35,185 research outputs found
Exploratory investigation of sound pressure level in the wake of an oscillating airfoil in the vicinity of stall
Wind tunnel tests were performed on two oscillating two-dimensional lifting surfaces. The first of these models had an NACA 0012 airfoil section while the second simulated the classical flat plate. Both of these models had a mean angle of attack of 12 degrees while being oscillated in pitch about their midchord with a double amplitude of 6 degrees. Wake surveys of sound pressure level were made over a frequency range from 16 to 32 Hz and at various free stream velocities up to 100 ft/sec. The sound pressure level spectrum indicated significant peaks in sound intensity at the oscillation frequency and its first harmonic near the wake of both models. From a comparison of these data with that of a sound level meter, it is concluded that most of the sound intensity is contained within these peaks and no appreciable peaks occur at higher harmonics. It is concluded that within the wake the sound intensity is largely pseudosound while at one chord length outside the wake, it is largely true vortex sound. For both the airfoil and flat plate the peaks appear to be more strongly dependent upon the airspeed than on the oscillation frequency. Therefore reduced frequency does not appear to be a significant parameter in the generation of wake sound intensity
Electrostatic effects on funneled landscapes and structural diversity in denatured protein ensembles
The denatured state of proteins is heterogeneous and susceptible to general hydrophobic and electrostatic forces, but to what extent does the funneled nature of protein energy landscapes play a role in the unfolded ensemble? We simulate the denatured ensemble of cytochrome c using a series of models. The models pinpoint the efficacy of incorporating energetic funnels toward the native state in contrast with models having no native structure-seeking tendency. These models also contain varying strengths of electrostatic effects and hydrophobic collapse. The simulations based on these models are compared with experimental distributions for the distances between a fluorescent donor and the heme acceptor that were extracted from time-resolved fluorescence energy transfer experiments on cytochrome c. Comparing simulations to detailed experimental data on several labeling sites allows us to quantify the dominant forces in denatured protein ensembles
Active Carboxylic Acid-Terminated Alkanethiol Self-Assembled Monolayers on Gold Bead Electrodes for Immobilization of Cytochromes c
It is extremely difficult to immobilize cytochrome c (cyt c) on carboxylic acid-terminated alkanethiol self-assembled monolayers (HOOC-SAM) on gold bead electrodes prepared in a hydrogen flame. We found that simple pretreatment of a HOOC-SAM/gold bead electrode by potential cycling in buffer solution in the range ±300 mV prior to immobilization of the protein facilitated stable cyt c binding to HOOC-SAMs. The stability of cyt c on the HOOC-SAMs is independent of the topology of the gold surface
A new class of sum rules for products of Bessel functions
In this paper we derive a new class of sum rules for products of the Bessel
functions of first kind. Using standard algebraic manipulations we extend some
of the well known properties of . Some physical applications of the
results are also discussed. A comparison with the Newberger[J. Math. Phys.
\textbf{23} (1982) 1278] sum rules is performed on a typical example.Comment: Published in Journal of Mathematical Physics, 9 pages, no picture
Predicting criticality and dynamic range in complex networks: effects of topology
The collective dynamics of a network of coupled excitable systems in response
to an external stimulus depends on the topology of the connections in the
network. Here we develop a general theoretical approach to study the effects of
network topology on dynamic range, which quantifies the range of stimulus
intensities resulting in distinguishable network responses. We find that the
largest eigenvalue of the weighted network adjacency matrix governs the network
dynamic range. Specifically, a largest eigenvalue equal to one corresponds to a
critical regime with maximum dynamic range. We gain deeper insight on the
effects of network topology using a nonlinear analysis in terms of additional
spectral properties of the adjacency matrix. We find that homogeneous networks
can reach a higher dynamic range than those with heterogeneous topology. Our
analysis, confirmed by numerical simulations, generalizes previous studies in
terms of the largest eigenvalue of the adjacency matrix.Comment: 4 pages, 3 figure
Microscopic expressions for the thermodynamic temperature
We show that arbitrary phase space vector fields can be used to generate
phase functions whose ensemble averages give the thermodynamic temperature. We
describe conditions for the validity of these functions in periodic boundary
systems and the Molecular Dynamics (MD) ensemble, and test them with a
short-ranged potential MD simulation.Comment: 21 pages, 2 figures, Revtex. Submitted to Phys. Rev.
Synchronous vs Asynchronous Chain Motion in α-Synuclein Contact Dynamics
α-Synuclein (α-syn) is an intrinsically unstructured 140-residue neuronal protein of uncertain function that is implicated in the etiology of Parkinson’s disease. Tertiary contact formation rate constants in α-syn, determined from diffusion-limited electron-transfer kinetics measurements, are poorly approximated by simple random polymer theory. One source of the discrepancy between theory and experiment may be that interior-loop formation rates are not well approximated by end-to-end contact dynamics models. We have addressed this issue with Monte Carlo simulations to model asynchronous and synchronous motion of contacting sites in a random polymer. These simulations suggest that a dynamical drag effect may slow interior-loop formation rates by about a factor of 2 in comparison to end-to-end loops of comparable size. The additional deviations from random coil behavior in α-syn likely arise from clustering of hydrophobic residues in the disordered polypeptide
Universal power law in the orientational relaxation in thermotropic liquid crystals
We observe a surprisingly general power law decay at short to intermediate
times in orientational relaxation in a variety of model systems (both calamitic
and discotic, and also discrete) for thermotropic liquid crystals. As all these
systems transit across the isotropic-nematic phase boundary, two power law
relaxation regimes, separated by a plateau, emerge giving rise to a step-like
feature (well-known in glassy liquids) in the single-particle second-rank
orientational time correlation function. In contrast to its probable dynamical
origin in supercooled liquids, we show that the power law here can originate
from the thermodynamic fluctuations of the orientational order parameter,
driven by the rapid growth in the second-rank orientational correlation length.Comment: Submitted to Physical Review Letter
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