New estimation of the post little ice age relative sea level rise

The study area is located in NW Sardinia Island (Italy), Mediterranean Sea. Sardinia is considered stable since the late Pliocene with a negligible subsidence of about 0.01 mm/y. It is therefore normally used to reconstruct the Pleistocene and Holocene sea level curves. Our research focusses on the sea-facing city of Alghero that from 1353 to 1720 was under the Spanish government. During this time, the city was renovated and new buildings edified. Dimension stones were quarried all around Alghero both in the nearby inland and along the coast. Coastal quarries were considered the most suitable for both rock quality and the easiest way to transport the quarried material by boat. The quarried rocks are late Pleistocene dune and beach sandstones deposited from the 132 ka (Marine Isotopic Stage-MIS5) to about 65 ka (MIS4). Sandstones crop out from few cm to 3 m above the present sea level and underwent several consolidation processes related to loading and marine weathering. This latter favoured dissolution and circulation of calcium carbonate which cemented the rocks. It is reported that the Spanish were looking for these "marine" sandstones for their high geotechnical characteristics. Different rules were adopted through time for the size of the dimension stones and this has allowed us to establish a quarry exploitation chronology. For example, "40 x 60 x 20" cm was the size of the dimension stones used for the Alghero Cathedral dated at 1505-1593. Nowadays most of the coastal Spanish quarry floors are 30 centimetres below mean sea level (tidal range is 30 cm). Accordingly, we infer that relative sea level from 1830 AD (and of the Little Ice Age) rose in about 200 years to the present level at the rate of about 1.4 mm/y. Considering that relative sea level rise during the Medieval warm period was of 0.6 mm/y over a period of about 400 years, we may deduce that human influence was strong enough to lead to a relative sea-level rise faster and in shorter time

Large Time Behavior of Solutions to the Neumann Problem for a Quasilinear Second Order Degenerate Parabolic Equation in Domains with Noncompact Boundary

AbstractWe investigate the optimal rate of stabilization at large time of a solution to the Neumann problemut=∑i=1N∂∂xi(ai(x, t, ∇u))−b(x, t, u),inΩ×(0, T),T>0∑i=1Nai(x, t, ∇u)ni=0,on∂Ω×(0, T)u(x, 0)=u0(x)x∈Ω,u0(x)⩾0inΩ,where Ω⊂RN, N⩾2, is an unbounded domain with sufficiently smooth noncompact boundary ∂Ω satisfying certain isoperimetrical inequality and n=(ni) is the outward normal to ∂Ω

Compact and explicit physical model for lateral metal-oxide-semiconductor field-effect transistor with nanoelectromechanical system based resonant gate

We propose a simple analytical model of a metal-oxide-semiconductor field-effect transistor with a lateral resonant gate based on the coupled electromechanical equations, which are self-consistently solved in time. All charge densities according to the mechanical oscillations are evaluated. The only input parameters are the physical characteristics of the device. No extra mathematical parameters are used to fit the experimental results. Theoretical results are in good agreement with the experimental data in static and dynamic operation. Our model is comprehensive and may be suitable for any electromechanical device based on the field-effect transduction

Large-Scale Integration of Nanoelectromechanical Systems for Gas Sensing Applications

We have developed arrays of nanomechanical systems (NEMS) by large-scale integration, comprising thousands of individual nanoresonators with densities of up to 6 million NEMS per square centimeter. The individual NEMS devices are electrically coupled using a combined series-parallel configuration that is extremely robust with respect to lithographical defects and mechanical or electrostatic-discharge damage. Given the large number of connected nanoresonators, the arrays are able to handle extremely high input powers (>1 W per array, corresponding to <1 mW per nanoresonator) without excessive heating or deterioration of resonance response. We demonstrate the utility of integrated NEMS arrays as high-performance chemical vapor sensors, detecting a part-per-billion concentration of a chemical warfare simulant within only a 2 s exposure period

Piezoelectric nanoelectromechanical resonators based on aluminum nitride thin films

We demonstrate piezoelectrically actuated, electrically tunable nanomechanical resonators based on multilayers containing a 100-nm-thin aluminum nitride (AlN) layer. Efficient piezoelectric actuation of very high frequency fundamental flexural modes up to ~80 MHz is demonstrated at room temperature. Thermomechanical fluctuations of AlN cantilevers measured by optical interferometry enable calibration of the transduction responsivity and displacement sensitivities of the resonators. Measurements and analyses show that the 100 nm AlN layer employed has an excellent piezoelectric coefficient, d_(31)=2.4 pm/V. Doubly clamped AlN beams exhibit significant frequency tuning behavior with applied dc voltage

Microbial-derived pirite as evidence of early diagenetic processes on a Late Holocene shoreface deposits (Sulcis Iglesiente, West Sardinia, Italy)

Since Roman time, SW Sardinia was a mine district and its fluorishing industrial activity lasted few decades ago. Mine activity in the district resulted in enhanced amount of sediments transported by rivers to the coast and, one of the major concern is elucidating the mineralogical background before and after industrial activity along the present-day coasts. A 3-m long core was collected in the shoreface zone, at -13–m depth below sea level and ca. 500 m far from the coastal area located on the southern-western of Sardinia (west Mediterranean, Italy). A multidisciplinary approach was followed to study the core and two samples were collected for dating purpose. 14C analysis revealed a Late Holocene age comprises between 4320 ± 30 BP (base) and 1420 ± 30 yeas BP (close to the top). Preliminary sedimentological data show that the core is composed of medium-fine grained sand, with the presence of aligned pebbles and/or shells at the base of the strata. These strata can be interpreted as the results of major storms occurred in a shoreface setting. Pervasive early diagenetic processes and sub-oxic conditions are observed as well. The preliminary geochemical results can be summarized as follows: 1) residual metal sulphides are not detected; 2) Zn and Pb carbonates can be found in samples collected close to the beaches, 3) barite and other minerals are often concentrated in the fine fraction (<63 microns). Moreover, the microscopic analysis reveals the presence of secondary pyrite that is interpreted to be of microbial origin. Thus the microbial activity most likely plays a fundamental tool in the pervasive early digenesis of the studied core. Bacterial activity and its effect on biominerals processes and sedimentological features are actually under investigation

Reducing the Weight of Spinal Pain in Children and Adolescents

Spinal pain in adults is a significant burden, from an individual and societal perspective. According to epidemiologic data, spinal pain is commonly found in children and adolescents, where evidence emerging over the past decade has demonstrated that spinal pain in adults can, in many cases, be traced back to childhood or adolescence. Nevertheless, very little focus has been on how to best manage spinal pain in younger age groups. The purpose of this article is to put the focus on spinal pain in children and adolescents and highlight how and where these problems emerge and how they are commonly dealt with. We will draw on findings from the relevant literature from adults to highlight potential common pathways that can be used in the management of spinal pain in children and adolescents. The overall focus is on how healthcare professionals can best support children and adolescents and their caregivers in making sense of spinal pain (when present) and support them in the self-management of the condition

Enzyme replacement therapy with agalsidase beta improves cardiac involvement in Fabry's disease.

Fabry's disease is an X-linked lysosomal storage disease caused by a deficiency of alpha-galactosidase that results in an accumulation of neutral glycosphingolipids throughout the body, including the cardiovascular system. Fabry cardiomyopathy, characterized by progressive severe concentric left ventricular (LV) hypertrophy, is very frequent and is the most important cause of death in affected patients. Enzyme replacement therapy (ERT) allows a specific treatment for this disease, however, there are very few data on the effectiveness of therapy on cardiac involvement. Nine patients with Fabry cardiac disease were studied on basal condition and after 6 and 12 months of treatment with algasidase beta (Fabrazyme). A complete clinical, electrocardiographic and echocardiographic evaluation was performed in all patients. Interpretable Doppler recordings of transmitral flow and pulmonary flow velocity curves were also acquired. At baseline, the patients with Fabry's disease had increased LV septum and posterior wall thickness, normal LV fractional shortening, LV ejection fraction, normal Doppler parameters of mitral inflow but a duration of pulmonary vein flow velocity wave exceeding that of the mitral wave at atrial systole. ERT did not affect heart rate and arterial pressure. LV internal diameters did not change, there was a slight but not significant decrease in the LV posterior wall thickening and a progressive decrease in the interventricular septum thickening (p < 0.025) and in LV mass (p < 0.001) The difference in duration between pulmonary vein flow velocity wave and mitral wave at atrial systole significantly decreased (p < 0.001). These results suggest that ERT in patients with Fabry cardiomyopathy is able to reduce the LV mass and ameliorate the LV stiffness