366 research outputs found
Encapsulation of aqueous-core nanocapsules in PLLA multicompartments microparticles
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Computed tomography angiography for the interventional cardiologist
WOS:000339902400002In recent years, coronary CT angiography (CCTA) has become a widely adopted technique, not only due to its high diagnostic accuracy, but also to the fact that CCTA provides a comprehensive evaluation of the total (obstructive and non-obstructive) coronary atherosclerotic burden. More recently, this technique has become mature, with a large body of evidence addressing its prognostic validation. In addition, CT angiography has moved from the field of `imagers' and clinicians and entered the interventional cardiology arena, aiding in the planning of both coronary and structural heart interventions, being transcatheter aortic valve implantation one of its most successful examples. It is therefore of utmost importance that interventional cardiologists become familiar with image interpretation and up-to-date regarding several CTA features, taking advantage of this information in planning the procedure, ultimately leading to improvement in patient outcomes. On the other hand, the increasing use of CCTA as a gatekeeper for invasive coronary angiography is expected to lead to an increase in the ratio of interventional to diagnostic procedures and significant changes in the daily cath-lab routine. In a foreseeable future, cath-labs will probably offer an invasive procedure only to patients expected to undergo an intervention, perhaps becoming in this change true interventional-labs.publishersversionpublishe
MOEA/D with Uniformly Randomly Adaptive Weights
When working with decomposition-based algorithms, an appropriate set of
weights might improve quality of the final solution. A set of uniformly
distributed weights usually leads to well-distributed solutions on a Pareto
front. However, there are two main difficulties with this approach. Firstly, it
may fail depending on the problem geometry. Secondly, the population size
becomes not flexible as the number of objectives increases. In this paper, we
propose the MOEA/D with Uniformly Randomly Adaptive Weights (MOEA/DURAW) which
uses the Uniformly Randomly method as an approach to subproblems generation,
allowing a flexible population size even when working with many objective
problems. During the evolutionary process, MOEA/D-URAW adds and removes
subproblems as a function of the sparsity level of the population. Moreover,
instead of requiring assumptions about the Pareto front shape, our method
adapts its weights to the shape of the problem during the evolutionary process.
Experimental results using WFG41-48 problem classes, with different Pareto
front shapes, shows that the present method presents better or equal results in
77.5% of the problems evaluated from 2 to 6 objectives when compared with
state-of-the-art methods in the literature
High molecular weight polystyrene particles by cationic miniemulsion polymerization catalyzed by an iron-containing imidazolium-based ionic liquid
Cationic styrene polymerizations in aqueous media were conducted using the miniemulsion polymerization technique with the ionic liquid 1-N-butyl-3-N-methylimidazolium heptachloro diferrate (BMI.Fe2Cl7) as catalyst, hexadecyltrimethylammonium bromide (CTAB) as surfactant and hexadecane as costabilizer. The ionic liquid
was effective to initiate styrene miniemulsion polymerization at a BMI.Fe2Cl7:styrene molar ratios as low as 1:1000. Increasing the reaction temperature from 70 °C to 90 °C led to an increase in both, conversion and molecular weight. And polystyrene with much higher molecular weight (viscosity average molecular weights of up to 2231 kDa) than those usually obtained in cationic polymerizations was produced. Furthermore, while particle sizes remained almost constant around 150 nm during polymerizations, an almost linear increase of conversion with reaction time was observed. In addition, molecular weight increased steadily with conversion approaching the behavior of living cationic polymerization.
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Enzimatic polycondensation of 1,4-butanediol and diethyl succinate
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On the nature of the (de)coupling of the magnetostructural transition in ErSi
In this report, a successful thermodynamical model was employed to understand
the structural transition in ErSi, able to explain the decoupling of
the magnetic and structural transition. This was achieved by the DFT
calculations which were used to determine the energy differences at 0 K, using
a LSDA+U approximation. It was found that the M structure as the stable phase
at low temperatures as verified experimentally with a 0.262 eV.
Finally, it was achieved a variation of Seebeck coefficient ( 6 V)
at the structural transition which allow to conclude that the electronic
entropy variation is negligible in the transition.Comment: 17 pages, 3 figures, 1 tabl
LÃnguas e culturas nos discursos educativos: revisões da literatura no âmbito da educação plurilingue e intercultural
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Field dimension and skill level constrain team tactical behaviours in small-sided and conditioned games in football
This study analysed the influence of field dimension and players’ skill level on collective tactical behaviours during small-sided and conditioned games (SSCGs). Positioning and displacement data were collected using global positioning systems (15 Hz) during SSCGs (Gk+4 v. 4+Gk) played by two groups of participants (NLP- national-level and RLP-regional-level players) on different field dimensions (small: 36.8 × 23.8 m; intermediate: 47.3 × 30.6 and large: 57.8 × 37.4 m). Team tactical performance was assessed through established dynamic team variables (effective playing space, playing length per width ratio and team separateness) and nonlinear signal processing techniques (sample entropy of distances to nearest opponents and the teams’ centroids’ mutual information). Results showed that the effective playing space and team separateness increased significantly with pitch size regardless of participant skill level (P < 0.001, η2 = 0.78 and P < 0.001, η2 = 0.65, respectively). Playing length per width ratio increased with pitch size for the NLP but was maintained at a relatively constant level by RLP across treatments indicating different playing shapes. There was significantly more irregularity in distances to nearest opponents for the NLP in small (P = 0.003) and intermediate fields (P = 0.01). Findings suggest that tactical behaviours in SSCGs are constrained by field size and skill level, which need to be considered by coaches when designing training practices
Coronary computed tomography angiography-adapted Leaman score as a tool to noninvasively quantify total coronary atherosclerotic burden
To describe a coronary computed tomography angiography (CCTA)-adapted Leaman score (CT-LeSc) as a tool to quantify total coronary atherosclerotic burden with information regarding localization, type of plaque and degree of stenosis and to identify clinical predictors of a high coronary atherosclerotic burden as assessed by the CT-LeSc. Single center prospective registry including a total of 772 consecutive patients undergoing CCTA (Dual-source CT) from April 2011 to March 2012. For the purpose of this study, 581 stable patients referred for suspected coronary artery disease (CAD) without previous myocardial infarction or revascularization procedures were included. Pre-test CAD probability was determined using both the Diamond-Forrester extended CAD consortium method (DF-CAD consortium model) and the Morise score. Cardiovascular risk was assessed with the HeartScore. The cut-off for the 3rd tercile (CT-LeSc ≥8.3) was used to define a population with a high coronary atherosclerotic burden. The median CT-LeSc in this population (n = 581, 8,136 coronary segments evaluated; mean age 57.6 ± 11.1; 55.8 % males; 14.6 % with diabetes) was 2.2 (IQR 0-6.8). In patients with CAD (n = 341), the median CT-LeSc was 5.8 (IQR 3.2-9.6). Among patients with nonobstructive CAD, most were classified in the lowest terciles (T1, 43.0 %; T2, 36.1 %), but 20.9 % were in the highest tercile (T3). The majority of the patients with obstructive CAD were classified in T3 (78.2 %), but 21.8 % had a CT-LeSc in lower terciles (T1 or T2). The independent predictors of a high CT-LeSc were: Male sex (OR 1.73; 95 % CI 1.04-2.90) diabetes (OR 2.91; 95 % CI 1.61-5.23), hypertension (OR 2.54; 95 % CI 1.40-4.63), Morise score ≥16 (OR 1.97; 95 % CI 1.06-3.67) and HeartScore ≥5 (OR 2.42; 95 % CI 1.41-4.14). We described a cardiac CT adapted Leaman score as a tool to quantify total (obstructive and nonobstructive) coronary atherosclerotic burden, reflecting the comprehensive information about localization, degree of stenosis and type of plaque provided by CCTA. Male sex, hypertension, diabetes, a HeartScore ≥5 % and a Morise score ≥16 were associated with a high coronary atherosclerotic burden, as assessed by the CT-LeSc. About one fifth of the patients with nonobstructive CAD had a CT-LeSc in the highest tercile, and this could potentially lead to a reclass
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