Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Using History to Teach Contemporary Psychology

Gaining a perspective on the evolution of psychological concepts can show students the power of theory and societal perspective in shaping scientific ideas across time. In this article, the author uses two constructs, the broad concept of intelligence and the narrow concept of combat stress reaction, to illustrate how psychologists have grappled with these ideas over the past century. These examples can provide a model for using the history of psychology to explain how ideas have taken their shape. These illustrations also show the difficulty in developing ideas that are scientifically useful and that periodic changes in the conceptualization of ideas are a normal feature of a dynamic discipline. © 2011, Society for the Teaching of Psychology. All rights reserved

TEaching Measurement Through Historical Sources

This article provides an example of the use of historical issues associated with intelligence testing to teach about the nature of measurement in psychology and includes pedagogical questions for the classroom. Students learning about research may assume that the ways psychologists measure constructs are permanent and immutable. However, using intelligence as the focus, this article shows how its measurement evolved, reflecting contemporaneous theories and assumptions. The initial sensory and psychophysical measurements designed by Cattell (1890) to measure mental ability were logically defensible in his era and gained temporary acceptance by many psychologists. Currently, standardized tests reflect the biases of later psychologists. The article highlights reasons for such changes. © 2010 American Psychological Association

STP at 75: Development of Teaching Resources

© The Author(s) 2020. The Society for the Teaching of Psychology (STP) is celebrating its 75th anniversary as a division of the American Psychological Association. During its history, it has served as a repository of materials for the teaching of psychology. This article highlights the discussion among longtime STP members and officers who played key roles in the evolution of the repository and provides some suggestions as to its future

Early Tests of Piagetian Theory Through World War II

Psychologists recognized the importance of Jean Piaget\u27s theory from its inception. Within a year of the appearance of his first book translated into English, The Language and Thought of the Child(J. Piaget, 1926), it had been reviewed and welcomed; shortly thereafter, psychologists began testing the tenets of the theory empirically. The author traces the empirical testing of his theory in the 2 decades following publication of his initial book. A review of the published literature through the World War II era reveals that the research resulted in consistent failure to support the theoretical mechanisms that Piaget proposed. Nonetheless, the theory ultimately gained traction to become the bedrock of developmental psychology. Reasons for its persistence may include a possible lack of awareness by psychologists about the lack of empirical support, its breadth and complexity, and a lack of a viable alternate theory. As a result, the theory still exerts influence in psychology even though its dominance has diminished

APA style simplified : writing in psychology, education, nursing and sociology

x, 202 p : il.; 21 c

Apa style simplified : writing in psychology, education, nursing, and sociology/ Beins

x, 202 hal.: tab.; 21 cm