Pulmonary Edema: A Pictorial Review of Imaging Manifestations and Current Understanding of Mechanisms of Disease

Pulmonary edema is a common clinical entity caused by the extravascular movement of fluid into the pulmonary interstitium and alveoli. The four physiologic categories of edema include hydrostatic pressure edema, permeability edema with and without diffuse alveolar damage (DAD), and mixed edema where there is both an increase in hydrostatic pressure and membrane permeability. As radiographic manifestations and etiologies are varied, an appreciation for both the common and uncommon manifestations and causes of pulmonary edema is essential for accurate diagnosis

Globalization and ICF Eugenics: Historical coincidence or connection? The More Things Change the More They Stay the Same

No abstract availabl

Flavinylation of the precursor of mitochondrial dimethylglycine dehydrogenase by intact and solubilised mitochondria

The flavinylation and the presequence processing of the mitochondrial matrix enzyme dimethylglycine dehydrogenase (Me2GlyDH) were investigated with the reticulocyte lysate translated precursor (pMe2GlyDH) added to solubilised mitoplasts of rat liver mitochondria. The flavinylation of pMe2GlyDH was strictly dependent on the addition of mitochondrial protein(s), among which the mitochondrial flavinylation stimulating factor [Brizio C., et al. (2000) Eur. J. Biochem 267, 4346–4354], that actively promotes holo‐Me2GlyDH formation. The precursor processing, that accompanies the biogenesis of the enzyme, was not required to allow the flavinylation to proceed. The comparison of the time course of the flavinylation and the processing of pMe2GlyDH demonstrated that the covalent attachment of the flavin moiety preceded the presequence processing by mitochondrial processing peptidase

Ice Storm Experiences of Persons with Disabilities: Knowledge is Safety

Questionnaire responses of ice storm victims with and without disabilities were compared and 15 women with disabilities were interviewed about their experiences. Results are examined from the Social Model of Disability perspective in terms of dealing with unexpected environmental barriers to inclusion

Computer use by students with disabilities perceived advantages, problems and solutions

Titre de l'écran-titre (visionné le 4 oct. 2013)Bibliogr

A Regulatory Role of NAD Redox Status on Flavin Cofactor Homeostasis in S. cerevisiae

Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccharomyces cerevisiae. We investigated here the ability of isolated mitochondria to degrade externally added FAD and NAD (in both its reduced and oxidized forms). A set of kinetic experiments demonstrated that mitochondrial FAD and NAD(H) destroying enzymes are different from each other and from the already characterized NUDIX hydrolases. We studied here, in some detail, FAD pyrophosphatase (EC 3.6.1.18), which is inhibited by NAD+ and NADH according to a noncompetitive inhibition, with Ki values that differ from each other by an order of magnitude. These findings, together with the ability of mitochondrial FAD pyrophosphatase to metabolize endogenous FAD, presumably deriving from mitochondrial holoflavoproteins destined to degradation, allow for proposing a novel possible role of mitochondrial NAD redox status in regulating FAD homeostasis and/or flavoprotein degradation in S. cerevisiae

Overview on Reproductive Endocrine Aspects in Buffalo

Buffalo is an important worldwide species in terms of milk and meat production as well as draft. The majorconstraints to full exploitation of the productive potential of buffalo are its inherent low reproductive efficiency due todelayed puberty, higher age at first calving, long post partum anoestrus period, long intercalving period, silent heatcoupled with poor expression of oestrus, seasonality in breeding and low conception rate. Reproductive cycles in buffaloare regulated by endocrine-neuroendocrine interactions between hypothalamic, gonadotropic, gonadal and otherhormones. To improve the buffalo reproductive efficiency, the investigation on endocrine aspects is useful to gain abetter knowledge of buffalo reproduction. This review is focused on the information available on various basic hormones(Melatonin, Progesterone (P4), Estradiol 17B (E2), Follicle stimulating hormone (FSH), Luteinizing hormone (LH)) and onnew hormones (Inhibin, Glycoproteins associated with pregnancy (PAGs), Leptin) related to reproductive function