Gravity from a fermionic condensate of a gauge theory

The most prominent realization of gravity as a gauge theory similar to the gauge theories of the standard model comes from enlarging the gauge group from the Lorentz group to the de Sitter group. To regain ordinary Einstein-Cartan gravity the symmetry must be broken, which can be accomplished by known quasi-dynamic mechanisms. Motivated by symmetry breaking models in particle physics and condensed matter systems, we propose that the symmetry can naturally be broken by a homogenous and isotropic fermionic condensate of ordinary spinors. We demonstrate that the condensate is compatible with the Einstein-Cartan equations and can be imposed in a fully de Sitter invariant manner. This lends support, and provides a physically realistic mechanism for understanding gravity as a gauge theory with a spontaneously broken local de Sitter symmetry.Comment: 16 page

The Immirzi Parameter as an Instanton Angle

The Barbero-Immirzi parameter is a one parameter quantization ambiguity underpinning the loop approach to quantum gravity that bears tantalizing similarities to the theta parameter of gauge theories such as Yang-Mills and QCD. Despite the apparent semblance, the Barbero-Immirzi field has resisted a direct topological interpretation along the same lines as the theta-parameter. Here we offer such an interpretation. Our approach begins from the perspective of Einstein-Cartan gravity as the symmetry broken phase of a de Sitter gauge theory. From this angle, just as in ordinary gauge theories, a theta-term emerges from the requirement that the vacuum is stable against quantum mechanical tunneling. The Immirzi parameter is then identified as a combination of Newton's constant, the cosmological constant, and the theta-parameter.Comment: 24 page

Enhanced Auditory Neuron Survival Following Cell-Based BDNF Treatment in the Deaf Guinea Pig

Exogenous neurotrophin delivery to the deaf cochlea can prevent deafness-induced auditory neuron degeneration, however, we have previously reported that these survival effects are rapidly lost if the treatment stops. In addition, there are concerns that current experimental techniques are not safe enough to be used clinically. Therefore, for such treatments to be clinically transferable, methods of neurotrophin treatment that are safe, biocompatible and can support long-term auditory neuron survival are necessary. Cell transplantation and gene transfer, combined with encapsulation technologies, have the potential to address these issues. This study investigated the survival-promoting effects of encapsulated BDNF over-expressing Schwann cells on auditory neurons in the deaf guinea pig. In comparison to control (empty) capsules, there was significantly greater auditory neuron survival following the cell-based BDNF treatment. Concurrent use of a cochlear implant is expected to result in even greater auditory neuron survival, and provide a clinically relevant method to support auditory neuron survival that may lead to improved speech perception and language outcomes for cochlear implant patients

Of Lies and Disclaimers - Contracting around Fraud under Texas Law.

The Texas Supreme Court has failed to provide a bright-line test in determining whether reliance disclaimers are enforceable. A reliance disclaimer is a provision in a contract that disclaims all extra-contractual representations and provides that the contracting parties are not relying on any such representations. By including a reliance disclaimer, a contracting party may be attempting to immunize itself from liability for false statements made during negotiations. Even if a contracting party’s misrepresentations or non-disclosures were made with fraudulent intent, Texas law gives contracting parties broad freedom to contract around misrepresentation claims. In Forest Oil Corp. v. McAllen, the Texas Supreme Court articulated that it is relevant for a court to consider: (1) if the terms of the contract were negotiated, rather than boiler-plate; (2) if the complaining party was represented by counsel; (3) if the parties dealt with each other in an arm’s length transaction; (4) if the parties were knowledgeable in business matters; and (5) if the release language was clear. The decisions from Texas case law suggest a party can effectively bar misrepresentation and non-disclosure claims by including several provisions in the contract. Examples of provisions to include in a contract to support a reliance disclaimer include, but not limited to, full disclosure provisions and no reliance on representation provisions. Furthermore, the contract’s recitals should detail the parties’ arm’s-length negotiations, describe the parties’ sophistication in business matters with respect to the contract’s subject matter, and identify the types of advisors assisting the parties in the contract’s negotiation and drafting. Finally, the provisions should be conspicuous and initialed by the parties. The suggested provisions are consistent with relevant Texas precedent and should be relevant in a court’s analysis of the enforceability of a reliance disclaimer

Of Lies and Disclaimers - Contracting around Fraud under Texas Law.

The Texas Supreme Court has failed to provide a bright-line test in determining whether reliance disclaimers are enforceable. A reliance disclaimer is a provision in a contract that disclaims all extra-contractual representations and provides that the contracting parties are not relying on any such representations. By including a reliance disclaimer, a contracting party may be attempting to immunize itself from liability for false statements made during negotiations. Even if a contracting party’s misrepresentations or non-disclosures were made with fraudulent intent, Texas law gives contracting parties broad freedom to contract around misrepresentation claims. In Forest Oil Corp. v. McAllen, the Texas Supreme Court articulated that it is relevant for a court to consider: (1) if the terms of the contract were negotiated, rather than boiler-plate; (2) if the complaining party was represented by counsel; (3) if the parties dealt with each other in an arm’s length transaction; (4) if the parties were knowledgeable in business matters; and (5) if the release language was clear. The decisions from Texas case law suggest a party can effectively bar misrepresentation and non-disclosure claims by including several provisions in the contract. Examples of provisions to include in a contract to support a reliance disclaimer include, but not limited to, full disclosure provisions and no reliance on representation provisions. Furthermore, the contract’s recitals should detail the parties’ arm’s-length negotiations, describe the parties’ sophistication in business matters with respect to the contract’s subject matter, and identify the types of advisors assisting the parties in the contract’s negotiation and drafting. Finally, the provisions should be conspicuous and initialed by the parties. The suggested provisions are consistent with relevant Texas precedent and should be relevant in a court’s analysis of the enforceability of a reliance disclaimer

Genome Diversification in Phylogenetic Lineages I and II of \u3ci\u3eListeria monocytogenes\u3c/i\u3e: Identification of Segments Unique to Lineage II Populations

Thirteen different serotypes of Listeria monocytogenes can be distinguished on the basis of variation in somatic and flagellar antigens. Although the known virulence genes are present in all serotypes, greater than 90% of human cases of listeriosis are caused by serotypes 1/2a, 1/2b, and 4b and nearly all outbreaks of food-borne listeriosis have been caused by serotype 4b strains. Phylogenetic analysis of these three common clinical serotypes places them into two different lineages, with serotypes 1/2b and 4b belonging to lineage I and 1/2a belonging to lineage II. To begin examining evolution of the genome in these serotypes, DNA microarray analysis was used to identify lineage-specific and serotype-specific differences in genome content. A set of 44 strains representing serotypes 1/2a, 1/2b, and 4b was probed with a shotgun DNA microarray constructed from the serotype 1/2a strain 10403s. Clones spanning 47 different genes in 16 different contiguous segments relative to the lineage II 1/2a genome were found to be absent in all lineage I strains tested (serotype 4b and 1/2b) and an additional nine were altered exclusively in 4b strains. Southern hybridization confirmed that conserved alterations were, in all but two loci, due to absence of the segments from the genome. Genes within these contiguous segments comprise five functional categories, including genes involved in synthesis of cell surface molecules and regulation of virulence gene expression. Phylogenetic reconstruction and examination of compositional bias in the regions of difference are consistent with a model in which the ancestor of the two lineages had the 1/2 somatic serotype and the regions absent in the lineage I genome arose by loss of ancestral sequences

Threshold effects in excited charmed baryon decays

Motivated by recent results on charmed baryons from CLEO and FOCUS, we reexamine the couplings of the orbitally excited charmed baryons. Due to its proximity to the [Sigma_c pi] threshold, the strong decays of the Lambda_c(2593) are sensitive to finite width effects. This distorts the shape of the invariant mass spectrum in Lambda_{c1}-> Lambda_c pi^+pi^- from a simple Breit-Wigner resonance, which has implications for the experimental extraction of the Lambda_c(2593) mass and couplings. We perform a fit to unpublished CLEO data which gives M(Lambda_c(2593)) - M(Lambda_c) = 305.6 +- 0.3 MeV and h2^2 = 0.24^{+0.23}_{-0.11}, with h2 the Lambda_{c1}-> Sigma_c pi strong coupling in the chiral Lagrangian. We also comment on the new orbitally excited states recently observed by CLEO.Comment: 9 pages, 3 figure

Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers

IntroductionElectrical stimulation offers a drug-free alternative for the treatment of many neurological conditions, such as chronic pain. However, it is not easy to selectively activate afferent or efferent fibers of mixed nerves, nor their functional subtypes. Optogenetics overcomes these issues by controlling activity selectively in genetically modified fibers, however the reliability of responses to light are poor compared to electrical stimulation and the high intensities of light required present considerable translational challenges. In this study we employed a combined protocol of optical and electrical stimulation to the sciatic nerve in an optogenetic mouse model to allow for better selectivity, efficiency, and safety to overcome fundamental limitations of electrical-only and optical-only stimulation.MethodsThe sciatic nerve was surgically exposed in anesthetized mice (n = 12) expressing the ChR2-H134R opsin via the parvalbumin promoter. A custom-made peripheral nerve cuff electrode and a 452 nm laser-coupled optical fiber were used to elicit neural activity utilizing optical-only, electrical-only, or combined stimulation. Activation thresholds for the individual and combined responses were measured.ResultsOptically evoked responses had a conduction velocity of 34.3 m/s, consistent with ChR2-H134R expression in proprioceptive and low-threshold mechanoreceptor (Aα/Aβ) fibers which was also confirmed via immunohistochemical methods. Combined stimulation, utilizing a 1 ms near-threshold light pulse followed by an electrical pulse 0.5 ms later, approximately halved the electrical threshold for activation (p = 0.006, n = 5) and resulted in a 5.5 dB increase in the Aα/Aβ hybrid response amplitude compared to the electrical-only response at equivalent electrical levels (p = 0.003, n = 6). As a result, there was a 3.25 dB increase in the therapeutic stimulation window between the Aα/Aβ fiber and myogenic thresholds (p = 0.008, n = 4).DiscussionThe results demonstrate that light can be used to prime the optogenetically modified neural population to reside near threshold, thereby selectively reducing the electrical threshold for neural activation in these fibers. This reduces the amount of light needed for activation for increased safety and reduces potential off-target effects by only stimulating the fibers of interest. Since Aα/Aβ fibers are potential targets for neuromodulation in chronic pain conditions, these findings could be used to develop effective strategies to selectively manipulate pain transmission pathways in the periphery

Increased Matrix Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema

Rationale: Though matrix metalloproteinases (MMPs) are critical in the pathogenesis of COPD, their utility as a disease biomarker remains uncertain. This study aimed to determine whether bronchoalveolar lavage (BALF) or plasma MMP measurements correlated with disease severity or functional decline in emphysema. Methods: Enzyme-linked immunosorbent assay and luminex assays measured MMP-1, -9, -12 and tissue inhibitor of matrix metalloproteinase-1 in the BALF and plasma of non-smokers, smokers with normal lung function and moderate-to-severe emphysema subjects. In the cohort of 101 emphysema subjects correlative analyses were done to determine if MMP or TIMP-1 levels were associated with key disease parameters or change in lung function over an 18-month time period. Main Results: Compared to non-smoking controls, MMP and TIMP-1 BALF levels were significantly elevated in the emphysema cohort. Though MMP-1 was elevated in both the normal smoker and emphysema groups, collagenase activity was only increased in the emphysema subjects. In contrast to BALF, plasma MMP-9 and TIMP-1 levels were actually decreased in the emphysema cohort compared to the control groups. Both in the BALF and plasma, MMP and TIMP-1 measurements in the emphysema subjects did not correlate with important disease parameters and were not predictive of subsequent functional decline. Conclusions: MMPs are altered in the BALF and plasma of emphysema; however, the changes in MMPs correlate poorly with parameters of disease intensity or progression. Though MMPs are pivotal in the pathogenesis of COPD, these findings suggest that measuring MMPs will have limited utility as a prognostic marker in this disease. © 2013 D'Armiento et al

Planet Sensitivity from Combined Ground- and Space-based Microlensing Observations

To move one step forward toward a Galactic distribution of planets, we present the first planet sensitivity analysis for microlensing events with simultaneous observations from space and the ground. We present this analysis for two such events, OGLE-2014-BLG-0939 and OGLE-2014-BLG-0124, which both show substantial planet sensitivity even though neither of them reached high magnification. This suggests that an ensemble of low to moderate magnification events can also yield significant planet sensitivity and therefore probability to detect planets. The implications of our results to the ongoing and future space-based microlensing experiments to measure the Galactic distribution of planets are discussed.Comment: 10 pages, 5 figures, 1 table; ApJ in pres