Efficient Feature Selection and Classification of Protein Sequence Data in Bioinformatics

Bioinformatics has been an emerging area of research for the last three decades. The ultimate aims of bioinformatics were to store and manage the biological data, and develop and analyze computational tools to enhance their understanding. The size of data accumulated under various sequencing projects is increasing exponentially, which presents difficulties for the experimental methods. To reduce the gap between newly sequenced protein and proteins with known functions, many computational techniques involving classification and clustering algorithms were proposed in the past. The classification of protein sequences into existing superfamilies is helpful in predicting the structure and function of large amount of newly discovered proteins. The existing classification results are unsatisfactory due to a huge size of features obtained through various feature encoding methods. In this work, a statistical metric-based feature selection technique has been proposed in order to reduce the size of the extracted feature vector. The proposed method of protein classification shows significant improvement in terms of performance measure metrics: accuracy, sensitivity, specificity, recall, F-measure, and so forth

Pushing Boundaries: Exploring Zero Shot Object Classification with Large Multimodal Models

$$The synergy of language and vision models has given rise to Large Language and Vision Assistant models (LLVAs), designed to engage users in rich conversational experiences intertwined with image-based queries. These comprehensive multimodal models seamlessly integrate vision encoders with Large Language Models (LLMs), expanding their applications in general-purpose language and visual comprehension. The advent of Large Multimodal Models (LMMs) heralds a new era in Artificial Intelligence (AI) assistance, extending the horizons of AI utilization. This paper takes a unique perspective on LMMs, exploring their efficacy in performing image classification tasks using tailored prompts designed for specific datasets. We also investigate the LLVAs zero-shot learning capabilities. Our study includes a benchmarking analysis across four diverse datasets: MNIST, Cats Vs. Dogs, Hymnoptera (Ants Vs. Bees), and an unconventional dataset comprising Pox Vs. Non-Pox skin images. The results of our experiments demonstrate the model's remarkable performance, achieving classification accuracies of 85\%, 100\%, 77\%, and 79\% for the respective datasets without any fine-tuning. To bolster our analysis, we assess the model's performance post fine-tuning for specific tasks. In one instance, fine-tuning is conducted over a dataset comprising images of faces of children with and without autism. Prior to fine-tuning, the model demonstrated a test accuracy of 55\%, which significantly improved to 83\% post fine-tuning. These results, coupled with our prior findings, underscore the transformative potential of LLVAs and their versatile applications in real-world scenarios.Comment: 5 pages,6 figures, 4 tables, Accepted on The International Symposium on Foundation and Large Language Models (FLLM2023

Can ChatGPT be Your Personal Medical Assistant?

The advanced large language model (LLM) ChatGPT has shown its potential in different domains and remains unbeaten due to its characteristics compared to other LLMs. This study aims to evaluate the potential of using a fine-tuned ChatGPT model as a personal medical assistant in the Arabic language. To do so, this study uses publicly available online questions and answering datasets in Arabic language. There are almost 430K questions and answers for 20 disease-specific categories. GPT-3.5-turbo model was fine-tuned with a portion of this dataset. The performance of this fine-tuned model was evaluated through automated and human evaluation. The automated evaluations include perplexity, coherence, similarity, and token count. Native Arabic speakers with medical knowledge evaluated the generated text by calculating relevance, accuracy, precision, logic, and originality. The overall result shows that ChatGPT has a bright future in medical assistance.Comment: 5 pages, 7 figures, two tables, Accepted on The International Symposium on Foundation and Large Language Models (FLLM2023

Portfolio Selection Problem Using CVaR Risk Measures Equipped with DEA, PSO, and ICA Algorithms

Investors always pay attention to the two factors of return and risk in portfolio optimization. There are different metrics for the calculation of the risk factor, among which the most important one is the Conditional Value at Risk (CVaR). On the other hand, Data Envelopment Analysis (DEA) can be used to form the optimal portfolio and evaluate its efficiency. In these models, the optimal portfolio is created by stocks or companies with high efficiency. Since the search space is vast in actual markets and there are limitations such as the number of assets and their weight, the optimization problem becomes difficult. Evolutionary algorithms are a powerful tool to deal with these difficulties. The automotive industry in Iran involves international automotive manufacturers. Hence, it is essential to investigate the market related to this industry and invest in it. Therefore, in this study we examined this market based on the price index of the automotive group, then optimized a portfolio of automotive companies using two methods. In the first method, the CVaR measurement was modeled by means of DEA, then Particle Swarm Optimization (PSO) and the Imperial Competitive Algorithm (ICA) were used to solve the proposed model. In the second method, PSO and ICA were applied to solve the CVaR model, and the efficiency of the portfolios of the automotive companies was analyzed. Then, these methods were compared with the classic Mean-CVaR model. The results showed that the automotive price index was skewed to the right, and there was a possibility of an increase in return. Most companies showed favorable efficiency. This was displayed the return of the portfolio produced using the DEA-Mean-CVaR model increased because the investment proposal was basedon the stock with the highest expected return and was effective at three risk levels. It was found that when solving the Mean-CVaR model with evolutionary algorithms, the risk decreased. The efficient boundary of the PSO algorithm was higher than that of the ICA algorithm, and it displayed more efficient portfolios.Therefore, this algorithm was more successful in optimizing the portfolio

A Magnetite Composite of Molecularly Imprinted Polymer and Reduced Graphene Oxide for Sensitive and Selective Electrochemical Detection of Catechol in Water and Milk Samples: An Artificial Neural Network (ANN) Application

In the present study, a stable and more selective electrochemical sensor for catechol (CC) detection at magnetic molecularly imprinted polymer modified with green reduced graphene oxide modified glassy carbon electrode (MIP/rGO@Fe3O4/GCE). Two steps have been applied to achieve the imprinting process: (1) adsorption of CC on the surface of the polypyrrole (Ppyr) during the polymerization of pyrrole and (2) the green extraction of the template (CC) from the mass produced. Hence, the present paper doesn't present the first use of MIP technology for CC identification but, it presents a new extraction process. The MIP/rGO@Fe3O4/GCE was characterized by voltammetry techniques and exhibited a wide linear range from1 50 mu M of CC while the detection limits were estimated to be around 4.18 nM CC and limit of quantification in the range of 12.69 nM CC. Furthermore, the prepared MIP-based sensor provided outstanding electroanalytical performances including high selectivity, stability, repeatability, and reproducibility. For the accurate estimation of CC concentrations, an artificial neural network (ANN) was developed based on the findings of the study. The MIP/rGO@Fe3O4/GCE exhibits excellent stability with a very important selectivity and sensitivity. The analytical testing of the modified electrode has been analyzed in water and commercial milk samples and provided adequate recoveries. (c) 2023 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited

Optimization of Interval Type-2 Fuzzy Logic System Using Grasshopper Optimization Algorithm

The estimation of the fuzzy membership function parameters for interval type 2 fuzzy logic system (IT2-FLS) is a challenging task in the presence of uncertainty and imprecision. Grasshopper optimization algorithm (GOA) is a fresh population based meta-heuristic algorithm that mimics the swarming behavior of grasshoppers in nature, which has good convergence ability towards optima. The main objective of this paper is to apply GOA to estimate the optimal parameters of the Gaussian membership function in an IT2-FLS. The antecedent part parameters (Gaussian membership function parameters) are encoded as a population of artificial swarm of grasshoppers and optimized using its algorithm. Tuning of the consequent part parameters are accomplished using extreme learning machine. The optimized IT2-FLS (GOAIT2FELM) obtained the optimal premise parameters based on tuned consequent part parameters and is then applied on the Australian national electricity market data for the forecasting of electricity loads and prices. The forecasting performance of the proposed model is compared with other population-based optimized IT2-FLS including genetic algorithm and artificial bee colony optimization algorithm. Analysis of the performance, on the same data-sets, reveals that the proposed GOAIT2FELM could be a better approach for improving the accuracy of the IT2-FLS as compared to other variants of the optimized IT2-FLS

Revisited Carmichael’s Reduced Totient Function

The modified Totient function of Carmichael λ(.) is revisited, where important properties have been highlighted. Particularly, an iterative scheme is given for calculating the λ(.) function. A comparison between the Euler φ and the reduced totient λ(.) functions aiming to quantify the reduction between is given