Towards Business-to-IT Alignment in the Cloud

Cloud computing offers a great opportunity for business process (BP) flexibility, adaptability and reduced costs. This leads to realising the notion of business process as a service (BPaaS), i.e., BPs offered on-demand in the cloud. This paper introduces a novel architecture focusing on BPaaS design that includes the integration of existing state-of-the-art components as well as new ones which take the form of a business and a syntactic matchmaker. The end result is an environment enabling to transform domain-specific BPs into executable workflows which can then be made deployable in the cloud so as to become real BPaaSes

Drug dosing during pregnancy—opportunities for physiologically based pharmacokinetic models

Drugs can have harmful effects on the embryo or the fetus at any point during pregnancy. Not all the damaging effects of intrauterine exposure to drugs are obvious at birth, some may only manifest later in life. Thus, drugs should be prescribed in pregnancy only if the expected benefit to the mother is thought to be greater than the risk to the fetus. Dosing of drugs during pregnancy is often empirically determined and based upon evidence from studies of non-pregnant subjects, which may lead to suboptimal dosing, particularly during the third trimester. This review collates examples of drugs with known recommendations for dose adjustment during pregnancy, in addition to providing an example of the potential use of PBPK models in dose adjustment recommendation during pregnancy within the context of drug-drug interactions. For many drugs, such as antidepressants and antiretroviral drugs, dose adjustment has been recommended based on pharmacokinetic studies demonstrating a reduction in drug concentrations. However, there is relatively limited (and sometimes inconsistent) information regarding the clinical impact of these pharmacokinetic changes during pregnancy and the effect of subsequent dose adjustments. Examples of using pregnancy PBPK models to predict feto-maternal drug exposures and their applications to facilitate and guide dose assessment throughout gestation are discussed

Etude thermodynamique et élaboration de dépôts métalliques (W-N-C, Ti-N-C) par PEALD (Plasma Enhanced Atomic Layer Deposition) pour la réalisation d'électrodes de capacités Métal/Isolant/Métal dans les circuits intégrés.

MIM (Metal Insulator Metal) capacitors are widely integrated for RF and analog applications. The 3D architecture allows a capacitance density gain but require high conformality deposition technique to get conformal layers and high performance. PEALD method was used for the electrode and dielectric thin films deposition. Electrodes must exhibit a low resistivity, present a high work function and exhibit a good chemical compatibility with the dielectric material. To address these issues, Ti-N-C and W-N-C films have been investigated and deposited from organometallic precursors TDMAT et BTBMW. Chemical and electrical properties of the elaborated films and their integration as electrode in MIM capacitors are investigatedLes capacités MIM (Métal/Isolant/Métal), au coeur de cette étude, sont des composants intégrés entre les niveaux d'interconnections. Le développement de nouvelle architecture en trois dimensions impose de déposer les films ultraminces constituant la capacité MIM de manière très conforme. Ce qui conduit à utiliser un nouveau procédé de dépôt : la méthode ALD assistée par plasma ou PEALD. De plus l'augmentation des performances électriques des MIM passe par une maîtrise des propriétés des électrodes et des interfaces créées entre le diélectrique et les électrodes métalliques. Les matériaux développés dans cette étude sont Ti- N-C and W-N- C, déposés par PEALD à partir de précurseurs organométalliques TDMAT et BTBMW. Une étude sur les propriétés physico-chimiques et électriques des films est effectuée ainsi que l'intégration de ces films dans les capacités MIM

Microstructural changes induced by the pyrolysis step on epitaxial La2Zr2O7 thin films grown by Metalorganic Decomposition

International audienceno abstrac

Low-Temperature low-resistivity PEALD TiN using TDMAT under hydrogen redecing ambient

International audienc