Evidence based practice in radiology: the radiographer perspective

This study is included in the exploratory-descriptive type, since it aims to analyze the applicability of knowledge and evidence based radiology by radiographers during their daily work and their academic education

A Layered Model for AI Governance

AI-based systems are “black boxes,” resulting in massive information asymmetries between the developers of such systems and consumers and policymakers. In order to bridge this information gap, this article proposes a conceptual framework for thinking about governance for AI

Balanced scorecard performance assessment in a medical imaging department

The authors present and discuss the development of a strategic management model based on the Balanced Scorecard by Kaplan and Norton to implement in an imaging ward and the relations with Performance Measurement System that allows for the monitoring of the service's evolution, the alignment of objectives, and the evaluation of individual employees within the strategy of the ward and the hospital

Scrap production of extruded aluminum alloys by direct extrusion

The growing globalization of the different types of market requires that companies invest, in a recurrent way, to optimize and improve all the processes inherent to their activities. Aluminium extrusion is the main industrial process used to create profiles of a fixed cross-section. This process requires appropriate processing parameters to be used, in order to produce diverse profiles and high-quality products. The company’s ability to adapt and improve the productive process are differentiating factors against the competition. Thus, understand the main operations and dynamics of the companies is crucial. This work presents an empirical study concerning the extrusion process of a Portuguese company in the aluminium sector. By analysing a real data base provided by the company, the main objective is to model the aluminium extrusion process. Taking into account the variables that most influence the extrusion of different profiles, the aim is to minimize the production of scrap. First, by studying the literature in the subject, the variables that most contribute to scrap production were identified. Since the database provided by the company did not present all the variables described in literature, proxy variables were considered. Next, a multivariate linear regression model for explaining the amount of scrap taking as explanatory the identified variables was estimated. With this analysis, it was possible to identify levels of significance of the variables under study, and therefore understand how each of the variables contributes to the increase or decrease of the amount of scrap on the production of aluminium profiles. The results show that variables concerning with extrusion temperature, time, speed, pressure and die geometry are crucial to improve and control the scrap production. The obtained model will be improved, in future work, by including further variables of the extrusion process. Furthermore, factor analysis and GHML methodologies will also be considered for explaining the production of scrap and therefore improve the production process.info:eu-repo/semantics/publishedVersio

Coexistence of glassy antiferromagnetism and giant magnetoresistance (GMR) in Fe/Cr multilayer structures

Using temperature-dependent magnetoresistance and magnetization measurements on Fe/Cr multilayers that exhibit pronounced giant magnetoresistance (GMR), we have found evidence for the presence of a glassy antiferromagnetic (GAF) phase. This phase reflects the influence of interlayer exchange coupling (IEC) at low temperature (T < 140K) and is characterized by a field-independent glassy transition temperature, Tg, together with irreversible behavior having logarithmic time dependence below a "de Almeida and Thouless" (AT) critical field line. At room temperature, where the GMR effect is still robust, IEC plays only a minor role, and it is the random potential variations acting on the magnetic domains that are responsible for the antiparallel interlayer domain alignment.Comment: 5 pages, 4 figure

Activity of daptomycin- and vancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms.

The aim of the present study was to develop novel daptomycin-loaded poly-epsilon-caprolactone (PCL) microparticles with enhanced antibiofilm activity against mature biofilms of clinically relevant bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and polysaccharide intercellular adhesin-positive Staphylococcus epidermidis. Daptomycin was encapsulated into PCL microparticles by a double emulsion-solvent evaporation method. For comparison purposes, formulations containing vancomycin were also prepared. Particle morphology, size distribution, encapsulation efficiency, surface charge, thermal behavior, and in vitro release were assessed. All formulations exhibited a spherical morphology, micrometer size, and negative surface charge. From a very early time stage, the released concentrations of daptomycin and vancomycin were higher than the minimal inhibitory concentration and continued so up to 72 hours. Daptomycin presented a sustained release profile with increasing concentrations of the drug being released up to 72 hours, whereas the release of vancomycin stabilized at 24 hours. The antibacterial activity of the microparticles was assessed by isothermal microcalorimetry against planktonic and sessile MRSA and S. epidermidis. Regarding planktonic bacteria, daptomycin-loaded PCL microparticles presented the highest antibacterial activity against both strains. Isothermal microcalorimetry also revealed that lower concentrations of daptomycin-loaded microparticles were required to completely inhibit the recovery of mature MRSA and S. epidermidis biofilms. Further characterization of the effect of daptomycin-loaded PCL microparticles on mature biofilms was performed by fluorescence in situ hybridization. Fluorescence in situ hybridization showed an important reduction in MRSA biofilm, whereas S. epidermidis biofilms, although inhibited, were not eradicated. In addition, an important attachment of the microparticles to MRSA and S. epidermidis biofilms was observed. Finally, all formulations proved to be biocompatible with both ISO compliant L929 fibroblasts and human MG63 osteoblast-like cells

Comparative photodynamic inactivation of bioluminescent E. coli by pyridinium and inverted pyridinium chlorins

Photodynamic inactivation (PDI) is a therapeutic approach in study due to the ability to reduce or completely eliminate the bacterial strains without the development of resistance mechanisms. In this therapeutic methodology the cationic chlorins (Chls) with pyridinium or inverted pyridinium moieties are one of the photosensitizers exploited in our biological approaches. In this context, we synthesized and characterized new free-base and zinc(II) complexes of pyridinium or inverted pyridinium Chl derivatives (1b, 2, 2a and 2b, respectively) for the inactivation of Escherichia coli (E. coli). The PDI assay was performed with white light irradiation delivered at a fluence rate of 25 mW cm−2. The obtained results of this study demonstrate high PDI efficiency of the zinc(II) metallated Chl 1b, reaching the detection limit of the bioluminescent method (5.2 log reduction) in 45 min of irradiation.publishe