A Review on Anticancer Potential of Nitric Oxide

Nitrous oxide (NO) is a free radical gas which performs various physiological and pathological processes in body. NO is produced by different enzymatic pathways and plays role in homeostasis. Over past years, NO has emerged as a molecule of interest in many ailments including cancer. But its role in cancer is still controversy. It can display dose-dependant anticancer therapy on one hand and induce procancer properties on the other hand. But as compared to conventional treatments, NO proved better tumor cell resistance. This review mentions dichotomous nature of NO that may encourage future research assessing the role of NO in cancer prevention and treatment either as a single agent or in combination with other antineoplastic compounds

Research on digital and online resources of academic libraries from 1981 to 2020: A bibliometric analysis

Purpose/Rational - The study has exclusive purpose to find out the literature growth on “Digital and Online Resources of Academic Libraries” within a specific time span 1981 to 2020. Digital resources play an important role in the proliferation of quality research. Plenty of literature has been published on the topic from 1981 to 2020. Design/Methodology - The present study attempts to analyze the literature using the biliometric technique. Further, the Science Citation Index (SCI) database and Web of Science (Core Collection) has been utilized as a source to extract the available published documents. Furthermore, the investigation utilizes VOS viewer to show the outcomes making a representation picture of the published documents. Findings - The study findings show that the published documents on the topic are “electronic books” and that the articles written reached out better. The study exhibits that the English language has been used the most to write documents and 2011-2015 has been considered the when most articles published. United States is the top country for such publications while Bar Ilan (Israel) is the top publishing university, the highest number of articles has been produced by Huang YM and the most frequent keyword has been used as e-books. The highly cited article is published with the titled, “E-books or textbooks: Students prefer textbooks” with the citation of 249 in total number. Value/Originality - The study provides information in a broad way on digital and electronic resources, published literature through a bibliometric analysis

Study Culture among College Graduate Students in Electronic Era

Reading is the basic step for learners in education and it plays a key part in literacy and language gaining. It increases intellectual aptitude through giving new thoughts, notions and enhances vocabulary. This study attempts to examine students \u27reading behavior in the electronic age and the reason for the decline towards reading. The population of the study was based on graduates’ students of public sector colleges of Lahore vicinity. A well-structured questionnaire for the survey was used for data collection. A sample of 334 students of graduate program was sampled employing proportionate random sampling technique from public sector colleges (6 girls and 6 boys). The study findings show that 43.4 percent of the students prefer to spend time on electronic media and they were reluctant to read the books. Further, they were involved and preferred to use a cell phone as compared to study. Similarly, the student was also found that they were using Facebook as compared to reading habits. This study concluded that students had more exposure to electronic media and social networking sites as compared to study culture

Anti-mycotic potential of Trichoderma spp. and leaf biomass of Azadirachta indica against the charcoal rot pathogen, Macrophomina phaseolina (Tassi) Goid in cowpea

Abstract Macrophomina phaseolina (Tassi) Goid is a destructive pathogen of cowpea that causes serious charcoal rot disease with significant yield losses. Antifungal activity of three indigenous Ascomycetes viz., Trichoderma harzianum, T. viride, and T. hamatum, and two Meliaceae members, i.e., Melia azedarach L. and Azadirachta indica L. were assessed against the pathogen. Laboratory screening trials with cell-free culture filtrate showed the maximum reduction in growth of M. phaseolina with T. harzianum, followed by T. viride. Various concentrations (1–5%) of methanolic leaf extract of A. indica showed more reduction in fungal biomass than M. azedarach. Pot experiment was performed by T. harzianum, T. viride, and dry leaf biomass of A. indica against M. phaseolina. Results revealed that potted soil amended with T. harzianum in combination with 1–3% dry leaf biomass of A. indica held a significant potential to decrease disease incidence to 20–25% and improve plant growth attributes up to fourfolds over positive control inoculated with M. phaseolina only. Physiology of the host plant was altered due to the incorporation of various soil amendments resulting in reduced activities of antioxidant enzymes (catalase, peroxidase, polyphenol oxidase, and phenylalanine ammonia lyase). It was concluded that fungal antagonists and allelopathic chemicals would be an effective and eco-friendly means of managing the charcoal rot disease

An Efficient Algorithm to Enhance Nonoverlapping Coverage Area with Less Energy Consumption in WSN

Several chargeable sensor nodes are deployed randomly to cover the target points with an efficient heuristic approach for the mobility of sensor nodes in an area of interest (AoI). The heuristic approach generates the cover set that includes the targets for a prolonged time. The cover sets are the subset of the total sensor node area where each set is capable of representing all the targets. The functionality of the sensor nodes depends upon the network lifetime of the target points covering an AoI. The network lifetime would improve by reducing the consumption of battery power through heuristic process. The proposed heuristic process can do this by generating cover sets and selecting sensor nodes with the highest remaining battery power. These cover sets remove the redundant sensor node in an AoI that causes the overlapping issue and assign the maximum lifetime which is the minimum amount of battery power of the sensor node, participating in the cover set. The results show the improvement in the mobility of sensor nodes by coverage and attain maximum network lifetime as compared to the existing algorithms

Prevalence of diversified antibiotic resistant bacteria within sanitation related facilities of human populated workplaces in Abbottabad.

Antibiotics discovery was a significant breakthrough in the field of therapeutic medicines, but the over (mis)use of such antibiotics (in parallel) caused the increasing number of resistant bacterial species at an ever-higher rate. This study was thus devised to assess the multi-drug resistant bacteria present in sanitation-related facilities in human workplaces. In this regard, samples were collected from different gender, location, and source-based facilities, and subsequent antibiotic sensitivity testing was performed on isolated bacterial strains. Four classes of the most commonly used antibiotics i.e., β-lactam, Aminoglycosides, Macrolides, and Sulphonamides, were evaluated against the isolated bacteria. The antibiotic resistance profile of different (70) bacterial strains showed that the antibiotic resistance-based clusters also followed the grouping based on their isolation sources, mainly the gender. Twenty-three bacterial strains were further selected for their 16s rRNA gene based molecular identification and for phylogenetic analysis to evaluate the taxonomic evolution of antibiotic resistant bacteria (ARB). Moreover, the bacterial resistance to Sulphonamides and beta lactam was observed to be the most and to Aminoglycosides and macrolides as the least. Plasmid curing was also performed for multidrug resistant (MDR) bacterial strains, which significantly abolished the resistance potential of bacterial strains for different antibiotics. These curing results suggested that the antibiotic resistance determinants in these purified bacterial strains are present on respective plasmids. Altogether, the data suggested that the human workplaces are the hotspot for the prevalence of MDR bacteria and thus may serve as the source of horizontal gene transfer and further transmission to other environments