Evaluating unspecific oxidative stress parameters in the sera of patients with irritable bowel syndrome

Objective: Irritable bowel syndrome (IBS) is a common global condition characterized by abdominal pain and alterations in bowel habits not caused by other organic diseases and its etiopathogenesis has not been elucidated. In this study, we aimed to evaluate the oxidative stress parameters in patients with IBS. Materials and methods: Fifty patients diagnosed with IBS using the Rome III criteria and a control group of 50 healthy subjects were included in the study. Oxidative stress parameters including total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values were analyzed from all study subjects. Results: Compared to the controls; the TOS and OSI values were significantly higher, and the TAS value was significantly lower in IBS patients (p < 0.001 for all). Conclusions: In present study we demonstrated that oxidative stress increased and antioxidant capacity decreased in IBS, and antioxidants might be beneficial in the supportive treatment for IBS

Eosinophilic Gastroenteritis Associated with Rheumatoid Arthritis

WOS: 000299651800007Objectives: In this article we evaluated the relationship between rheumatoid arthritis and eosinophilic gastroenteritis. Patients and methods: A 71-year-old female patient with a diagnosis of rheumatoid artritis was admitted to our clinic with gastrointestinal symptoms and peripheral eosinophilia. We examined the patient via gastrointestinal endoscopy, ultrasonography, computed tomography, stool analysis, and biochemical analysis. Results: Gastrointestinal endoscopy revealed esophageal dysmotility, pangastritis, and duedonal erythema. Histopathologic examinations revealed subacute and chronic inflammation with dense eosinophilic infiltration. Stool analyses were negative for fat, parasites, and other pathogens. The results for ultrasonograpy and computed tomographies were normal. Conclusion: This brief report showed us the importance of conducting further analysis when a patient with rheumatoid arthritis presents with peripheral eosinophilia and gastrointestinal discomfort. It also represents the possible coexistence of rheumatoid arthritis and eosinophilic gastroenteritis without an apparent etiology

Some inflammatory cytokine levels, iron metabolism and oxidan stress markers in subjects with nonalcoholic steatohepatitis

Objectives: The relation between nonalcoholic steatohepatitis and iron metabolism is still controversial. Free fatty acids, iron, and other sources of oxidative stress probably result in cell damage, and necroinflammation mediated by various cytokines

Evaluation of sleeping energy expenditure using the SenseWear Armband in patients with overt and subclinical hypothyroidism

Purpose: The aim of the present study was to evaluate the average sleeping energy expenditure (EE) levels using the SenseWear Armband (SWA) in patients with overt and subclinical hypothyroidism. Methods: Sixty patients with hypothyroidism and 30 healthy individuals were recruited for the study. Hypothyroid patients were divided into two groups: group 1 (n = 30) consisted of patients with overt hypothyroidism and group 2 (n = 30) consisted of patients with subclinical hypothyroidism. Lastly, group 3 (n = 30) consisted of healthy subjects. The average EE and metabolic equivalent of task (MET) values during sleep of all the hypothyroid participants were analyzed at baseline and at the end of the study. Data were also obtained from the healthy subjects at baseline. Results: The average sleeping EE and METs values were not significantly different at baseline. Similarly, these values did not change significantly after achieving a euthyroid state via thyroid hormone replacement (both p > 0.05). Conclusions: Contrary to what has been previously reported , the average sleeping EE and METs values in all hypothyroid patients and healthy individuals were similar at baseline and did not change in the patients with overt and subclinical hypothyroidism after achievement of a euthyroid state

Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions

Background: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions. Materials and Methods: In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions. Results: Compared to baseline, twenty-fourth hour creatinine levels were significantly increased ( P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline ( P < 0.001 for all) and 24 th hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media. Conclusion: Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney