Simultaneous optical measurements of cell motility and growth

It has recently been shown that spatial light interference microscopy (SLIM) developed in our laboratory can be used to quantify the dry mass growth of single cells with femtogram sensitivity [M. Mir et al., Proc. Nat. Acad. Sci. 108, 32 (2011)]. Here we show that it is possible to measure the motility of single cells in conjunction with the dry mass measurements. Specifically the effect of poly-L-lysine substrate on the dry mass growth of Drosophila S2 cells is studied. By measuring the mean square displacement of single cells and clusters it is shown that cells that adhere better to the surface are unable to grow. Using such a technique it is possible to measure both growth and morphogenesis, two of the cornerstones of developmental biology

An Integrative Approach to Mindfulness-Based Symptom Management for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic health condition; its etiology is poorly understood, and treatment options are limited to management of symptoms. Current recommended treatment options are controversial, and evidence of effectiveness is limited. This paper proposes a novel model for symptom management of ME/CFS using mindfulness-based interventions, cognitive behavioural therapy (CBT), and relaxation techniques. A comprehensive review of available evidence is used to support this approach. The idea is that, working synergistically, these three approaches, grounded by mindfulness-based principles, can address many of the symptoms of the illness and help patients better cope and manage their day-to-day lives. This work is particularly important in a field that is under-researched and under-funded. There is still little understanding of pathology, or viable treatments, for ME/CFS patients. Yet there are millions of individuals afflicted with ME/CFS who deserve current scientifically-validated treatment options. In the absence of curative options, treatment alternatives must recognize the gravity of, and how best to address, the unique symptomology of the condition. The literature review suggests that the combined use of mindfulness, CBT and restorative yoga can be effective in individual symptom management for ME/CFS. However, the limitations are that this three-pronged model has not yet been empirically tested. This project leaves the door open for, and establishes the importance of, future research

Torts—Tavernkeeper\u27s Liability for Act of Guest

In Miller v. Staton, the members of the Washington Supreme Court disagree on how properly to apply the general rule that a tavernkeeper owes the duty to his guests to exercise reasonable care to protect them from injury at the hands of a fellow guest

Contracts—Earnest-Money Payments—Vendee\u27s Recovery Denied Where Agreement Fails to Comply with Statute of Frauds

In Schweiter v. Halsey, the Washington Supreme Court held that if a vendor of real property has not repudiated, but is ready, willing and able to perform, the vendee cannot recover payments made upon the purchase price although the earnest-money agreement does not satisfy the Statute of Frauds

Once Upon a Mattress (October 13-29, 1978)

Program for Once Upon a Mattress (October 13-29, 1978)

Common Problems, Different Solutions : Learningfrom International Approaches to Improving MedicalServices Access for Underserved Populations

Canada shares with most OECD countries the problems associated with inequitable geographic access to physician services, and improving the geographic distribution of physicians is a policy preoccupation of all ministries of health in Canada today. Recent court challenges by newly-entering physicians to physician supply controls in B. C. and New Brunswick have brought the issue into sharp relief. The authors explore the degree to which the provinces have adopted common approaches to addressing these problems, and whether Canadian policy-makers have learned from international experience. The recent judgment in the Waldman case in B.C. is analyzed in terms of likely implications for future policies on the geographic distribution of physicians in Canada. The authors conclude that the B.C. and New Brunswick cases may lead to broad changes in health care policy direction by severely limiting the range of narrowly targeted policy options available to ministries of health across Canada