957 research outputs found
Microglia form satellites with different neuronal subtypes in the adult murine central nervous system
Microglia are the innate immune cells of the central nervous system (CNS). In the adult uncompromised CNS, they have a highly ramified morphology and continuously extend and retract their processes. A subpopulation of microglial cells forms close soma-to-soma contacts with neurons and have been termed satellite microglia, yet the role of such interaction is largely unknown. Here, we analyzed the distribution of satellite microglia in different areas of the CNS of adult male mice applying transgenic- and immunolabeling of neuronal subtypes and microglia followed by three-dimensional imaging analysis. We quantified satellite microglia associated with GABAergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar Purkinje cell neurons. Satellite microglia in the retina were assessed qualitatively. Microglia form satellites with all neuronal subtypes studied, whereas a preference for a specific neuron subtype was not found. The occurrence and frequency of satellite microglia is determined by the histo-architectural organization of the brain area and the densities of neuronal somata therein
Synthesis and Characterization of Electro-Explosive Magnetic Nanoparticles for Biomedical Applications
Nowadays there are new magnetic nanostructures based on bioactive metals with low toxicity and high efficiency for a wide range of biomedical applications including drugs delivery, antimicrobial drugs design, cells' separation and contrasting. For such applications it is necessary to develop highly magnetic particles with less than100 nm in size. In the present study magnetic nanoparticles Fe, Fe[3]O[4] and bimetallic Cu/Fe with the average size of 60- 90 nm have been synthesized by electrical explosion of wire in an oxygen or argon atmosphere. The produced nanoparticles have been characterized with transmission electron microscopy, X-ray phase analysis, and nitrogen thermal desorption. The synthesized particles have shown antibacterial activity to gram-positive (S. aureus, MRSA) and gramnegative (E. coli, P. aeruginosa) bacteria. According to the cytological data Fe, Fe[3]O[4]and Cu/Fe nanoparticles have effectively inhibited viability of cancer cell lines Neuro-2a and J774. The obtained nanoparticles are promising for new antimicrobial drugs and antitumor agents' developmen
Synthesis and Characterization of Electro-Explosive Magnetic Nanoparticles for Biomedical Applications
Nowadays there are new magnetic nanostructures based on bioactive metals with low toxicity and high efficiency for a wide range of biomedical applications including drugs delivery, antimicrobial drugs design, cells' separation and contrasting. For such applications it is necessary to develop highly magnetic particles with less than100 nm in size. In the present study magnetic nanoparticles Fe, Fe[3]O[4] and bimetallic Cu/Fe with the average size of 60- 90 nm have been synthesized by electrical explosion of wire in an oxygen or argon atmosphere. The produced nanoparticles have been characterized with transmission electron microscopy, X-ray phase analysis, and nitrogen thermal desorption. The synthesized particles have shown antibacterial activity to gram-positive (S. aureus, MRSA) and gramnegative (E. coli, P. aeruginosa) bacteria. According to the cytological data Fe, Fe[3]O[4]and Cu/Fe nanoparticles have effectively inhibited viability of cancer cell lines Neuro-2a and J774. The obtained nanoparticles are promising for new antimicrobial drugs and antitumor agents' developmen
Preparation of nano/micro bimodal aluminum powder by electrical explosion of wires
Electrical explosion of aluminum wires has been shown to be a versatile method for the preparation of bimodal nano/micro powders. The energy input into the wire has been found to determine the relative content of fine and coarse particles in bimodal aluminum powders. The use of aluminum bimodal powders has been shown to be promising for the development of high flowability feedstocks for metal injection molding and material extrusion additive manufacturing
Investigation of the peculiarities of oxidation of Ti/Al nanoparticles on heating to obtain TiO2/Al2O3 composite nanoparticles
The creation of new nanomaterials with improved characteristics, as well as the development of new approaches to obtain such materials is an urgent task in science and technology. One of the promising directions in obtaining improved nanomaterials is the use of precursors in the form of multicomponent metal nanoparticles. Thermal oxidation of bimetallic Ti/ Al nanoparticles obtained by electrical explosion of wires was investigated in this work. Ti/Al nanoparticles have been found to be completely oxidized with the formation of composite TiO2/ Al2O3 nanoparticles after calcination at 900 Β°C. The formation of TiO2 phase with a rutile structure on heating to 500 Β°C, and the formation of TiO2 phases with a rutile and anatase structure, as well as Ξ±-Al2O3 on heating to 700 Β°C have been established, in addition to the residue of unoxidized metals. Complete oxidation of Ti/Al nanoparticles occurs when heated to 900 Β°C. The photochemical activity of TiO2/ Al2O3 composite nanoparticles obtained at 900 Β°C was studied. The degradation of methyl orange dye reached 55% under UV irradiation for 120 min
Ξ£+ and Β―Ξ£β Polarization in the J/Ο and Ο(3686) Decays
From 1310.6Γ106ββJ/Ο and 448.1Γ106ββΟ(3686) events collected with the BESIII experiment, we report the first observation of Ξ£+ and Β―Ξ£β spin polarization in e+eββJ/Ο[Ο(3686)]βΞ£+Β―Ξ£β decays. The relative phases of the form factors ΞΞ¦ have been measured to be (β15.5Β±0.7Β±0.5)Β° and (21.7Β±4.0Β±0.8)Β° with J/Ο and Ο(3686) data, respectively. The nonzero value of ΞΞ¦ allows for a direct and simultaneous measurement of the decay asymmetry parameters of Ξ£+βpΟ0(Ξ±0=β0.998Β±0.037Β±0.009) and Β―Ξ£ββΒ―pΟ0(Β―Ξ±0=0.990Β±0.037Β±0.011), the latter value being determined for the first time. The average decay asymmetry, (Ξ±0βΒ―Ξ±0)/2, is calculated to be β0.994Β±0.004Β±0.002. The CP asymmetry ACP,Ξ£=(Ξ±0+Β―Ξ±0)/(Ξ±0βΒ―Ξ±0)=β0.004Β±0.037Β±0.010 is extracted for the first time, and is found to be consistent with CP conservatio
Chemical behaviour of Al/Cu nanoparticles in water
Bimetallic Al/Cu nanoparticles with Al/Cu composition 10:90, 20:80, 40:60 were produced by method of simultaneous electrical explosion of metal pairs in the argon atmosphere. Nanopowders containing 20% and 40% (mass) of aluminum interacted with water at 40β70Β Β°C and formed composite particles that were porous structures of nanopetal pseudoboehmite with nanosized copper-containing inclusions inside. Aluminum in nanopowder with Al/Cu composition 10:90 did not react with water, as far as it is in the phase of intermetallic compounds Π‘uAl2 and Π‘u4Al9. Nanocomposite produced can be used as an active component of antibacterial agents
ΠΠΈΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΠ΅ ΡΠ½ΡΡ-Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡΡ Zno-ag Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ in vitro
Background. Nanoparticles (NPs) of zinc and silver oxide are promising antitumor agents, the use of which can enhance modern approaches to cancer treatment. Using bicomponent ZnO-Ag nanoparticles, one can increase the efficiency due to the occurrence of a synergistic antitumor effect. Among the main physicochemical properties that affect the antitumor activity of nanoparticles, one can distinguish their size and distribution of components inside the particle or their microstructure, however, these aspects are currently poorly understood.The aim of this study is the synthesis of ZnO-Ag nanoparticles using electrical explosive of wire technology and the in vitro study of the antitumor activity of NPs against breast ductal adenocarcinoma MCF-7 (ATCC HTB-22) and the HeLa cell line isolated from a cervical tumor.Material and Methods. ZnO-Ag nanoparticles were obtained by simultaneous electric explosion of zinc and silver twisted wires in a gas mixing atmosphere: argon and oxygen. The content of the components was regulated by varying the wire diameters. Physicochemical properties were studied using X-ray phase analysis, thermal desorption of nitrogen, and transmission electron microscopy. Antitumor activity in vitro was studied using the MTT test against HeLa and MCF-7 cell lines.Results. As a result of an electric explosion of twisted wires in an argon + oxygen gas mixture, ZnO-Ag NPs with different contents of components and the structure of Janus nanoparticles were obtained. The study of the physicochemical properties of nanoparticles showed that an increase in the silver content led to a decrease in the average particle size, an increase in their specific surface area, an increase in their photochemical activity and the ability to generate reactive oxygen species. The high antitumor activity of nanoparticles with a minimum silver content can be explained by a decrease in the size of silver fragments from 46 nm to 23 nm and a decrease in the average particle size from 92 nm to 54 nm. A decrease in the size of NPs and their components contributes to an increase in their solubility and, accordingly, cytotoxicity. In addition, a decrease in the size of crystallites makes it possible to increase the number and length of the ZnO-Ag interface.Conclusion. In the present study, bicomponent ZnOβAg NPs were synthesized using the joint electric explosion of zinc and silver wires in a mixed atmosphere of argon and oxygen. A study of the physicochemical properties of nanoparticles was carried out and it was found that they all have the structure of Janus nanoparticles, an average size of 54 to 92 nm, and photochemical activity and the ability to generate ROS. Using the MTT test, the antitumor activity of NPs was confrmed using MCF-7 and HeLa cell lines. The high effciency of ZnO-Ag NPs containing 20% wt. silver indicates the possibility of using these NPs in antitumor therapy.Β ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠ°Π½ΠΎΡΠ°ΡΡΠΈΡΡ ΠΎΠΊΡΠΈΠ΄Π° ΡΠΈΠ½ΠΊΠ° ΠΈ ΡΠ΅ΡΠ΅Π±ΡΠ° ΡΠ²Π»ΡΡΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΡΡ
ΠΌΠΎΠΆΠ΅Ρ ΡΡΠΈΠ»ΠΈΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΠΊΠ°. ΠΡΠΈΠΌΠ΅Π½ΡΡ Π±ΠΈΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΠ΅ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡΡ ZnO-Ag, ΠΌΠΎΠΆΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΠΈΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ°. Π‘ΡΠ΅Π΄ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ², Π²Π»ΠΈΡΡΡΠΈΡ
Π½Π° ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ, ΠΌΠΎΠΆΠ½ΠΎ Π²ΡΠ΄Π΅Π»ΠΈΡΡ ΠΈΡ
ΡΠ°Π·ΠΌΠ΅Ρ ΠΈ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π²Π½ΡΡΡΠΈ ΡΠ°ΡΡΠΈΡΡ ΠΈΠ»ΠΈ ΠΈΡ
ΠΌΠΈΠΊΡΠΎΡΡΡΡΠΊΡΡΡΡ, ΠΎΠ΄Π½Π°ΠΊΠΎ Π΄Π°Π½Π½ΡΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ Π΄ΠΎ ΡΠΈΡ
ΠΏΠΎΡ ΡΠ²Π»ΡΡΡΡΡ ΠΌΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΠΌΠΈ.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΠ½ΡΠ΅Π· Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ZnO-Ag ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ²Π·ΡΡΠ²Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ in vitro ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠ§ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΏΡΠΎΡΠΎΠΊΠΎΠ² ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ MCF-7 (ATCC HTB-22) ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π»ΠΈΠ½ΠΈΠΈ HeLa.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ZnO-Ag ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΡΠΉ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π²Π·ΡΡΠ² ΡΠΊΡΡΡΠΊΠΈ ΠΏΡΠΎΠ²ΠΎΠ»ΠΎΠΊ ΡΠΈΠ½ΠΊΠ° ΠΈ ΡΠ΅ΡΠ΅Π±ΡΠ° Π² ΡΠΌΠ΅ΡΠ°Π½Π½ΠΎΠΉ Π°ΡΠΌΠΎΡΡΠ΅ΡΠ΅ Π°ΡΠ³ΠΎΠ½Π° ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°. Π€ΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΠ°Π·ΠΎΠ²ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°, ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΠΎΡΠ±ΡΠΈΠΈ Π°Π·ΠΎΡΠ°, ΠΏΡΠΎΡΠ²Π΅ΡΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ. ΠΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ in vitro ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΠΠ’Π’ΡΠ΅ΡΡΠ° Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΈΠ½ΠΈΠΉ HeLa ΠΈ MCF-7.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π·ΡΡΠ²Π° ΡΠΊΡΡΡΠΊΠΈ ΡΠΈΠ½ΠΊΠΎΠ²ΠΎΠΉ ΠΈ ΡΠ΅ΡΠ΅Π±ΡΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ²ΠΎΠ»ΠΎΠΊ Π² Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠΌΠ΅ΡΠΈ Π°ΡΠ³ΠΎΠ½ + ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΠ§ ZnO-Ag Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈ ΡΡΡΡΠΊΡΡΡΠΎΠΉ ΡΠ½ΡΡ-Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΠ΅ΡΠ΅Π±ΡΠ° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΡΠ°ΡΡΠΈΡ, ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΈΡ
ΡΠ΄Π΅Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ, ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΈΡ
ΡΠΎΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠΎΠ²Π°ΡΡ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°. ΠΡΡΠΎΠΊΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠ§ Ρ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠ΅Π±ΡΠ° ΠΌΠΎΠΆΠ½ΠΎ ΠΎΠ±ΡΡΡΠ½ΠΈΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΡΠ΅ΡΠ΅Π±ΡΠ° Ρ 46 Π΄ΠΎ 23 Π½ΠΌ ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΡΠ°ΡΡΠΈΡ Ρ 92 Π΄ΠΎ 54 Π½ΠΌ. Π‘Π½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΠΠ§ ΠΈ ΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΈΡ
ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΠΈ ΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΠΊΡΠΈΡΡΠ°Π»Π»ΠΈΡΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΈ ΠΏΡΠΎΡΡΠΆΠ΅Π½Π½ΠΎΡΡΡ Π³ΡΠ°Π½ΠΈΡΡ ΡΠ°Π·Π΄Π΅Π»Π° ΡΠ°Π· ZnO-Ag.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΈΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΠ΅ ΠΠ§ ZnO-Ag Π±ΡΠ»ΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π·ΡΡΠ²Π° ΡΠΈΠ½ΠΊΠΎΠ²ΠΎΠΉ ΠΈ ΡΠ΅ΡΠ΅Π±ΡΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ²ΠΎΠ»ΠΎΠΊ Π² ΡΠΌΠ΅ΡΠ°Π½Π½ΠΎΠΉ Π°ΡΠΌΠΎΡΡΠ΅ΡΠ΅ Π°ΡΠ³ΠΎΠ½Π° ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°. ΠΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΎΠ½ΠΈ ΠΈΠΌΠ΅ΡΡ ΡΡΡΡΠΊΡΡΡΡ ΡΠ½ΡΡ-Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ, ΡΡΠ΅Π΄Π½ΠΈΠΉ ΡΠ°Π·ΠΌΠ΅Ρ ΠΎΡ 54 Π΄ΠΎ 92 Π½ΠΌ, ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΡΠΎΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠΎΠ²Π°ΡΡ ΠΠ€Π. ΠΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΠΠ’Π’-ΡΠ΅ΡΡΠ° ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠ§ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΈΠ½ΠΈΠΉ MCF-7 ΠΈ HeLa. ΠΡΡΠΎΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠ§ ZnO-Ag, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
20 % ΡΠ΅ΡΠ΅Π±ΡΠ°, ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΡΡ
ΠΠ§ Π² ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ.
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