Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.

Interpreting direct-to-consumer genetic tests in the public health system: exploring the trade-offs.

Direct-to-consumer (DTC) genetic testing poses a growing problem in the field of health policy. Consumers who purchase the tests often do not have the knowledge required to interpret the tests and make informed decisions related to their care. They then turn to health care providers to interpret test results, many who also have limited knowledge of genetics. This may lead to decisions regarding further testing, treatment and referrals that do not benefit the patient and waste health care resources. Using interviews of stakeholders in the fields of health, genetics, education and ethics, I performed a thematic analysis to identify the key issues facing the health system in relation to DTC genetic testing. I then identified policy options available to the health system to aid physician decision-making. I evaluated the tradeoffs between the two most feasible policy options: promoting the Medical Genetics P&P telephone support line, and expanding HealthLink BC

A Child-Driven Metadata Schema: A Holistic Analysis of Children\u27s Cognitive Processes During Book Selection

The purpose of this study was to construct a child-driven metadata schema by understanding children\u27s cognitive processes and behaviors during book selection. Existing knowledge organization systems including metadata schemas and previous literature in the metadata domain have shown that there is a no specialized metadata schema that describes children\u27s resources that also is developed by children. It is clear that children require a new or alternative child-driven metadata schema. Child-driven metadata elements reflected the children\u27s cognitive perceptions that could allow children to intuitively and easily find books in an online cataloging system. The literature of development of literacy skills claims that the positive experiences of selecting books empower children\u27s motivation for developing literacy skills. Therefore, creating a child-driven metadata schema not only contributes to the improvement of knowledge organization systems reflecting children\u27s information behavior and cognitive process, but also improves children\u27s literacy and reading skills. Broader research questions included what metadata elements do children like to use? What elements should a child-driven metadata schema include? In order to answer these research questions, a triangulated qualitative research design consisting of questionnaires, paired think-aloud, interview, and diaries were used with 22 child participants between the ages of 6 and 9. A holistic understanding of the children\u27s cognitive processes during book selection as a foundation of a child-driven metadata schema displays an early stage of an ontological contour for a children\u27s knowledge organization system. A child-driven metadata schema constructed in this study is apt to include different metadata elements from those metadata elements existing in current cataloging standards. A child-driven metadata schema includes five classes such as story/subject, character, illustration, physical characteristics, and understandability, and thirty three metadata elements such as character\u27s names and images, book cover\u27s color, shape, textured materials, engagement element, and tone. In addition, the analysis of the relationship between emergent emotional vocabularies and cognitive factors and facets illustrated the important role of emotion and attention in children\u27s information processing and seeking behaviors

The growth of banking and financial institutions

A RJE article on the growth of banking and financial markets in the 1960's.The development of banking and financial institutions generally throughout the western world can best be understood by regarding banks essentially as an industry providing services to the community in which it is established and of which it forms a part. Banking services are strongly influenced by the whole economic environment in which the banks operate. Changes therein—whether these are cyclical fluctuations in the economy or structural changes—create the need for the banks to adapt themselves to the new situation. In this paper I wish to confine myself to structural changes only. These I propose to examine as a reflection of broad economic changes

Producing Navigable Knowledge Organization with Knowledge Interaction

Knowledge interaction combines concept theory, instantiation theory, and the taxonomy of knowledge elements to suggest that knowledge organization systems might be used effectively to integrate different dimensional representations of information objects. Understanding knowledge structurally as well as semantically can lead to a variety of implementations that might provide temporal interfaces for understanding relationships among information objects that are not obviously semantically related. An experimental test-­‐bed would rely on the actual experience of working scholars. Preliminary results come from a case study of the works of one prolific New Testament scholar whose works are available in digital form. We see clearly the distance between the theological positions, sociological interpretive positions, and methodological positions, indicating three interacting intellectual poles in this scholar’s writing

Analysis of metadata schemas for children's libraries

The purpose of this study is to evaluate two metadata schemas, AACR2+ and the International Children’s Digital Library’s metadata schema, in light of children’s information seeking behavior for book selection. While previous studies focus on the development of child-friendly interfaces, few of these studies discuss a metadata schema for children’s libraries. Given that effective information retrieval is based on well-constructed information organization, this study’s significance is its greater emphasis on information organization as a relevant factor than in previous studies. The methodology for this study consists of three parts: a meta-analysis of relevant research on children’s information seeking behaviors for book choices, a crosswalk of the metadata schemas, and a comparison of two data sets from the previous stages. The study finds that ICDL’s metadata schema tends to better reflect children’s unique information seeking behaviors for book choices as independent metadata elements than standard library cataloging does. Standard library cataloging tends to describe information reflecting children’s unique information seeking behaviors in a note area rather than describing in independent metadata elements. Therefore, by having independent and relevant metadata elements regarding the unique characteristics of children’s book choices, ICDL’s metadata schema provides more access points in a browse search system

Stress Processing Sensitivity in Reading Korean and English Words

PACLIC / The University of the Philippines Visayas Cebu College Cebu City, Philippines / November 20-22, 200