Designs that talk and listen: Integrating functional information using voice-enabled CAD systems

In this paper, we report a novel approach to voice-enabled design synthesis and management. This approach consists of integrating “text-to-speech” and “speech-to-text” tools within a software prototype developed in MATLAB that connects seamlessly to a computer aided design software via an application program interface. Users can train the software to recognize specific words spoken by them and subsequently query for functions of individual parts or subassemblies. The results indicate the feasibility of interactive voice enabled product lifecycle management (PLM) tools in the future, where designing on the fly can be increasingly supported

Arbitrary Pole Placement with Sliding Mode Control

This paper considers the problem of placing all the poles arbitrarily for a linear time-invariant plant with the linear part 00 sliding mode control. We solve this problem in two ways. In the first approach, we design a sliding mode control by specifying the desired pole locations. The closed-loop system under this control law has all eigenvalues at the desired places. In the second approach, the sliding mode control is designed from a given state feedback gain so that all the poles of the closed-loop system are placed at the same location as that of the state feedback controller. Here, we provide a necessary and sufficient condition for the existence of a linear gain using the sliding mode control to achieve the desired pole assignment. This condition is always fulfilled for the single input case whereas it is only applicable for certain multi-input scenarios that meet the conditions stated in the paper. In both the approaches, one can place the closed-loop poles with the proposed sliding mode control at any arbitrary location in the left half of the complex plane, unlike with traditional design, where m poles are at the origin with m being the number of control inputs. A numerical example illustrates the proposed design methodology for sliding mode control

Characterization of shape and dimensional accuracy of incrementally formed titanium sheet parts with intermediate curvatures between two feature types

Single point incremental forming (SPIF) is a relatively new manufacturing process that has been recently used to form medical grade titanium sheets for implant devices. However, one limitation of the SPIF process may be characterized by dimensional inaccuracies of the final part as compared with the original designed part model. Elimination of these inaccuracies is critical to forming medical implants to meet required tolerances. Prior work on accuracy characterization has shown that feature behavior is important in predicting accuracy. In this study, a set of basic geometric shapes consisting of ruled and freeform features were formed using SPIF to characterize the dimensional inaccuracies of grade 1 titanium sheet parts. Response surface functions using multivariate adaptive regression splines (MARS) are then generated to model the deviations at individual vertices of the STL model of the part as a function of geometric shape parameters such as curvature, depth, distance to feature borders, wall angle, etc. The generated response functions are further used to predict dimensional deviations in a specific clinical implant case where the curvatures in the part lie between that of ruled features and freeform features. It is shown that a mixed-MARS response surface model using a weighted average of the ruled and freeform surface models can be used for such a case to improve the mean prediction accuracy within ±0.5 mm. The predicted deviations show a reasonable match with the actual formed shape for the implant case and are used to generate optimized tool paths for minimized shape and dimensional inaccuracy. Further, an implant part is then made using the accuracy characterization functions for improved accuracy. The results show an improvement in shape and dimensional accuracy of incrementally formed titanium medical implants

Effect of stress relieving heat treatment on surface topography and dimensional accuracy of incrementally formed grade 1 titanium sheet parts

The forming of parts with an optimized surface roughness and high dimensional accuracy is important in many applications of incremental sheet forming (ISF). To realize this, the effect of stress relieving heat treatment of grade-1 Ti parts performed before and after forming on the surface finish and dimensional accuracy was studied. It was found that heat treatment at a temperature of 540 °C for 2 h improves the surface finish of formed parts resulting in a surface with little or no visible tool marks. Additionally, it improves the dimensional accuracy of parts after unclamping from the rig used for forming, in particular, that of parts with shallow wall angles (typically <25°). It was also noted that post-forming heat treatment improves the surface finish of parts. The surface topography of formed parts was studied using interferometry to yield areal surface roughness parameters and subsequently using secondary electron imaging. Back-scatter electron microscopy imaging results coupled with energy-dispersive X-ray (EDX) analysis showed that heat treatment prior to forming leads to tool wear as indicated by the presence of Fe in samples. Furthermore, post-forming heat treatment prevents curling up of formed parts due to compressive stresses if the formed part is trimmed

Tool path generation for single point incremental forming using intelligent sequencing and multi-step mesh morphing techniques

A new methodology of generating optimized tool paths for incremental sheet forming is proposed in this work. The objective is to make parts with improved accuracy. To enable this, a systematic, automated technique of creating intermediate shapes using a morph mapping strategy is developed. This strategy is based on starting with a shape different from the final shape, available as a triangulated STL model, and using step-wise incremental deformation to the original mesh to arrive at the final part shape. Further, optimized tool path generation requires intelligent sequencing of partial tool paths that may be applied specifically to certain features on the part. The sequencing procedure is discussed next and case studies showing the application of the integrated technique are illustrated. The accuracy of the formed parts significantly improves using this integrated technique. The maximum deviations are brought down to less than 1 mm, while average absolute deviations of less than 0.5 mm are recorded

A new geometric proof of super-twisting control with actuator saturation

In this note, the stability of an uncertain system with actuator saturation using super-twisting controller (STC) is analysed. First, a new proof of STC ensuring finite-time stability of the system is proposed using geometric method which gives a new gain conditions. Then, using the proposed proof the domain of attraction (DOA) is explicitly calculated for the system with bounded control

Single point incremental forming: An assessment of the progress and technology trends from 2005 to 2015

The last decade has seen considerable interest in flexible forming processes. Among the upcoming flexible forming techniques, one that has captured a lot of interest is single point incremental forming (SPIF), where a flat sheet is incrementally deformed into a desired shape by the action of a tool that follows a defined toolpath conforming to the final part geometry. Research on SPIF in the last ten years has focused on defining the limits of this process, understanding the deformation mechanics and material behaviour and extending the process limits using various strategies. This paper captures the developments that have taken place over the last decade in academia and industry to highlight the current state of the art in this field. The use of different hardware platforms, forming mechanics, failure mechanism, estimation of forces, use of toolpath and tooling strategies, development of process planning tools, simulation of the process, aspects of sustainable manufacture and current and future applications are individually tracked to outline the current state of this process and provide a roadmap for future work on this process

Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments

Toll-like receptor (TLR)-2/TLR1 heterodimers recognize bacterial lipopeptides and initiate the production of inflammatory mediators. Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-receptors function, are still being discovered.Using shRNA, blocking antibodies, and fluorescent microscopy, we show that U937 macrophage responses to the TLR2/1 ligand, Pam(3)CSK(4), are dependent upon an integrin, α(3)β(1). The mechanism for integrin α(3)β(1) involvement in TLR2/1 signaling is through its role in endocytosis of lipopeptides. Using inhibitors of endosomal acidification/maturation and physical tethering of the ligand, we show that the endocytosis of Pam(3)CSK(4) is necessary for the complete TLR2/1-mediated pro-inflammatory cytokine response. We also show that TLR2/1 signaling from the endosome results in the induction of different inflammatory mediators than TLR2/1 signaling from the plasma membrane.Here we identify integrin α(3)β(1) as a novel regulator for the recognition of bacterial lipopeptides. We demonstrate that induction of a specific subset of cytokines is dependent upon integrin α(3)β(1)-mediated endocytosis of the ligand. In addition, we address an ongoing controversy regarding endosomal recognition of bacterial lipopeptides by demonstrating that TLR2/1 signals from within endosomal compartments as well as the plasma membrane, and that downstream responses may differ depending upon receptor localization. We propose that the regulation of endosomal TLR2/1 signaling by integrin α(3)β(1) serves as a mechanism for modulating inflammatory responses

Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis through the Induction of Tolerance

The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is essential for an effective activation of the immune response to this pathogen. The intracellular, cytosolic receptor Nod2 has been shown to play varying roles in either enhancing or attenuating inflammation in response to different infectious agents. We examined the role of Nod2 in responses to B. burgdorferi. In vitro stimulation of Nod2 deficient bone marrow derived macrophages (BMDM) resulted in decreased induction of multiple cytokines, interferons and interferon regulated genes compared with wild-type cells. However, B. burgdorferi infection of Nod2 deficient mice resulted in increased rather than decreased arthritis and carditis compared to control mice. We explored multiple potential mechanisms for the paradoxical response in in vivo versus in vitro systems and found that prolonged stimulation with a Nod2 ligand, muramyl dipeptide (MDP), resulted in tolerance to stimulation by B. burgdorferi. This tolerance was lost with stimulation of Nod2 deficient cells that cannot respond to MDP. Cytokine patterns in the tolerance model closely paralleled cytokine profiles in infected Nod2 deficient mice. We propose a model where Nod2 has an enhancing role in activating inflammation in early infection, but moderates inflammation after prolonged exposure to the organism through induction of tolerance