How to use real-time location tracking without becoming ‘big brother’

For years, industries have been geolocating their workers and products, but COVID-19 has catapulted it into a new era, writes Fabio Bellon

Ultra Luminous X-ray Sources: a deeper insight into their spectral evolution

We select a sample of nearby Ultraluminous X-ray sources with long XMM-Newton observations and analyse all the available XMM-Newton data using both X-ray spectral fitting techniques and hardness-intensity diagrams. The sample includes IC 342 X-1, NGC 5204 X-1, NGC 5408 X-1, Holmberg IX X-1, Holmberg II X-1, NGC 1313 X-1, NGC 1313 X-2 and NGC 253 X-1. We found that, although a common reference model can be used to describe the X-ray spectra, the sources show different spectral evolutions, phenomenologically described in terms of variations in the properties of a soft component and a high energy tail. Variations at low energies are accounted for (mostly) by changes in the normalization of the soft component and/or in the column density to the source, while variations in the high energy tail by changes in the parameters of an optically thick corona. This spectral variability is rather well characterized on a colour-colour and hardness-intensity diagram in terms of suitably defined hardness ratios. We suggest the existence of a variability pattern on the hardness-intensity diagram and we interpret it in terms of the switch between a near-Eddington and a super-Eddington accretion regime. The transition between the two regimes seems to be driven mostly by changes in the contribution of the soft component, which can be explained in terms of the increasing importance of wind emission. The analysis is complemented by an investigation of the short-term time variability of all the sources. In general, no clear correlation between the spectral and temporal properties is found.Comment: 15 pages, 7 figures, 5 tables. Accepted for publication in MNRA

Measurement of the neutron capture cross-section of 236U

Proposal: Measurement of the neutron capture cross-section of 236UPreprin

Novel voltage compressor circuit by transmission lines

0034-674

Neutron beam imaging with micromegas detectors in combination with neutron time-of-flight at the n_tof facility at CERN

A bulk micromegas detector with the anode segmented in 2 orthogonal directions and equipped with a neutron/charged particle converter is employed at the neutron time-of-light (nTOF) facility at CERN to determine the incident neutron beam profile and beam interception factor as a function of the neutron energy determined by the time of flight. Discrepancies between experimental results and simulations in the values of the beam interception factor range up to 12 % and are to be ascribed to a defect in the mesh of the bulk. Nevertheless the detector proved to be really useful for checking the alignment of the neutron beam optics of the facility. Measurements with a new pixelized bulk detector for the determination of the beam interception factor are forseen before the end of 2012Postprint (published version

SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients

The expression rate of SARS-CoV-2 entry genes, angiotensin-converting enzyme 2 (ACE2), the main viral receptor and the proteases, furin and transmembrane serine protease 2 (TMPRSS2) in cystic fibrosis (CF) individuals is poorly known. Hence, we examined their levels in upper respiratory samples of CF patients (n = 46) and healthy controls (n = 45). Moreover, we sought to understand the interplay of type I interferon (IFN-I) with ACE2, furin and TMPRSS2 by evaluating their gene expression with respect to ISG15, a well-known marker of IFN activation, in upper respiratory samples and after ex vivo IFNβ exposure. Lower ACE2 levels and trends toward the reduction of furin and TMPRSS2 were found in CF patients compared with the healthy controls; decreased ACE2 amounts were also detected in CF individuals with pancreatic insufficiency and in those receiving inhaled antibiotics. Moreover, there was a strong positive correlation between ISG15 and ACE2 levels. However, after ex vivo IFNβ stimulation of nasopharyngeal cells, the truncated isoform (dACE2), recently demonstrated as the IFN stimulated one with respect to the full-length isoform (flACE2), slightly augmented in cells from CF patients whereas in those from healthy donors, dACE2 levels showed variable levels of upregulation. An altered expression of SARS-COV-2 entry genes and a poor responsiveness of dACE2 to IFN-I stimulation might be crucial in the diffusion of SARS-CoV-2 infection in CF

MICRObiota on BILIOpancreatic malignant diseases [MICROBILIO]: A systematic review

Introduction: The increase in the incidence of pancreatic and biliary cancers has attracted the search for methods of early detection of diseases and biomarkers. The authors propose to analyze new findings on the association between microbiota and Pancreatic Ductal Adenocarcinoma (PDAC) or Cholangiocarcinoma (CCA). Methods: This systematic review was carried out according to the items of Preferred Reports for Systematic Reviews and Protocol Meta-Analysis (PRISMA-P). This study was registered by the Prospective Register of Systematic Reviews (PROSPERO), identification code CRD42020192748 before the review was carried out. Articles were selected from the PUBMED, EMBASE, and Cochrane databases. Results: Most studies (86.67%) used 16s rRNA as a sequencing method. The main comorbidities found were diabetes mellitus, systemic arterial hypertension, and dyslipidemia. Many studies were limited by the small number of participants, but the biases were mostly low. There was very little concordance about the composition of the microbiome of different sites, for both case and control groups when compared to other studies' results. Bile sample analysis was the one with a greater agreement between studies, as three out of four studies found Escherichia in cases of CCA. Conclusion: There was great disagreement in the characterization of both the microbiota of cases and control groups. Studies are still scarce, making it difficult to adequately assess the data in this regard. It was not possible to specify any marker or to associate any genus of microbiota bacteria with PDAC or CCA

Protective effect of EDTA preadministration on renal ischemia

BACKGROUND: Chelation therapy with sodium edetate (EDTA) improved renal function and slowed the progression of renal insufficiency in patients subjected to lead intoxication. This study was performed to identify the underlying mechanism of the ability of EDTA treatment to protect kidneys from damage. METHODS: The effects of EDTA administration were studied in a rat model of acute renal failure induced by 60 minutes ischemia followed or not by 60 minutes reperfusion. Renal ischemic damage was evaluated by histological studies and by functional studies, namely serum creatinine and blood urea nitrogen levels. Treatment with EDTA was performed 30 minutes before the induction of ischemia. Polymorphonuclear cell (PMN) adhesion capability, plasmatic nitric oxide (NO) levels and endothelial NO synthase (eNOS) renal expression were studied as well as the EDTA protection from the TNFα-induced vascular leakage in the kidneys. Data was compared by two-way analysis of variance followed by a post hoc test. RESULTS: EDTA administration resulted in the preservation of both functional and histological parameters of rat kidneys. PMN obtained from peripheral blood of EDTA-treated ischemized rats, displayed a significant reduction in the expression of the adhesion molecule Mac-1 with respect to controls. NO was significantly increased by EDTA administration and eNOS expression was higher and more diffuse in kidneys of rats treated with EDTA than in the controls. Finally, EDTA administration was able to prevent in vivo the TNFα-induced vascular leakage in the kidneys. CONCLUSION: This data provides evidence that EDTA treatment is able to protect rat kidneys from ischemic damage possibly through the stimulation of NO production