control; TractamentEscabiosis; Prevención y control; TratamientoScabiosis; Prevention and control; TreatmentProtocol per als professionals d’epidemiologia i per als professionals assistencials que hagin de gestionar l’existència de casos i/o de brots epidèmics de sarna en qualsevol àmbit (familiar, escolar, centres sanitaris, institucions tancades, etc.)

Protocol de prevenció i control de l’escabiosi (sarna)

Escabiosi; Prevenció i control; TractamentEscabiosis; Prevención y control; TratamientoScabiosis; Prevention and control; TreatmentProtocol per als professionals d’epidemiologia i per als professionals assistencials que hagin de gestionar l’existència de casos i/o de brots epidèmics de sarna en qualsevol àmbit (familiar, escolar, centres sanitaris, institucions tancades, etc.)

International network of cancer genome projects

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of over 25,000 cancer genomes at the genomic, epigenomic, and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically-relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Immune networks : frequencies of antibody and idiotype producing B cell clones in various steady states

El copyright pertenece a The Rockefeller University PressThe network theory of the immune system can be reduced to the interactions between soluble and cell-bound idiotypes and combining sites, independently of the functional properties of the lymphocytes bearing those elements . After its original exposition, however, much attention has been drawn to the functionally opposing consequences of the activity mediated by distinct classes of lymphocytes. The "plusminus" general network interactions have thus been progressively substituted by "mini-networks" of suppressor and helper T cells, often disconnected from the overall regulatory influences maintaining steady states in a complete, and therefore circular, repertoire . It appeared important, therefore, to establish a primary, quantitative description of the immune elements in various steady states to provide the basis for a description of immune networks . This, on the other hand, would perhaps contribute to resolving the present problems of predicting pathways in network interactions and the consequences of specific manipulations . We have initiated these attempts by determining B cell precursor frequencies in quantitative assays , under conditions that limit only for the clonal precursor itself. This was done in a well-characterized system prototype of network regulation using monoclonal idiotypes and anti-idiotypesPeer reviewe

Protocol de prevenció i control de l’escabiosi (sarna)

Escabiosi; Prevenció i control; TractamentEscabiosis; Prevención y control; TratamientoScabiosis; Prevention and control; TreatmentProtocol per als professionals d’epidemiologia i per als professionals assistencials que hagin de gestionar l’existència de casos i/o de brots epidèmics de sarna en qualsevol àmbit (familiar, escolar, centres sanitaris, institucions tancades, etc.)