Effects of early and chronic exposure to high temperatures on growth performance, carcass parameters and fatty acids of subcutaneous lipid of broilers

This study was conducted to assess the effects of early and chronic exposure of broilers at a scorching temperature on growth performance, carcass parameters, fatty acid deposition and composition of subcutaneous lipids (SCL). Three hundred male chicks (Hubbard origin) of a day are reared for 50 days. They are divided into three groups, each of cent chicks. The chronic thermal environments are applied from the 8th growing day: a neutral temperature (NT: 25 ± 2°C) for the first one, a moderate summer temperature (MT: 32 ± 2°C) for the second and hot temperature (HT: 37 ± 2°C) for the third. The results were summarized as follows: (1) from the 40th day, a decrease of 37 g/d of feed intake (FI) related to HT was observed; (2) a higher body weight (BW) of NT chickens was recorded from the 40th day; (3) regarding the early breeding, a higher daily weight gain (DWG) was recorded in HT chickens at the end of rearing; (4) compared to other temperature, the feed conversion ratio (FCR) of HT chickens was significantly better from 40th day; (5) at the end of breeding, the yields EC/BW: eviscerated carcass weight (EC) on body weight (BW) were comparable as recorded in NT and HT chickens; (6) at the end of breeding, a decreased weight of pectoral muscle (PM) associated with the HT was observed: -17 and - 20% compared with TM and TN, respectively; (7) a higher deposit of SCL up to 105g/Chicken and SCL/EC (+7.3% compared with NT) occur in the HT chickens mainly at the end of rearing; (8) conversely, the abdominal fat weight (AF) was higher in NT chickens from the 32th day; (9) compared with NT chickens, an increase in the proportion of saturated fatty acids (SFA) and polyunsaturated (PUFA) of SCL was obtained in HT chickens of 50 days. No temperature effect on the monounsaturated fatty acids proportion (MUFA) of LSC has been highlighted. Finally, the HT resulted in a significant decrease of the UFA/SFA ratio reflecting a degree of SCL saturation greater in HT chicken carcass; (10) these results have shown that chickens can tolerate early and chronic higher temperatures.Keys words: Temperature, broilers, growth, subcutaneous lipids, fatty acids

Service and Content Presentation in Ubiquitous Environments

The heterogeneous, dynamic nature of ubiquitous environments necessitates that all system components that form part of a personalisation framework should be context aware. Personalised service delivery requires that the system must detect and interpret device modality contexts in real time and provide automated adaptation on behalf of the user. Towards this aim, this paper presents the design and implementation of a demonstrator that offers personalised, context sensitive, service and content delivery

Ratio of carbon dioxide veno-arterial difference to oxygen arterial-venous difference is not associated with lactate decrease after fluid bolus in critically ill patients with hyperlactatemia: results from a prospective observational study

Background: High ratio of the carbon dioxide veno-arterial difference to the oxygen arterial-venous difference (PvaCO2/CavO2) is associated with fluid bolus (FB) induced increase in oxygen consumption (VO2). This study investigated whether PvaCO2/CavO2 was associated with decreases in blood-lactate levels FB in critically ill patients with hyperlactatemia. Methods: This prospective observational study examined adult patients in the intensive care unit (ICU) with lactate levels > 1.5 mmol/L who received FBs. Blood-lactate levels were measured before and after FB under unchanged metabolic, respiratory, and hemodynamic conditions. The primary outcome was blood-lactate levels after FB. Significant decreases in blood-lactate levels were considered as blood-lactate levels < 1.5 mmol/L or a decrease of more than 10% compared to baseline. Results: The study enrolled 40 critically ill patients, and their median concentration of blood lactate was 2.6 [IQR:1.9 − 3.8] mmol/L. There were 27 (68%) patients with PvaCO2/CavO2 ≥ 1.4 mmHg/ml, and 10 of them had an increase in oxygen consumption (dVO2) ≥ 15% after FB, while 13 (32%) patients had PvaCO2/CavO2 < 1.4 mmHg/ml before FB, and none of them had dVO2 ≥ 15% after FB. FB increased the cardiac index in patients with high and low preinfusion PvaCO2/CavO2 (13.4% [IQR: 8.3 − 20.2] vs. 8.8% [IQR: 2.9 − 17.4], p = 0.34). Baseline PvaCO2/CavO2 was not found to be associated with a decrease in blood lactate after FB (OR: 0.88 [95% CI: 0.39 − 1.98], p = 0.76). A positive correlation was observed between changes in blood lactate and baseline PvaCO2/CavO2 (r = 0.35, p = 0.02). Conclusions: In critically ill patients with hyperlactatemia, PvaCO2/CavO2 before FB cannot be used to predict decreases in blood-lactate levels after FB. Increased PvaCO2/CavO2 is associated with less decrease in blood-lactate levels

A lower global lung ultrasound score is associated with higher likelihood of successful extubation in invasively ventilated COVID-19 patients

Lung ultrasound (LUS) can be used to assess loss of aeration, which is associated with outcome in patients with coronavirus disease 2019 (COVID-19) presenting to the emergency department. We hypothesized that LUS scores are associated with outcome in critically ill COVID-19 patients receiving invasive ventilation. This retrospective international multicenter study evaluated patients with COVID-19-related acute respiratory distress syndrome (ARDS) with at least one LUS study within 5 days after invasive mechanical ventilation initiation. The global LUS score was calculated by summing the 12 regional scores (range 0-36). Pleural line abnormalities and subpleural consolidations were also scored. The outcomes were successful liberation from the ventilator and intensive care mortality within 28 days, analyzed with multistate, competing risk proportional hazard models. One hundred thirty-seven patients with COVID-19-related ARDS were included in our study. The global LUS score was associated with successful liberation from mechanical ventilation (hazard ratio [HR]: 0.91 95% confidence interval [CI] 0.87-0.96; P = 0.0007) independently of the ARDS severity, but not with 28 days mortality (HR: 1.03; 95% CI 0.97-1.08; P = 0.36). Subpleural consolidation and pleural line abnormalities did not add to the prognostic value of the global LUS score. Examinations within 24 hours of intubation showed no prognostic value. To conclude, a lower global LUS score 24 hours after invasive ventilation initiation is associated with increased probability of liberation from the mechanical ventilator COVID-19 ARDS patients, independently of the ARDS severity.Pathogenesis and treatment of chronic pulmonary disease

Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial

background acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. Identifying ARDS subphenotypes based on "focal" or "non-focal" lung morphology has the potential to better target mechanical ventilation strategies of individual patients. however, classifying morphology through chest radiography or computed tomography is either inaccurate or impractical. Lung ultrasound (LUS) is a non-invasive bedside tool that can accurately distinguish "focal" from "non-focal" lung morphology. We hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients leads to a reduction in 90-day mortality compared to conventional mechanical ventilation. methods the personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS) study is an investigator-initiated, international, randomized clinical trial (RCT) that plans to enroll 538 invasively ventilated adult intensive care unit (ICU) patients with moderate to severe ARDS. eligible patients will receive a LUS exam to classify lung morphology as "focal" or "non-focal". thereafter, patients will be randomized within 12 h after ARDS diagnosis to receive standard care or personalized ventilation where the ventilation strategy is adjusted to the morphology subphenotype, i.e., higher positive end-expiratory pressure (PEEP) and recruitment maneuvers for "non-focal" ARDS and lower PEEP and prone positioning for "focal" ARDS. the primary endpoint is all-cause mortality at day 90. secondary outcomes are mortality at day 28, ventilator-free days at day 28, ICU length of stay, ICU mortality, hospital length of stay, hospital mortality, and number of complications (ventilator-associated pneumonia, pneumothorax, and need for rescue therapy). after a pilot phase of 80 patients, the correct interpretation of LUS images and correct application of the intervention within the safe limits of mechanical ventilation will be evaluated. discussion PEGASUS is the first RCT that compares LUS-guided personalized mechanical ventilation with conventional ventilation in invasively ventilated patients with moderate and severe ARDS. If this study demonstrates that personalized ventilation guided by LUS can improve the outcomes of ARDS patients, it has the potential to shift the existing one-size-fits-all ventilation strategy towards a more individualized approach. trial registration the PEGASUS trial was registered before the inclusion of the first patient, https://clinicaltrials.gov/ (ID: NCT05492344)

Synthesis of 4-methylthiazol-2(3H)-thione derivatives and their application as corrosion inhibitors: weight loss, electrochemical, XPS and theoretical study

The corrosion inhibition of C38 steel in 1M HCl by isomeric derivatives of 4-methylthiazol-2(3H)-thione (TO1, TO4 and TO6) has been investigated using weight loss and electrochemical measurements supplementing with surface characterization study using X-ray photoelectron spectroscopy (XPS). Experimental observations were found to be in agreement with density functional theory (DFT) calculations. The inhibition efficiency increases with increase in the three compounds concentration and showed maximum inhibition efficiency of 98.33%, 96.91% and 94.44% for TO1, TO4 and TO6 at 2.10-4M in HCl 1M, respectively, at concentration of 2×10-4 M at 30°C. Polarization curves reveal that the three inhibitors act as mixed type inhibitor with tendency to anodic branch. Impedance parameters (charge transfer resistance, Rt, and double-layer capacitance, Cdl) indicate that the investigated compounds form stable protective films on the steel surface. Adsorption of TO1, TO4 and TO6 on the C38 steel surface is found to obey the Langmuir adsorption isotherm. The X-ray photoelectron spectroscopy (XPS) of the carbon steel treated with the three compounds indicated that these later are chemically adsorbed on the steel surface.  Good correlations were obtained between the anti-corrosion performance of these donor-acceptor compounds and their molecular properties

Peroperative cardiogenic shock suggesting acute coronary syndrome as initial manifestation of Lyme carditis.

Carditis can complicate Lyme disease in an estimated <5% of cases, and cardiogenic shock and severe cardiac arrhythmias are described with electrocardiographic abnormalities that could be suggestive of coronary manifestations. We report a case of severe persistent biventricular heart failure complicated by cardiac arrhythmias as initial manifestation of a Lyme disease developing peroperatively electrocardiographic abnormalities suggesting acute transmural myocardial infarction

Endommagement des composites tisses a matrice PMR-15 en fatigue oligocyclique isotherme

Communication to : 10 emes Journees nationales sur les composites 'JNC10', ENSAM - Paris (France), 29-31 octobre 1996Available at INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.1996 n.185 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc