36 research outputs found
A. Sturcture-Activity studies of cyclic aza-Î’3-RGD peptide analogs.
International audienc
Preparation of Fmoc-Aza-Î’3-Pro-OH, Fmoc-Aza-Î’3-Asn-OH, Fmoc-Aza-Î’3-Asp-OH, Fmoc-Aza-Î’3-Glu-OH for Solid-Phase Syntheses of Aza-Î’3-Peptides
International audienc
Nouveaux mimes peptidiques de la séquence RGD incluant des unités aza-beta3-aminoacides
Poste
Aza-peptides and methods of use for the treatment and prevention of immunological disorders.
Peptides cycliques comprenant au moins un résidu aza-Β3-aminoacyle et leurs utilisations.
Pseudo-hexapeptides cycliques antimicrobiens : interactions lipidiques. Groupe d'études des Interactions Molécules.
Communication oral
Incorporation of aza-beta 3-amino acid into 26RFa(20-26), the endogenous ligand of GPR103: Structural Analysis.
PosterInternational audienc
Identification of SepCRP analogues in the cuttlefish Sepia officinalis: a novel family of ovarian regulatory peptides
In the cuttlefish, Sepia officinalis, the ovary appears to be one of the main sources of regulatory peptides involved in the successive steps of egg-laying. Following the identification of the SepCRP-1, which is a peptide extracted from ovary and involved in egg capsule secretion, investigations were focused on the identification of related peptides. Seven related-Sepia Capsule Releasing Peptides (R-SepCRPs) were identified by means of mass spectrometry and characterized using MS/MS spectra and/or Edman degradation. Finally, primary structures were verified by the comparison of MS/MS spectra from endogenic and synthetic peptides. This new ovarian peptide family exhibits a conserved SLXKD tag involved in the biological activity. LC-MS/MS screening clearly demonstrates that R-SepCRPs are restricted to the female genital tract. Expressed during vitellogenesis, they are released by vitellogenic follicles and full-grown oocytes (FGO) in the genital coelom. Biological activities suggest that R-SepCRPs would be responsible for the storage of FGO before mating and would take part in the mechanical secretion of egg capsule products, as previously described for SepCRP-1
Enhancement of Antimicrobial Activity of a Natural Antimicrobial Neuropeptide of Sepia officinalis.
International audienc