The fickle Mutation of a Cytoplasmic Tyrosine Kinase Effects Sensitization but not Dishabituation in Drosophila Melanogaster

fickle is a P-element mutation identified from a screen for defects in courtship behavior and disrupts the fly homolog of Bruton's tyrosine kinase (Btk) gene (Baba et al., 1999). Here, we show that habituation of the olfactory jump reflex also is defective in fickle. Unlike, the prototypical memory mutants, rutabaga and dunce, which habituate more slowly than normal, fickle flies habituate faster than normal. fickle's faster-than-normal response decrement did not appear to be due to sensorimotor fatigue, and dishabituation of the jump response was normal. Based on a long-standing “two opponent process” theory of habituation, these data suggested that behavioral sensitization might be defective in fickle. To test this hypothesis, we designed a olfactory sensitization procedure, using the same stimuli to habituate (odor) and dishabituate (vortexing) flies. Mutant flies failed to show any sensitization with this procedure. Our study reveals a “genetic dissection” of sensitization and dishabituation and, for the first time, provides a biological confirmation of the two opponent process theory of habituation

A Search for Scalar Chameleons with ADMX

Scalar fields with a "chameleon" property, in which the effective particle mass is a function of its local environment, are common to many theories beyond the standard model and could be responsible for dark energy. If these fields couple weakly to the photon, they could be detectable through the "afterglow" effect of photon-chameleon-photon transitions. The ADMX experiment was used in the first chameleon search with a microwave cavity to set a new limit on scalar chameleon-photon coupling excluding values between 2*10^9 and 5*10^14 for effective chameleon masses between 1.9510 and 1.9525 micro-eV.Comment: 4 pages, 3 figure

A SQUID-based microwave cavity search for dark-matter axions

Axions in the micro eV mass range are a plausible cold dark matter candidate and may be detected by their conversion into microwave photons in a resonant cavity immersed in a static magnetic field. The first result from such an axion search using a superconducting first-stage amplifier (SQUID) is reported. The SQUID amplifier, replacing a conventional GaAs field-effect transistor amplifier, successfully reached axion-photon coupling sensitivity in the band set by present axion models and sets the stage for a definitive axion search utilizing near quantum-limited SQUID amplifiers.Comment: 4 pages, 5 figures, submitted to PR

Move of a large but delicate apparatus on a trailer with air-ride suspension

When valuable delicate goods are shipped by truck, attention must be paid to vibrations that may cause damage. We present a case study of moving an extremely delicate 6230-kg superconducting magnet, immersed in liquid nitrogen, from Livermore, CA to Seattle, WA showing the steps of fatigue analysis of the load, a test move, and acceleration monitoring of the final move to ensure a successful damage-free transport

Superdeformation in 198^{198}Po

The $^{174}$Yb($^{29}$Si,5n) reaction at 148 MeV with thin targets was used to populate high-angular momentum states in $^{198}$Po. Resulting $\gamma$ rays were observed with Gammasphere. A weakly-populated superdeformed band of 10 $\gamma$-ray transitions was found and has been assigned to $^{198}$Po. This is the first observation of a SD band in the $A \approx 190$ region in a nucleus with $Z > 83$. The ${\cal J}^{(2)}$ of the new band is very similar to those of the yrast SD bands in $^{194}$Hg and $^{196}$Pb. The intensity profile suggests that this band is populated through states close to where the SD band crosses the yrast line and the angular momentum at which the fission process dominates.Comment: 10 pages, revtex, 2 figs. available on request, submitted to Phys. Rev. C. (Rapid Communications

Distributed flow optimization and cascading effects in weighted complex networks

We investigate the effect of a specific edge weighting scheme $\sim (k_i k_j)^{\beta}$ on distributed flow efficiency and robustness to cascading failures in scale-free networks. In particular, we analyze a simple, yet fundamental distributed flow model: current flow in random resistor networks. By the tuning of control parameter $\beta$ and by considering two general cases of relative node processing capabilities as well as the effect of bandwidth, we show the dependence of transport efficiency upon the correlations between the topology and weights. By studying the severity of cascades for different control parameter $\beta$, we find that network resilience to cascading overloads and network throughput is optimal for the same value of $\beta$ over the range of node capacities and available bandwidth