Growth Effects of Some Platinum(II) Complexes with Sulfur-Containing Carrier Ligands on MCF7 Human Breast Cancer Cell Line upon Simultaneous Administration with Taxol

The platinum (II)complexes, cis-[PtCl2(CH3SCH2CH2SCH3)] (Pt1), cis-[PtCl2(dmso)2] (dmso is dimethylsulfoxide; Pt2) and cis-[PtCl2(NH3)2] (cisplatin), and taxol (T) have been tested at different equimolar concentrations. Cells were exposed to complexes for 2 h and left to recover in fresh medium for 24, 48 or 72 h. Growth inhibition was measured by tetrazolium WST1 assay Analyses of the cell cycle, and apoptosis were performed by flow cytometry, at the same exposure times. The IC50 value of each platinum(II) complex as well as combination index (CI; platinum(II) complex + taxol) for various cytotoxicity levels were determined by median effects analysis

Microcystins: Potential risk factors in carcinogenesis of primary liver cancer in Serbia

The Primary Liver Carcinoma (PLC) is one of the most common malignant diseases in the world. In Central Serbia during the period from 2000 to 2006 the average incidence was 16.9/100 000 that complies to the European epidemiology. The main risk factors for PLC are considered to be cirrhosis of liver and viral chronic Hepatitis B and C. The goal of this research was to analyze epidemiological data of these diseases and to state the correlation between PLC, liver cirrhosis and Hepatitis B and C in Serbia. During the research period of 6 years the correlations between PLC and the corresponding risk factors were negative. For this reason it was necessary to examine other risk factors. The high incidence of PLC in Nišavski, Toplički and Šumadijski region correlate with emerging blooms of Cyanobacteria in water reservoirs supplying these areas with drinking water. Since we examined only 7 years span and have no completed cyanotoxin analysis, it is necessary to complete more research in this field. The identification of cyanotoxins as risk factors that contribute to the development of liver cancer will help in the prevention of this disease

Putevi izloženosti ljudi cijanotoksinima i njihovi utjecaji na zdravlje

Cyanotoxins are secondary metabolites produced by cyanobacteria. They pose a threat to human health and the environment. This review summarises the existing data on human exposure to cyanotoxins through drinking water, recreational activities (e.g., swimming, canoeing or bathing), the aquatic food web, terrestrial plants, food supplements, and haemodialysis. Furthermore, it discusses the tolerable daily intake and guideline values for cyanotoxins (especially microcystins) as well as the need to implement risk management measures via national and international legislation.Cijanotoksini su sekundarni metaboliti potencijalno opasni za ljudsko zdravlje i okoliš, koje proizvodecijanobakterije. Ovaj pregledni rad donosi prikaz postojećih podataka o izloženosti ljudi cijanotoksinima putem vode za piće, rekreacije, vodenog hranidbenog lanca, kopnenih biljaka i nekih drugih specifičnih puteva (dodaci prehrani i intravenozni put). Nadalje, u njemu se raspravlja o dopuštenom dnevnom unosu (TDI) i preporučenim vrijednostima za cijanotoksine (naročito mikrocistine) i nužnost provedbe mjera upravljanja rizicima putem nacionalnih i međunarodnih zakona. To su mjere od najveće važnosti za očuvanje okoliša i ljudskog zdravlja

Agricultural waste: a source of bioactive compounds for potential application in meat products

Globalization and population growth have led to the development of a modern agricultural system that currently produces millions of tons of waste. This waste is disposed of by burning, dumping or accumulating in landfills, resulting in environmental, health, and economic issues. The agro‑industrial residues are abundant with phenolic bioactive compounds, such as phenolic acids, flavonoids, tannins, and carotenoids, which, among others, exhibit antioxidant and antimicrobial capacities and have good potential as food flavorings and colorants. The most common method for isolating these compounds is solvent extraction. However, there is a trend towards eco‑innovative extraction methods that offer better possibilities for implementation on an industrial scale. The oxidation of lipids and proteins is one of the main causes of quality deterioration in meat and meat products during processing and storage. Therefore, the application of natural antioxidants extracted from these new, unconventional raw materials could be a sustainable alternative to synthetic antioxidants. This review summarizes the data on natural antioxidants derived from agro‑industrial by‑products and their incorporation in various meat product formulations. It also addresses limiting factors related to safety and changes in sensory properties

Inteligentni robotski sistemi za ekstremno diverzifikovanu proizvodnju

U okviru ovog rada navode se rezultati sprovedenih istraživanja na četvorogodišnjem projektu TR35007 koji zajednički realizuju Mašinski fakultet Univerziteta u Beogradu, Fakultet tehničkih nauka Univerziteta u Novom Sadu i kompanija Ikarbus iz Beograda. Ovaj projekat finansijskih podržava Ministarstvo prosvete i nauke u okviru četovorogodišnjeg ciklusa istraživačkih projekata za tehnološki razvoj, od 2011. do 2014. godine. Prvo se navode istraživački okvir projekta, osnovni ciljevi koji postavljeni pred istraživački tim i organizacija projekta koja je izvedena po modelu radnih paketa. U drugom delu rada navode se osnovni rezultati ostvaranih u prvoj istraživačkoj godini, sa odgovarajućim opisom i osnovnim detaljima tehničke i organizacione prirode

Nikola Tesla discovered ‘very special radiation’ or x-radiation

Nikola Tesla was an ingenious and briliant scintifist which contributed to the science and technology prosperity of the world. Nikola Tesla discovered high frequency oscillator 1891 year, and afterwards, single electrode X-ray tube without target electrode, electron (“particles charged with electricity”), Bremsstrahlung or “breaking radiation” or “very special radiation” (X-radiation) in 1892 year, biological hazards of X-rays, and more about 700 inventions, and 112 patents. Tesla's research work in the field of X-rays was stopped in 1895 because burned in his laboratory. When W. C. Röntgen 1895, recognition X-rays, Tesla restored his work on this field and sent Röntgen a telegram with congratilations and Röntgen shows obtained with X-ray tubes which operated with high frequency currents. Tesla discovered many secret of nature

Restricted permutations

In this thesis we study different methods of counting a large number of combinatorial objects: permutations, variations, combinations, subsets, with some additional restrictions. We have developed a completely new method for the enumeration of some of these objects and make connections among some of them. We estimate the algorithmic complexity of the new method and analyze what is better than existing ones. We have entered a hundred new sequences in Slone’s Online encyclopedia of integer sequences and provided comments on the large number of existing sequences

Correspondence to:

Nikola Tesla was an ingenious and briliant scintifist which contributed to the science and technology prosperity of the world. Nikola Tesla discovered high frequency oscillator 1891 year, and afterwards, single electrode X-ray tube without target electrode, electron („particles charged with electricity“), Bremsstrahlung or „breaking radiation “ or „very special radiation“ (X-radiation) in 1892 year, biological hazards of X-rays, and more about 700 inventions, and 112 patents. Tesla's research work in the field of X-rays was stoped in 1895 becouse burned in his laboratory. When W. C. Röntgen 1895, recognition X-rays, Tesla restored his work on this field and sent Röntgen a telegram with congratilations and Röntgen shows obtained with X-ray tubes which operated with high frequency currents. Tesla discovered many secret of nature. Key words: Nikola Tesla; X-Ray; Tesla's Oscillator; Vacuum Tubes; Biological Hazards „I think that the work of Nikola Tesla at that time and his great idea of rotating magnetic field is one of the greatest fields of human imagination in the history of human kind. That work of his enabled the discovery of x-rays, as well as all of work all over the world performed by J. J. Thompson and others, which brought to the concept of modern physics.