A Woman Idea in Cioran

Este artículo, de carácter interpretativo, lleva a cabo una reflexión acerca de la idea y el puesto de la mujer en la obra de Cioran desde una perspectiva no sólo femenina sino desde la situación cultural particular de su autora. Partiendo de varios de los textos del escritor rumano-francés, se analiza el tema mujer en dos ámbitos bien determinados por Cioran: primero, el de la prostitución y su parentesco con la filosofía y, segundo, el del ámbito de los santos.This interpretative article, performs a reflection about the idea and the position of women in the work of Cioran not only from a female perspective but from the particular cultural situation of the author of this paper. Starting from several texts from the Romanian-French writer, women’s issues is analyzed into two areas determined by Cioran: the first-one, prostitution and its relationship to philosophy and, the secondone from their reflexions about saint

Persistent Vascular Collagen Accumulation Alters Hemodynamic Recovery from Chronic Hypoxia

Pulmonary arterial hypertension (PAH) is caused by narrowing and stiffening of the pulmonary arteries that increase pulmonary vascular impedance (PVZ). In particular, small arteries narrow and large arteries stiffen. Large pulmonary artery (PA) stiffness is the best current predictor of mortality from PAH. We have previously shown that collagen accumulation leads to extralobar PA stiffening at high strain (Ooi et al. 2010). We hypothesized that collagen accumulation would increase PVZ, including total pulmonary vascular resistance (Z0), characteristic impedance (ZC), pulse wave velocity (PWV) and index of global wave reflections (Pb/Pf), which contribute to increased right ventricular afterload. We tested this hypothesis by exposing mice unable to degrade type I collagen (Col1a1R/R) to 21 days of hypoxia (hypoxia), some of which were allowed to recover for 42 days (recovery). Littermate wild-type mice (Col1a1+/+) were used as controls. In response to hypoxia, mean PA pressure (mPAP) increased in both mouse genotypes with no changes in cardiac output (CO) or PA inner diameter (ID); as a consequence, Z0 (mPAP/CO) increased by ∼100% in both genotypes (pZC, PWV and Pb/Pf did not change. However, with recovery, ZC and PWV decreased in the Col1a1+/+ mice and remained unchanged in the Col1a1R/R mice. Z0 decreased with recovery in both genotypes. Microcomputed tomography measurements of large PAs did not show evidence of stiffness changes as a function of hypoxia exposure or genotype. We conclude that hypoxia-induced PA collagen accumulation does not affect the pulsatile components of pulmonary hemodynamics but that excessive collagen accumulation does prevent normal hemodynamic recovery, which may have important consequences for right ventricular function

Structure-Force Field Generator for Molecular Dynamics Simulations

Atomistic and molecular simulations have become an important research field due to the progress made in computer performance and the necessity of new and improved materials. Despite this, first principle simulations of large molecules are still not possible because the high computational time and resources required. Other methods, such as molecular dynamics, allow the simplification of calculations by defining energy terms to describe multiple atom interactions without compromising accuracy significantly. A group of these energy terms is called a force field, and each force field has its own descriptions and parameters. The objective of this project was to develop a nanoHUB tool that allowed the calculation of all the force field parameters required to perform molecular dynamics simulations in polymers and molecular systems using a widely used software called Large scale Atomic/Molecular Massively Parallel Simulator (LAMMPS). The tool is written in Python 2.7 using OpenBabel and LAMMPS libraries, and it is currently implemented for generating DREIDING parameters and atomic charges with two methods: Gasteiger and Qeq. The LAMMPS Structure Generator takes an input file containing the atom positions in any system and format supported by OpenBabel and outputs a file with all the additional parameters required to run a simulation in LAMMPS using DREIDING force field. This software allows any researcher to run a simulation of polymers or molecules with an input file created immediately and for free

Pathways to Economic Outcomes and the Impact of Health: Comparing Hispanic and Non-Hispanic Adults after Foster Care

Abstract This study examines the financial outcomes in adulthood of Hispanics (N = 87) and White (Non-Hispanic, N = 498) persons placed in foster care during childhood. It uses the Casey Family Programs National Alumni Study (CFPNAS) database. Path models including predictors such as gender, education, having a partner, preparation for leaving care, and problem characteristics yielded predominantly similar effects for Hispanic and White Non-Hispanic respondents. The direct effect of physical and mental health conditions such as physical or learning disability, visual or hearing impairments, or DSM disorders more strongly predicted negative outcomes for White (Non-Hispanic) respondents than for Hispanic ones

Kernel Spectral Clustering and applications

In this chapter we review the main literature related to kernel spectral clustering (KSC), an approach to clustering cast within a kernel-based optimization setting. KSC represents a least-squares support vector machine based formulation of spectral clustering described by a weighted kernel PCA objective. Just as in the classifier case, the binary clustering model is expressed by a hyperplane in a high dimensional space induced by a kernel. In addition, the multi-way clustering can be obtained by combining a set of binary decision functions via an Error Correcting Output Codes (ECOC) encoding scheme. Because of its model-based nature, the KSC method encompasses three main steps: training, validation, testing. In the validation stage model selection is performed to obtain tuning parameters, like the number of clusters present in the data. This is a major advantage compared to classical spectral clustering where the determination of the clustering parameters is unclear and relies on heuristics. Once a KSC model is trained on a small subset of the entire data, it is able to generalize well to unseen test points. Beyond the basic formulation, sparse KSC algorithms based on the Incomplete Cholesky Decomposition (ICD) and $L_0$, $L_1, L_0 + L_1$, Group Lasso regularization are reviewed. In that respect, we show how it is possible to handle large scale data. Also, two possible ways to perform hierarchical clustering and a soft clustering method are presented. Finally, real-world applications such as image segmentation, power load time-series clustering, document clustering and big data learning are considered.Comment: chapter contribution to the book "Unsupervised Learning Algorithms

Testing common knowledge: are Northern Europeans and millennials more concerned about the environment?

This study explores whether there are differences in several environmental dimensions, when the European Region and Generation cohort are considered. In doing so, this study compares millennials in North and South Europe with members of Generation X in three environmental dimensions: attitudes, personal norms, and behavior. Using data from the European Social Survey (n = 6.216), the researchers tested the hypothesis that Northern Europeans and millennials have more pro-environmental standing than southerners and Generation Xers. The findings challenge the common belief that millennials are more committed to being environmentally conscious, showing that many millennials do not feel responsible for their climate footprint, nor do they behave in a way that shows more concern than previous generations to improve their environmental performance. Furthermore, contrary to expectations, Northern European participants are not the most committed, in all environmental dimensions, compared to Southern Europeans.info:eu-repo/semantics/publishedVersio

Leishmanicidal and cytotoxic activity of extracts and saponins from Ilex laurina (Aquifoliaceae)

Purpose: To evaluate the leishmanicidal and cytotoxic activity of alcohol and non-alcohol extracts and saponins from Ilex laurina.Methods: Extracts were obtained by percolation with solvents of different polarities: hexane, dichloromethane, ethyl acetate and ethanol. The ethyl acetate extract was subjected to silica gel column chromatography eluting with a step gradient of dichloromethane-methanol. All products were evaluated in vitro for leishmanicidal activity against amastigotes of leishmania panamensis and cytotoxicity on U-937 cells.Results: Two saponins were isolated from the ethyl acetate extract. The ethyl acetate extract showed high leishmanicidal activity against intracellular amastigotes of L. panamensis (EC50, 7.5 ± 1.5 μg/mL) and low activity against axenic amastigotes (EC50, 52.8 ±1.6 μg/mL); this extract showed also high cytotoxicity (LC50, 57.7 ± 12.1 μg/mL). Saponin 2 exhibited high activity against intracellular amastigotes (EC50, 5.9 ± 0.5 μg/mL) but also showed high cytotoxicity on U-937 cells (EC50, 25.7 ± 6.1 μg/mL). This compound showed similar leishmanicidal activity and cytotoxicity to meglumine antimoniate and amphotericin B, respectively, drugs currently used for the treatment of leishmaniasis.Conclusions: Based on these results, Ilex laurina is a potential source of compounds that can lead to the development of new therapeutic alternatives against leishmaniasis.Keywords: Leishmaniasis, Antiprotozoal, Saponin, Ilex laurina, Aquifoliacea