Cinema Home

Dada la coyuntura actual, es decir, la crisis por la pandemia por covid - 19, y a consecuencia de ello, el aislamiento social. Muchos de los negocios se han visto afectados, siendo uno de ellos, el sector de entretenimiento, específicamente el que involucra la proyección de contenido audiovisual. Muchas de las películas, eventos, obras, conciertos, entre otros a suscitar entre los años 2020 y 2021 se han visto afectadas y por lo tanto, postergadas. Por esta razón, nace el proyecto “Cinema Home”, esta idea de negocio se basa en implementar un servicio de alquiler de equipos de proyección y accesorios complementarios, los cuales serán de fácil uso y acceso para el hogar. Este proyecto tiene como objetivo fundamental, ofrecer al usuario una alternativa distinta en la experiencia en tamaño de imagen, sonido y que el público disfrute de un momento agradable y de distracción junto a sus amigos o familiares. Por lo tanto, el presente informe tiene como objetivo demostrar la viabilidad de este proyecto a partir de una serie de experimentos que nos permitirán medir el interés de nuestros clientes potenciales. Todo ello, a partir de identificar los aspectos fundamentales de nuestro servicio a partir del desarrollo de la herramienta de Business Model Canvas y un estudio de mercado.Given the current situation, that is, the crisis due to the covid-19 pandemic, and as a consequence, social isolation. Many of the businesses have been affected, one of them being the entertainment sector, specifically the one that involves the projection of audiovisual content. Many of the films, events, plays, concerts, among others to arouse between 2020 and 2021 have been affected and therefore postponed. For this reason, the "Cinema Home" project was born, this business idea is based on implementing a rental service for projection equipment and complementary accessories, which will be easy to use and access for the home. The main objective of this project is to offer the user a different alternative in terms of image size, sound and that the public enjoy a pleasant and distracting moment with their friends or family. Therefore, this report aims to demonstrate the feasibility of this project based on a series of experiments that will allow us to measure the interest of our potential clients. All this, from identifying the fundamental aspects of our service from the development of the Business Model Canvas tool and a market study.Trabajo de investigació

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality