Diafragma laserasyonu ve bronşektaziye yol açan bronşial web ile birlikteki kostal ekzositoz

Thoracic complications belong to exostosis with the other abnormality are extremely rare. A 40 year-old man presented with right-sided pleuritic chest pain. Computed tomographic scan of the chest revealed exostosis length 2.5 cm pushing pleura and diaphragm and compressing adjacent to lung and liver. Middle and lower lobe bronchiectasis was also identified. There were a web lesion in bronchial lumen at the level of middle lobe at bronchoscopy. In operation, diaphragm laceration was repaired with sutures. Bilobectomy inferior was performed and 10th costa was partially resected together with exostosis. Exostosis cases which lead to diaphragm laceration and bronchiectasis in addition with bronchial web as we present in this case are quite rare

The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer : A case control study

Proje -- Kırıkale Üniversitesi2007-110087299

Treatment of Iatrogenic tracheal laceration with cervical mediastinotomy and tube drainage; a case report

Trakeobronşiyal hasar endotrakeal entübasyonun hayati bir komplikasyonudur. Akciğer kist hidatiği nedeniyle standart torakotomi ile kistotomi ve kapitonaj ameliyatı uygulanan 7 yaşındaki bir kız çocukta masif ciltaltı amfizem gelişmesi sonrasında teşhis edilen, entübasyon nedenli trakea yaralanması sunuldu. Tedavide servikal mediastinotomi ve tüp drenajı başarıyla kullanıldı. Konservatif ve cerrahi tedavi metodları tartışıldı.Tracheobronchial injury is a life threatening complication of endotracheal intubation. An intubation induced tracheal laceration diagnosed aſter massive subcutaneous emphysema, in a 7-year-old girl who underwent a cystotomy and capitonnage operation through a standard thoracotomy for pulmonary hydatid cyst is presented. She was treated with cervical mediastinotomy and tube drainage with an uneventful clinical outcome. Conservative and surgical treatment methods are discussed

Giant arteriovenous malformation located on the chest wall - Diagnosis and endovascular treatment: Report of a case

Peynircioglu, Bora/0000-0002-1457-4721WOS: 000284645600012PubMed: 21110162Congenital arteriovenous malformations are usually found in the lower extremities, but a chest wall location is extremely rare. Extensive vascular malformations present difficulties for patients because of severe unsightliness and life-threatening bleeding. Surgical planning and therapeutic indications in vascular malformations are still a difficult problem. This report describes the case of a 27-year-old woman with a congenital giant arteriovenous malformation of the left chest wall. Preoperative embolization was planned prior to surgical intervention because of the increased risk of massive bleeding, and the malformation was completely embolized with absolute alcohol

Autologous Blood Pleurodesis in Rats to Elucidate the Amounts of Blood Required for Reliable and Reproducible Results

Ozpolat, Berkant/0000-0002-6203-7306; GAZYAGCI, SERKAL/0000-0002-0043-6942WOS: 000277885300009PubMed: 19524261Background. Pleurodesis is used in the treatment of spontaneous pneumothorax or refractory pleural effusions of different etiologies. Several agents have been employed, but many questions remain unanswered about their effectiveness and toxicity. Use of autologous blood pleurodesis in clinical practice has been described in the literature without any clear consensus regarding its efficacy. Experimental studies using this technique are limited to a single study in rabbits. We performed a prospective, randomized, observer-blinded, controlled study to evaluate the safety and efficacy of increasing doses of autologous blood pleurodesis in a novel rat model. Materials and Methods. Twenty-eight albino Wistar rats were divided into four groups. Groups 1, 2, and 3 were the study groups and group 4 was the control group, with seven animals in each group. Groups 1, 2, and 3 were given autologous blood, 1mL/kg, 2mL/kg, 3mL/kg, respectively, and group 4 (control) was given only 2mL/kg saline intrapleurally. The rats were sacrificed on postoperative day 30. The surfaces were graded by macroscopic (visible adhesion formation) and microscopic (inflammation and fibrosis) examination. Results. Macroscopically, group 2 and group 3 developed significantly more adhesions; 3mL/kg autologous blood produced the most significant pleurodesis with generalized adhesions seen between visceral, parietal, and mediastinal pleura. Microscopic examination showed that all study groups developed an inflammatory response at the site of blood injection. There were no pathologic changes in ipsilateral and contralateral lung parenchyma. Conclusions. Autologous blood at doses 2-3mL/kg were shown to be effective to produce adhesions in 30 d, and the results were highly reproducible in all rats. We propose that the occasional negative results obtained in humans may be related to an insufficient amount of injected blood, as observed in our rat model. (C) 2010 Elsevier Inc. All rights reserved

Management of gastrostomy to prevent perforation in acute severe corrosive esophagitis and gastritis: An experimental study

ATINKAYA, CANSEL/0000-0002-8583-3479WOS: 000292752300001PubMed: 21796545Background/aims: Symptomatic treatment is still the most commonly preferred treatment modality for acute severe esophagitis and gastritis. Clinical results of this treatment range from pathologies like stricture formation to loss of life. In our study, we aimed to demonstrate the effect of immediate gastrostomy in preventing perforation due to corrosive trauma. Methods: We used 32 rats in two study groups. In Group I (n: 16 rats), 1 ml of corrosive agent (10% NaOH solution) was administered and immediate gastrostomies were performed within 2 hours. In Group II (n: 16 rats), 1 ml corrosive agent (10% NaOH solution) was administered and the rats were treated symptomatically; no operation was performed. Results: Acute death was observed in 5 rats just after the corrosive agent was administered at the beginning of the study. Three rats from Group II died due to esophageal and gastric perforation within one week (25%). Necrosis was reported in 5 non-gastrostomized rats; however, no necrosis was observed in the gastrostomized group (p=0.037). Conclusions: Severe acute corrosive esophagitis and gastritis may be fatal. Furthermore, survivors may suffer from lifelong associated problems. From this study, we concluded that immediate gastrostomy in acute corrosive esophagitis and gastritis may play an important role in preventing necrosis and perforation risk

Cadaver analysis of thoracic outlet anomalies

Background: This study aims to determinate the rate of thoracic outlet anomalies by means of analysis of cadavers.Methods: Supraclavicular incisions were applied by two anatomists and two thoracic surgeons in the thoracocervicoaxillary region of both extremities (n=40) in twenty cadavers (7 females, 13 males; mean age 46). The formation and type of fibrous bands, cervical ribs, C7 long transverse processes and anomalies of the clavicles, scalenus anterior and scalenus medius muscles, brachial plexus, subclavian arteries and veins were evaluated. The type and formation of fibrous bands were classified using Roos' classification.Results: Anomalies were found in 34 (85%) of extremities. The type 3-band was most frequently (15%) observed and all of them were on the right extremity. The type 4-band was rarely seen (2.5%). Two bands (type 9 and type 11) in the same extremity were notified in one cadaver. (2.5%). The occurrence rate of cervical rib and C7 long transverse process was 10%. Some fibers of m. scalenus medius emerged from a cervical rib in one extremity (2.5%). The arteria subclavia anterior passed through the scalene muscle in three extremities (7.5%). In 10% of extremities the C5 truncus passing through the anterior scalene muscle and upper truncus of brachial plexus passing anterior scalene muscle via perforation was found in 7.5% of patients.Conclusion: In our population, brachial plexus and subclavian artery variations are frequently observed. Therefore these types of anomalies should be taken into consideration to prevent morbidity and complications when muscle division or blockage applications are performed

PLASMA ADA AND PON1-ARYLESTERASE ENZYME ACTIVITIES IN LUNG CANCER PATIENTS

GURBUZ, ASLIHAN/0000-0002-5089-3965WOS: 000264089500214

The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: A case-control study

ATINKAYA, CANSEL/0000-0002-8583-3479WOS: 000309712900010PubMed: 22893352Lung cancer, which is mainly affected by environmental factors, is a lethal malignancy. It is also important to investigate the effect of genetic factors on lung cancer aetiology. In this study, we aimed to investigate the distribution of CYP1A1*2C, GSTT1 and GSTM1 polymorphisms in Turkish lung cancer patients to determine whether any promoting effect of polymorphisms could cause development of lung cancer. For this purpose, genomic DNA samples obtained from peripheral blood of 128 patients with lung cancer and 122 healthy subjects were analyzed. Genotyping of polymorphic enzymes were carried out by polymerase chain reaction-restriction fragment length polymorphism methods. Although there were no significant differences between groups in terms of CYP1A1 polymorphism, the carriers of CYP1A1 Ile/Val genotype (odds ratio [OR] = 1.224, 95% confidence interval [CI]: 0.585-2.564) or CYP1A1 Val/Val genotype (OR = 3.058, 95% CI: 0.312-30.303) had an increased risk of lung cancer development. There was no statistical difference between groups in terms of both GSTT1 null genotype (OR = 1.114, 95% CI: 0.590-2.105) and GSTM1 null genotype (OR = 0.776, 95% CI: 0.466-1.290). This is the first case-control study investigating CYP1A1 Ile/Val, GSTT1 and GSTM1 polymorphisms in Turkish lung cancer patients. Although we suggest that other genes in addition to the proposed genes could play a role in lung cancer development, the results of our study will contribute to the possible associations between CYP1A1 Ile/Val, GSTT1 and GSTM1 gene polymorphism on the risk of lung cancer

PLASMA NITRIC OXIDE LEVELS AND NITRIC OXIDE SYNTHASE ACTIVITY IN LUNG CANCER PATIENTS

GURBUZ, ASLIHAN/0000-0002-5089-3965WOS: 000264089500345