14,569 research outputs found
Review of the New Communities Program: Toward Effective Implementation of Neighborhood Plans
Evaluates the progress of the New Communities Program, an initiative to revitalize sixteen Chicago neighborhoods, and recommends extending the MacArthur Foundation's financial support through another five-year grant
The display of spatial information and visually guided behavior
The basic informational elements of spatial orientation are attitude and position within a coordinate system. The problem that faces aeronautical designers is that a pilot must deal with several coordinate systems, sometimes simultaneously. The display must depict unambiguously not only position and attitude, but also designate the relevant coordinate system. If this is not done accurately, spatial disorientation can occur. The different coordinate systems used in aeronautical tasks and the problems that occur in the display of spatial information are explained
Lens ER-stress response during cataract development in Mip-mutant mice
AbstractMajor intrinsic protein (MIP) is a functional water-channel (AQP0) that also plays a key role in establishing lens fiber cell architecture. Genetic variants of MIP have been associated with inherited and age-related forms of cataract; however, the underlying pathogenic mechanisms are unclear. Here we have used lens transcriptome profiling by microarray-hybridization and qPCR to identify pathogenic changes during cataract development in Mip-mutant (Lop/+) mice. In postnatal Lop/+ lenses (P7) 99 genes were up-regulated and 75 were down-regulated (>2-fold, p=<0.05) when compared with wild-type. A pathway analysis of up-regulated genes in the Lop/+ lens (P7) was consistent with endoplasmic reticulum (ER)-stress and activation of the unfolded protein response (UPR). The most up-regulated UPR genes (>4-fold) in the Lop/+ lens included Chac1>Ddit3>Atf3>Trib3>Xbp1 and the most down-regulated genes (>5-fold) included two anti-oxidant genes, Hspb1 and Hmox1. Lop/+ lenses were further characterized by abundant TUNEL-positive nuclei within central degenerating fiber cells, glutathione depletion, free-radical overproduction, and calpain hyper-activation. These data suggest that Lop/+ lenses undergo proteotoxic ER-stress induced cell-death resulting from prolonged activation of the Eif2ak3/Perk-Atf4-Ddit3-Chac1 branch of the UPR coupled with severe oxidative-stress
Multiscale models of colloidal dispersion of particles in nematic liquid crystals
We use homogenization theory to develop a multiscale model of colloidal dispersion of particles in nematic liquid crystals under weak-anchoring conditions. We validate the model by comparing it with simulations by using the Landau–de Gennes free energy and show that the agreement is excellent. We then use the multiscale model to study the effect that particle anisotropy has on the liquid crystal: spherically symmetric particles always reduce the effective elastic constant. Asymmetric particles introduce an effective alignment field that can increase the Fredericks threshold and decrease the switch-off time
Introducing a device to assist in the application of anti-embolism stockings
Using a device to help with the application and removal of anti-embolism stockings, often called thromboembolic deterrent stockings (TEDS), can potentially facilitate greater adherence to the use of stockings, and potentially reduce the risk of deep-vein thrombosis (DVT). This article describes a quality improvement project which used the Plan, Do, Study, Act (PDSA) cycle to facilitate the introduction of a device to aid in the application of thromboembolic deterrent stockings in an orthopaedic ward. The project findings showed that Neo-slip, a product designed to facilitate the use of compression stockings, can be effectively introduced into an orthopaedic ward, with positive feedback from both staff and patients
Economic analysis of the cost of inconsistencies in the implementation of ISDN network layer standards
Case studies depicting ISDN network layer interoperability and standards nonconformance were evaluated, and categorized by type. In each case study the root cause of the interoperability problem was identified, and validated with reference to the applicable ISDN standard. Corrective measures were proposed, and where implemented, the results of the correction were documented. Relative costs associated with the interoperability issue were identified, and recommendation\u27s outlining the best method for avoiding these inconsistencies going forward were presented
Germ-line and somatic EPHA2 coding variants in lens aging and cataract
Rare germ-line mutations in the coding regions of the human EPHA2 gene (EPHA2) have been associated with inherited forms of pediatric cataract, whereas, frequent, non-coding, single nucleotide variants (SNVs) have been associated with age-related cataract. Here we sought to determine if germ-line EPHA2 coding SNVs were associated with age-related cataract in a case-control DNA panel (> 50 years) and if somatic EPHA2 coding SNVs were associated with lens aging and/or cataract in a post-mortem lens DNA panel (> 48 years). Micro-fluidic PCR amplification followed by targeted amplicon (exon) next-generation (deep) sequencing of EPHA2 (17-exons) afforded high read-depth coverage (1000x) for > 82% of reads in the cataract case-control panel (161 cases, 64 controls) and > 70% of reads in the post-mortem lens panel (35 clear lens pairs, 22 cataract lens pairs). Novel and reference (known) missense SNVs in EPHA2 that were predicted in silico to be functionally damaging were found in both cases and controls from the age-related cataract panel at variant allele frequencies (VAFs) consistent with germ-line transmission (VAF > 20%). Similarly, both novel and reference missense SNVs in EPHA2 were found in the post-mortem lens panel at VAFs consistent with a somatic origin (VAF > 3%). The majority of SNVs found in the cataract case-control panel and post-mortem lens panel were transitions and many occurred at di-pyrimidine sites that are susceptible to ultraviolet (UV) radiation induced mutation. These data suggest that novel germ-line (blood) and somatic (lens) coding SNVs in EPHA2 that are predicted to be functionally deleterious occur in adults over 50 years of age. However, both types of EPHA2 coding variants were present at comparable levels in individuals with or without age-related cataract making simple genotype-phenotype correlations inconclusive
Torts -- Physicians and Surgeons -- Liability for Signing a Certificate of Insanity Without Proper Examination of the Alleged Lunatic
Banished from the Present: Musicians in Nazi Germany
This essay analyzes musical life in the Third Reich. More specifically, the focus will be on the Nazis’ regulation of music and the role that musicians themselves played in determining and enforcing cultural coordination. While some evidence extends into the war years (1939-1945), the bulk of the information presented here took place in the pre-war Nazi era (1933-1939). The purpose here is to show that those musicians who worked with and under the Nazis were affected in different ways and had varying levels of agency within the National Socialist system. Some have been branded collaborators, others victims, and this paper will question this binary system of classification. Following a trend of historical revisionism in this field, this paper takes into account that the question of culpability is now less certain than ever
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