Evolution of the Dark Matter Distribution with 3-D Weak Lensing

We present a direct detection of the growth of large-scale structure, using weak gravitational lensing and photometric redshift data from the COMBO-17 survey. We use deep R-band imaging of two 0.25 square degree fields, affording shear estimates for over 52000 galaxies; we combine these with photometric redshift estimates from our 17 band survey, in order to obtain a 3-D shear field. We find theoretical models for evolving matter power spectra and correlation functions, and fit the corresponding shear correlation functions to the data as a function of redshift. We detect the evolution of the power at the 7.7 sigma level given minimal priors, and measure the rate of evolution for 0<z<1. We also fit correlation functions to our 3-D data as a function of cosmological parameters sigma_8 and Omega_Lambda. We find joint constraints on Omega_Lambda and sigma_8, demonstrating an improvement in accuracy by a factor of 2 over that available from 2D weak lensing for the same area.Comment: 11 pages, 4 figures; submitted to MNRA

Reliability of Diagnostic Tests for Helicobacter pylori Infection

Introduction. Helicobacter pylori (H. pylori) infection is very common worldwide. A reliable diagnosis is crucial for patients with H. pylori-related diseases. At followup, it is important to confirm that eradication therapy has been successful. There is no established gold standard for the diagnosis of H. pylori infection. Material and Methods. A sample of 304 volunteers from the general population was screened for H. pylori infection with serology, 13C-urea breath test (UBT), rapid urease test (RUT) on fresh biopsy, culture from biopsy, and histological examination. Culture was used as gold standard. Results. The sensitivity was 0.99 for serology, 0.90 for UBT, 0.90 for RUT, and 0.90 for histological examination. Corresponding specificities were 0.82, 0.99, 0.98, and 0.97, respectively. The accuracy was 0.86 for serology, 0.96 for UBT, 0.95 for RUT, 0.93 for culture, and 0.95 for histology. There was a strong correlation between the results of UBT and the histological scores of H. pylori colonisation as well as between the results of UBT and the scores of RUT. Conclusion. There were only minor differences in accuracy between the three invasive tests for H. pylori infection in this population. RUT may be recommended as the first choice since a result is obtained within hours. The accuracy of UBT was comparable to the invasive tests, and it is recommended for situations when endoscopy is not needed

Identification and profiling of salinity stress-responsive proteins in Sorghum bicolor seedlings

Sorghum bicolor, a drought tolerant cereal crop, is not only an important food source in the semi arid/arid regions but also a potential model for studying and gaining a better understanding of the molecular mechanisms of drought and salt stress tolerance in cereals. In this study, seeds of a sweet sorghumvariety, MN1618, were planted and grown on solid MS growth medium with or without 100mM NaCl. Heat shock protein expression immunoblotting assays demonstrated that this salt treatment induced stress within natural physiological parameters for our experimental material. 2D PAGE in combination with MS/MS proteomics techniques were used to separate, visualise and identify salinity stress responsive proteins in young sorghum leaves. Out of 281 Coomassie stainable spots, 118 showed statistically significant responses (p<0.05) to salt stress treatments. Of the 118 spots, 79 were selected for tandem mass spectrometric identification, owing to their good resolution and abundance levels, and of these, 55 were positively identified. Identified proteins were divided into six functional categories including both known and novel/putative stress responsive proteins. Molecular and physiological functions of some of our proteins of interest are currently under investigation via bioinformatic and molecular biology approaches.Web of Scienc

A palaeolimnological study of Lake Vastadtjern, Norway

This project reports on analysis of a set of sediment cores collected from Lake Vastadtjern in Norway in 2013-2014, spanning a total sediment depth of c. 600 cm. Multi-proxy palaeoecological techniques, principally diatoms, macrofossils and Cladocera, were employed to assess environmental change at the lake over the last c. 6000 years. The project aims to determine ecological and chemical reference conditions of the lake to help inform the setting of reference conditions for catchments dominated by clay-rich soils