13,258 research outputs found

    Patterns of Sponge Abundance Across a Gradient of Habitat Quality in the Wakatobi Marine National Park, Indonesia

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    Sponges are important components of reef communities worldwide, fulfilling a number of important functional roles. Habitat degradation caused by the loss of hard corals has the potential to cause increases in sponge abundance and percentage cover as they gain access to resources such as space and food. In this study we compared sponge densities and percentage cover at sites with varying hard coral cover in the Wakatobi Marine National Park, Indonesia (WMNP). We found significant differences in sponge densities at the study sites but no significant difference in sponge densities on different surface angles. Unexpectedly, we also found a weak positive correlation between coral cover and sponge density. This indicates that spatial competition is unlikely to be the most important factor determining sponge abundance in the WMNP. In contrast to sponge density data, we found that sponge percentage cover and hard coral cover were weakly negatively correlated, but found no significant difference in sponge percentage cover between the study sites. Finally, multivariate analysis of the benthic communities at the study sites indicated that while sites with higher coral cover were characterised by coral (proportionally), lower coral cover sites were characterised by algae and sponges. This suggests that although there was no significant difference in sponge percentage cover between the study sites conditions that led to the loss of hard coral at lower quality sites mean that these sites are characterised by sponges and algae rather than by any other groups of benthic organisms

    Two-Stage LASSO ADMM Signal Detection Algorithm For Large Scale MIMO

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    This paper explores the benefit of using some of the machine learning techniques and Big data optimization tools in approximating maximum likelihood (ML) detection of Large Scale MIMO systems. First, large scale MIMO detection problem is formulated as a LASSO (Least Absolute Shrinkage and Selection Operator) optimization problem. Then, Alternating Direction Method of Multipliers (ADMM) is considered in solving this problem. The choice of ADMM is motivated by its ability of solving convex optimization problems by breaking them into smaller sub-problems, each of which are then easier to handle. Further improvement is obtained using two stages of LASSO with interference cancellation from the first stage. The proposed algorithm is investigated at various modulation techniques with different number of antennas. It is also compared with widely used algorithms in this field. Simulation results demonstrate the efficacy of the proposed algorithm for both uncoded and coded cases.Comment: 5 pages, 4 figure

    Endangered Toponymy along the Nubian Nile

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    Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62

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    ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses. However, in addition to their pathogenic roles in allergic and autoimmune diseases, mast cells are important in fighting infection, wound healing, and resolving inflammation, reflecting that mast cells exhibit a phenotypic and functional plasticity. We have therefore characterised the differential functional responses to antigen (via Fc휀RI) and LPS and their modulation by ES-62 of the mature peritoneal-derived mast cells (PDMC; serosal) and those of the connective tissue-like mast cells (CTMC) and themucosal-likemast cells derived from bone marrow progenitors (BMMC) as a first step to produce disease tissue-targeted therapeutics based on ES-62 action. All three mast cell populations were rendered hyporesponsive by ES-62 and whilst the mechanisms underlying such desensitisation have not been fully delineated, they reflect a downregulation of calcium and PKC훼 signalling. ES-62 also downregulatedMyD88 and PKC훿 in mucosal-type BMMC but not PDMC, the additional signals targeted in mucosal-type BMMC likely reflecting that these cells respond to antigen and LPS by degranulation and cytokine secretion whereas PDMC predominantly respond in a degranulationbased manner

    Comparative effectiveness of diversion of cerebrospinal fluid for children with severe traumatic brain injury

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    Importance: Diversion of cerebrospinal fluid (CSF) has been used for decades as a treatment for children with severe traumatic brain injury (TBI) and is recommended by evidenced-based guidelines. However, these recommendations are based on limited studies. Objective: To determine whether CSF diversion is associated with improved Glasgow Outcome Score-Extended for Pediatrics (GOS-EP) and decreased intracranial pressure (ICP) in children with severe TBI. Design, Setting, and Participants: This observational comparative effectiveness study was performed at 51 clinical centers that routinely care for children with severe TBI in 8 countries (US, United Kingdom, Spain, the Netherlands, Australia, New Zealand, South Africa, and India) from February 2014 to September 2017, with follow-up at 6 months after injury (final follow-up, October 22, 2021). Children with severe TBI were included if they had Glasgow Coma Scale (GCS) scores of 8 or lower, had intracranial pressure (ICP) monitor placed on-site, and were aged younger than 18 years. Children were excluded if they were pregnant or an ICP monitor was not placed at the study site. Consecutive children were screened and enrolled, data regarding treatments were collected, and at discharge, consent was obtained for outcomes testing. Propensity matching for pretreatment characteristics was performed to develop matched pairs for primary analysis. Data analyses were completed on April 18, 2022. Exposures: Clinical care followed local standards, including the use of CSF diversion (or not), with patients stratified at the time of ICP monitor placement (CSF group vs no CSF group). Main Outcomes and Measures: The primary outcome was GOS-EP at 6 months, while ICP was considered as a secondary outcome. CSF vs no CSF was treated as an intention-to-treat analysis, and a sensitivity analysis was performed for children who received delayed CSF diversion. Results: A total of 1000 children with TBI were enrolled, including 314 who received CSF diversion (mean [SD] age, 7.18 [5.45] years; 208 [66.2%] boys) and 686 who did not (mean [SD] age, 7.79 [5.33] years; 437 [63.7%] boys). The propensity-matched analysis included 98 pairs. In propensity score-matched analyses, there was no difference between groups in GOS-EP (median [IQR] difference, 0 [-3 to 1]; P = .08), but there was a decrease in overall ICP in the CSF group (mean [SD] difference, 3.97 [0.12] mm Hg; P \u3c .001). Conclusions and Relevance: In this comparative effectiveness study, CSF diversion was not associated with improved outcome at 6 months after TBI, but a decrease in ICP was observed. Given the higher quality of evidence generated by this study, current evidence-based guidelines related to CSF diversion should be reconsidered

    Modelling the student journey using customer journey mapping: moments of truth in the educational journey

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    Nations widely acknowledge the potential of education in shaping both the individual and society. There is a constant effort to develop a model to understand students’ journeys which includes understanding what they go through during the whole process of education. This study creates a basic model to understand students’ experiences before, during and after study periods of formal education at the University of Technology and Applied Sciences, Muscat. An interactive discussion in the form of a semi-structured interview with final-year students was conducted to collect in-depth information related to the six phases of a student’s journey. It concludes with an examination of six moments of truth, each of which is defined and explained using various touchpoints. The sample was students in training who had completed all courses before receiving their Bachelor’s degree (N=156) across the Business Studies, Engineering and Applied Sciences departments, including on-the-job training students pursuing. The semi-structured interview method was used as the method of data collection. The objective of this paper was to assess the application of the concept of customer journey mapping to design a methodology to map students’ journeys from their points of view and develop a system that delivers a better experience for students. The user-centred design (UCD) was used for summarising the outcome of students’ responses. The analysis is an effort to highlight the touchpoints which need to be taken improved on and also the touchpoints which are well appreciated by the students
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