Investigation of modal shapes of the alignment-leveling table

This paper focuses on the assessment of modal forms of the alignment leveling table and their impact to the angle measurement accuracy of circular scales. It also addresses the impact of the experimental stand structure to the measurement of these scales. Even though the performed investigations are used to determine the precision of a specific angle measurement system, the findings do have a wider range of applications and can be used for the development of precision measurement instruments. Experimental and numerical investigations are used to illustrate the efficiency and effectiveness of the proposed alignment-leveling table

Regenerated soleus muscle shows reduced creatine kinase efflux after contractile activity in vitro

Date of Acceptance: 07/10/2014 Acknowledgements We are very grateful to Petras Jeneckas and Audrius Capskas for technical assistance. The study was supported by a grant (No. MIP-067/2012) from the Research Council of Lithuania.Peer reviewedPostprin

H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells

Funding: This work was supported, in whole or in part, by European Social Fund under the Global Grant measure Grant VP1-3.1-ŠMM-07-K-02-057 (to A.L.), European Foundation for the Study of Diabetes grant (to T.V.), NHS Grampian Endowment grant (to A.R. and S.R.G.), Kuwait Ministry of Health grant (to M.A.), Saudi Ministry of Higher Education grant (to Y.A.,) as well as Saltire scholarship, Wenner-Gren Foundation Postdoctoral Fellowship, Albert Renold Travel Fellowship and a Novo Nordisk Foundation Challenge Grant (to B.G.).Peer reviewedPublisher PD

Investigation of modal shapes of the alignment-leveling table

This paper focuses on the assessment of modal forms of the alignment leveling table and their impact to the angle measurement accuracy of circular scales. It also addresses the impact of the experimental stand structure to the measurement of these scales. Even though the performed investigations are used to determine the precision of a specific angle measurement system, the findings do have a wider range of applications and can be used for the development of precision measurement instruments. Experimental and numerical investigations are used to illustrate the efficiency and effectiveness of the proposed alignment-leveling table

Investigation of modal shapes of the alignment-leveling table

This paper focuses on the assessment of modal forms of the alignment leveling table and their impact to the angle measurement accuracy of circular scales. It also addresses the impact of the experimental stand structure to the measurement of these scales. Even though the performed investigations are used to determine the precision of a specific angle measurement system, the findings do have a wider range of applications and can be used for the development of precision measurement instruments. Experimental and numerical investigations are used to illustrate the efficiency and effectiveness of the proposed alignment-leveling table

Plasma microRNA levels differ between endurance and strength athletes

Aim: MicroRNAs (miRNAs) are stable in the circulation and are likely to function in inter-organ communication during a variety of metabolic responses that involve changes in gene expression, including exercise training. However, it is unknown whether differences in circulating-miRNA (c-miRNA) levels are characteristic of training modality. Methods: We investigated whether levels of candidate c-miRNAs differ between elite male athletes of two different training modalities (n = 10 per group) - endurance (END) and strength (STR) - and between these groups and untrained controls (CON; n = 10). Fasted, non-exercised, morning plasma samples were analysed for 14 c-miRNAs (miR-1, miR-16-2, miR-20a-1, miR-21, miR-93, miR-103a, miR-133a, miR-146a, miR-192, miR-206, miR-221, miR-222, miR-451, miR-499). Moreover, we investigated whether c-miRNA levels were associated with quantitative performance-related phenotypes within and between groups. Results: miR-222 was present at different levels in the three participant groups (p = 0.028) with the highest levels being observed in END and the lowest in STR. A number of other c-miRNAs were present at higher levels in END than in STR (relative to STR, ± 1 SEM; miR-222: 1.94 fold (1.73-2.18), p = 0.011; miR-21: 1.56 fold (1.39-1.74), p = 0.013; miR-146a: 1.50 fold (1.38-1.64), p = 0.019; miR-221: 1.51 fold (1.34-1.70), p = 0.026). Regression analyses revealed several associations between candidate c-miRNA levels and strength-related performance measures before and after adjustment for muscle or fat mass, but not following adjustment for group. Conclusion: Certain c-miRNAs (miR-222, miR-21, miR-146a and miR-221) differ between endurance- and resistance-trained athletes and thus have potential as useful biomarkers of exercise training and / or play a role in exercise mode-specific training adaptations. However, levels of these c-miRNAs are probably unrelated to muscle bulk or fat reserves

Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy

ACKNOWLEDGMENTS The authors gratefully acknowledge the Microscopy and Histology Core Facility for their support and assistance in this work. The work presented here was supported as follows. AL: Awards AR052879 and AR056280 from the National Institute of Arthritis, Musculoskeletal and Skin Diseases; award 249156 from the FP7-PEOPLE-2009-RG programme, award CGA/18/05 from the Chief Scientist Office, award 21/019 from the NHS Grampian Research Endowment. AL, GSB and LKH: award 204815/Z/16/Z from the Wellcome Trust. AIHC: The Providence Airway Centre, the St. Paul's Foundation and the Michael Smith Foundation for Health Research trainee award (RT-2021-1591). LKH: Biotechnology and Biological Sciences Research Council (BB/R01857X/1, BB/V016849/1). CO: Independent Research Fund Denmark (201930362460).Peer reviewedPublisher PD

Efflux of Creatine Kinase from Isolated Soleus Muscle Depends on Age, Sex and Type of Exercise in Mice

Elevated plasma creatine kinase (CK) activity is often used as an indicator of exercise-induced muscle damage. Our aim was to study effects of contraction type, sex and age on CK efflux from isolated skeletal muscles of mice. The soleus muscle (SOL) of adult (7.5-month old) female C57BL/6J mice was subjected to either 100 passive stretches, isometric contractions or eccentric contractions, and muscle CK efflux was assessed after two-hour incubation in vitro. SOL of young (3-month old) male and female mice was studied after 100 eccentric contractions. For adult females, muscle CK efflux was larger (p < 0.05) after eccentric contractions than after incubation without exercise (698 ± 344 vs. 268 ± 184 mU·h−1, respectively), but smaller (p < 0.05) than for young females after the same type of exercise (1069 ± 341 mU·h−1). Eccentric exercise-induced CK efflux was larger in muscles of young males compared to young females (2046 ± 317 vs 1069 ± 341 mU · h−1, respectively, p < 0.001). Our results show that eccentric contractions induce a significant increase in muscle CK efflux immediately after exercise. Isolated muscle resistance to exercise-induced CK efflux depends on age and sex of mice

Efflux of Creatine Kinase from Isolated Soleus Muscle Depends on Age, Sex and Type of Exercise in Mice

Acknowledgements This research was funded by a grant (No. MIP-067/2012) from the Research Council of Lithuania. We are thankful to Petras Jeneckas and Audrius Čapskas for their technical assistance.Peer reviewedPublisher PD

Myostatin dysfunction impairs force generation in extensor digitorum longus muscle and increases exercise-induced protein efflux from extensor digitorum longus and soleus muscles

ACKNOWLEDGEMENTS This study was funded by a grant (No. MIP-067/2012) from the Research Council of Lithuania. We are thankful to Petras Jeneckas, Audrius Capskas, and Indre Libnickiene for their technical assistance.Peer reviewedPostprin