1,284 research outputs found
Limits on the Dipole Moments of the -Lepton via the Process $e^{+}e^{-}\to \tau^+ \tau^- \gamma in a Left-Right Symmetric Model
Limits on the anomalous magnetic moment and the electric dipole moment of the
lepton are calculated through the reaction at the -pole and in the framework of a left-right symmetric model.
The results are based on the recent data reported by the L3 Collaboration at
CERN LEP. Due to the stringent limit of the model mixing angle , the
effect of this angle on the dipole moments is quite small.Comment: 15 pages, 3 figure
The performance of simulated annealing in parameter estimation for vapor-liquid equilibrium modeling
A systematic review of randomised controlled trials on the effectiveness of exercise programs on lumbo pelvic pain among postnatal women
Background: A substantial number of women tend to be affected by Lumbo Pelvic Pain (LPP) following child birth.
Physical exercise is indicated as a beneficial method to relieve LPP, but individual studies appear to suggest mixed
findings about its effectiveness. This systematic review aimed to synthesise evidence from randomised controlled trials on the effectiveness of exercise on LPP among postnatal women to inform policy, practice and future research.
Methods: A systematic review was conducted of all randomised controlled trials published between January 1990 and July 2014, identified through a comprehensive search of following databases: PubMed, PEDro, Embase, Cinahl, Medline, SPORTDiscus, Cochrane Pregnancy and Childbirth Groupâs Trials Register, and electronic libraries of authorsâinstitutions.
Randomised controlled trials were eligible for inclusion if the intervention comprised of postnatal exercise for women
with LPP onset during pregnancy or within 3 months after delivery and the outcome measures included changes in
LPP. Selected articles were assessed using the PEDro Scale for methodological quality and findings were synthesised narratively as meta-analysis was found to be inappropriate due to heterogeneity among included studies.
Results: Four randomised controlled trials were included, involving 251 postnatal women. Three trials were rated as
of âgoodâ methodological quality. All trials, except one, were at low risk of bias. The trials included physical exercise
programs with varying components, differing modes of delivery, follow up times and outcome measures. Intervention
in one trial, involving physical therapy with specific stabilising exercises, proved to be effective in reducing LPP
intensity. An improvement in gluteal pain on the right side was reported in another trial and a significant difference in
pain frequency in another.
Conclusion: Our review indicates that only few randomised controlled trials have evaluated the effectiveness of
exercise on LPP among postnatal women. There is also a great amount of variability across existing trials in the
components of exercise programs, modes of delivery, follow up times and outcome measures. While there is some
evidence to indicate the effectiveness of exercise for relieving LPP, further good quality trials are needed to ascertain
the most effective elements of postnatal exercise programs suited for LPP treatment
Macroscopic transport by synthetic molecular machines
Nature uses molecular motors and machines in virtually every significant biological process, but demonstrating that simpler artificial structures operating through the same gross mechanisms can be interfaced withâand perform physical tasks inâthe macroscopic world represents a significant hurdle for molecular nanotechnology. Here we describe a wholly synthetic molecular system that converts an external energy source (light) into biased brownian motion to transport a macroscopic cargo and do measurable work. The millimetre-scale directional transport of a liquid on a surface is achieved by using the biased brownian motion of stimuli-responsive rotaxanes (âmolecular shuttlesâ) to expose or conceal fluoroalkane residues and thereby modify surface tension. The collective operation of a monolayer of the molecular shuttles is sufficient to power the movement of a microlitre droplet of diiodomethane up a twelve-degree incline.
PepShell : visualization of conformational proteomics data
Proteins are dynamic molecules; they undergo crucial conformational changes induced by post-translational modifications and by binding of cofactors or other molecules. The characterization of these conformational changes and their relation to protein function is a central goal of structural biology. Unfortunately, most conventional methods to obtain structural information do not provide information on protein dynamics. Therefore, mass spectrometry-based approaches, such as limited proteolysis, hydrogen-deuterium exchange, and stable-isotope labeling, are frequently used to characterize protein conformation and dynamics, yet the interpretation of these data can be cumbersome and time consuming. Here, we present PepShell, a tool that allows interactive data analysis of mass spectrometry-based conformational proteomics studies by visualization of the identified peptides both at the sequence and structure levels. Moreover, PepShell allows the comparison of experiments under different conditions, including different proteolysis times or binding of the protein to different substrates or inhibitors
Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder
<p>Abstract</p> <p>Background</p> <p>The MAOA uVNTR polymorphism has been documented to affect the MAOA gene at the transcriptional level and is associated with aggressive impulsive behaviors, depression associated with suicide (depressed suicide), and major depressive disorder (MDD). We hypothesized that the uVNTR polymorphism confers vulnerability to MDD, suicide or both. The aim of this study was to explore the association between the MAOA uVNTR and depressed suicide, using multiple controls.</p> <p>Methods</p> <p>Four different groups were included: 432 community controls, 385 patients with MDD who had not attempted suicide, 96 community subjects without mental disorders who had attempted suicide, and 109 patients with MDD who had attempted suicide. The MAOA uVNTR polymorphism was genotyped by a PCR technique. The symptom profiles and personal characteristics in each group were also compared.</p> <p>Results</p> <p>The MAOA 4R allele was more frequent in males with MDD than in male community controls (Ď<sup>2 </sup>= 4.182, p = 0.041). Logistic regression analysis showed that, among the depressed subjects, those younger in age, more neurotic or who smoked had an increased risk of suicide (β = -0.04, p = 0.002; β = 0.15, p = 0.017; β = 0.79, p = 0.031, respectively). Moreover, among those who had attempted suicide, those younger in age, with more paternal overprotection, and more somatic symptoms were more likely to be in the MDD group than in the community group (β = -0.11, p < 0.001; β = 0.15, p = 0.026; β = 1.11, p < 0.001). Structural equation modeling (SEM) showed that nongenetic factors, such as age, paternal overprotection, and somatic symptoms, were associated with MDD, whereas depressed suicide were associated with severity of depression, personality traits, age, marital status, and inversely associated with anxiety symptoms. However, depression did not affect suicidal behavior in the community group.</p> <p>Conclusion</p> <p>The MAOA 4R allele is associated with enhanced vulnerability to suicide in depressed males, but not in community subjects. The MAOA 4R allele affects vulnerability to suicide through the mediating factor of depressive symptoms. Further large-scale studies are needed to verify the psychopathology of the relationships among MAOA uVNTR polymorphism, symptom profiles, and suicidal behavior.</p
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