Second coefficient of viscosity in air

Acoustic attenuation measurements in air were analyzed in order to estimate the second coefficient of viscosity. Data over a temperature range of 11 C to 50 C and at relative humidities between 6 percent and 91 percent were used. This analysis showed that the second coefficient of viscosity varied between 1900 and 20,000 times larger than the dynamic or first coefficient of viscosity over the temperature and humidity range of the data. In addition, the data showed that the molecular relaxation effects, which are responsible for the magnitude of the second coefficient of viscosity, place severe limits on the use of time-independent, thermodynamic equations of state. Compressible flows containing large streamwise velocity gradients, like shock waves, which cause significant changes in particle properties to occur during time intervals shorter than hundredths of seconds, must be modeled using dynamic equations of state. The dynamic model approach is described briefly

Landau damping of Bogoliubov excitations in optical lattices at finite temperature

We study the damping of Bogoliubov excitations in an optical lattice at finite temperatures. For simplicity, we consider a Bose-Hubbard tight-binding model and limit our analysis to the lowest excitation band. We use the Popov approximation to calculate the temperature dependence of the number of condensate atoms $n^{\rm c 0}(T)$ in each lattice well. We calculate the Landau damping of a Bogoliubov excitation in an optical lattice due to coupling to a thermal cloud of excitations. While most of the paper concentrates on 1D optical lattices, we also briefly present results for 2D and 3D lattices. For energy conservation to be satisfied, we find that the excitations in the collision process must exhibit anomalous dispersion ({\it i.e.} the excitation energy must bend upward at low momentum), as also exhibited by phonons in superfluid $^4\rm{He}$. This leads to the sudden disappearance of all damping processes in $D$-dimensional simple cubic optical lattice when $U n^{\rm c 0}\ge 6DJ$, where $U$ is the on-site interaction, and $J$ is the hopping matrix element. Beliaev damping in a 1D optical lattice is briefly discussed.Comment: 28 pages, 9 figure

IVOA Recommendation: SAMP - Simple Application Messaging Protocol Version 1.3

SAMP is a messaging protocol that enables astronomy software tools to interoperate and communicate. IVOA members have recognised that building a monolithic tool that attempts to fulfil all the requirements of all users is impractical, and it is a better use of our limited resources to enable individual tools to work together better. One element of this is defining common file formats for the exchange of data between different applications. Another important component is a messaging system that enables the applications to share data and take advantage of each other's functionality. SAMP builds on the success of a prior messaging protocol, PLASTIC, which has been in use since 2006 in over a dozen astronomy applications and has proven popular with users and developers. It is also intended to form a framework for more general messaging requirements

Structure and Evolution of Giant Cells in Global Models of Solar Convection

The global scales of solar convection are studied through three-dimensional simulations of compressible convection carried out in spherical shells of rotating fluid which extend from the base of the convection zone to within 15 Mm of the photosphere. Such modelling at the highest spatial resolution to date allows study of distinctly turbulent convection, revealing that coherent downflow structures associated with giant cells continue to play a significant role in maintaining the strong differential rotation that is achieved. These giant cells at lower latitudes exhibit prograde propagation relative to the mean zonal flow, or differential rotation, that they establish, and retrograde propagation of more isotropic structures with vortical character at mid and high latitudes. The interstices of the downflow networks often possess strong and compact cyclonic flows. The evolving giant-cell downflow systems can be partly masked by the intense smaller scales of convection driven closer to the surface, yet they are likely to be detectable with the helioseismic probing that is now becoming available. Indeed, the meandering streams and varying cellular subsurface flows revealed by helioseismology must be sampling contributions from the giant cells, yet it is difficult to separate out these signals from those attributed to the faster horizontal flows of supergranulation. To aid in such detection, we use our simulations to describe how the properties of giant cells may be expected to vary with depth, how their patterns evolve in time, and analyze the statistical features of correlations within these complex flow fields.Comment: 22 pages, 16 figures (color figures are low res), uses emulateapj.cls Latex class file, Results shown during a Press release at the AAS meeting in June 2007. Submitted to Ap

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma.

Our expanding knowledge of immunotherapy for solid tumors has led to an explosion of clinical trials aimed at urothelial carcinoma. The primary strategy is centered on unleashing the immune system by releasing the inhibitory signals propagated by programmed cell death-1 (PD-1) and its ligand programmed cell death ligand-1 (PD-L1). Many antibody constructs have been developed to block these interactions and are used in clinical trials. The Food and Drug Administration has already approved a number of checkpoint inhibitors such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) monoclonal antibodies including ipilimumab; anti-PD-1 monoclonal antibodies including nivolumab and pembrolizumab; anti-PD-L1 antibodies including atezolizumab, avelumab, and durvalumab. One of the latest inhibitors is durvalumab, which is a high-affinity human immunoglobulin G1 kappa monoclonal antibody and blocks the interaction of PD-L1 with PD-1 and CD80. Currently, there are a number of ongoing trials in advanced urothelial carcinoma both using durvalumab monotherapy and in combination with other targeted therapies. In addition, durvalumab is being investigated in the non-muscle-invasive urothelial carcinoma, which is centered around intravenous formulations. These exciting developments have added a significant number of therapies in a previously limited treatment landscape

Low number of mitochondrial pseudogenes in the chicken (Gallus gallus) nuclear genome: implications for molecular inference of population history and phylogenetics

BACKGROUND: Mitochondrial DNA has been detected in the nuclear genome of eukaryotes as pseudogenes, or Numts. Human and plant genomes harbor a large number of Numts, some of which have high similarity to mitochondrial fragments and thus may have been inadvertently included in population genetic and phylogenetic studies using mitochondrial DNA. Birds have smaller genomes relative to mammals, and the genome-wide frequency and distribution of Numts is still unknown. The release of a preliminary version of the chicken (Gallus gallus) genome by the Genome Sequencing Center at Washington University, St. Louis provided an opportunity to search this first avian genome for the frequency and characteristics of Numts relative to those in human and plants. RESULTS: We detected at least 13 Numts in the chicken nuclear genome. Identities between Numts and mitochondrial sequences varied from 58.6 to 88.8%. Fragments ranged from 131 to 1,733 nucleotides, collectively representing only 0.00078% of the nuclear genome. Because fewer Numts were detected in the chicken nuclear genome, they do not represent all regions of the mitochondrial genome and are not widespread in all chromosomes. Nuclear integrations in chicken seem to occur by a DNA intermediate and in regions of low gene density, especially in macrochromosomes. CONCLUSION: The number of Numts in chicken is low compared to those in human and plant genomes, and is within the range found for most sequenced eukaryotic genomes. For chicken, PCR amplifications of fragments of about 1.5 kilobases are highly likely to represent true mitochondrial amplification. Sequencing of these fragments should expose the presence of unusual features typical of pseudogenes, unless the nuclear integration is very recent and has not yet been mutated. Metabolic selection for compact genomes with reduced repetitive DNA and gene-poor regions where Numts occur may explain their low incidence in birds

Volume Viscosity in Fluids with Multiple Dissipative Processes

The variational principle of Hamilton is applied to derive the volume viscosity coefficients of a reacting fluid with multiple dissipative processes. The procedure, as in the case of a single dissipative process, yields two dissipative terms in the Navier-Stokes equation: The first is the traditional volume viscosity term, proportional to the dilatational component of the velocity; the second term is proportional to the material time derivative of the pressure gradient. Each dissipative process is assumed to be independent of the others. In a fluid comprising a single constituent with multiple relaxation processes, the relaxation times of the multiple processes are additive in the respective volume viscosity terms. If the fluid comprises several relaxing constituents (each with a single relaxation process), the relaxation times are again additive but weighted by the mole fractions of the fluid constituents. A generalized equation of state is derived, for which two special cases are considered: The case of low-entropy production, where entropy variation is neglected, and that of high entropy production, where the progress variables of the internal molecular processes are neglected. Applications include acoustical wave propagation, Stokes flow around a sphere, and the structure and thickness of a normal shock. Finally, it is shown that the analysis presented here resolves several misconceptions concerning the volume viscosity of fluids. © 2009 American Institute of Physics

Variational Approach to the Volume Viscosity of Fluids

The variational principle of Hamilton is applied to develop an analytical formulation to describe the volume viscosity in fluids. The procedure described here differs from those used in the past in that a dissipative process is represented by the chemical affinity and progress variable (sometimes called order parameter ) of a reacting species. These state variables appear in the variational integral in two places: first, in the expression for the internal energy, and second, in a subsidiary condition accounting for the conservation of the reacting species. As a result of the variational procedure, two dissipative terms appear in the Navier-Stokes equation. The first is the traditional volume viscosity term, proportional to the dilatational component of velocity; the second term is proportional to the material time derivative of the pressure gradient. Values of the respective volume viscosity coefficients are determined by applying the resulting volume-viscous Navier-Stokes equation to the case of acoustical propagation and then comparing expressions for the dispersion and absorption of sound. The formulation includes the special case of equilibration of the translational degrees of freedom. As examples, values are tabulated for dry and humid air, argon, and sea water. © 2006 American Institute of Physics

Prompting consumers to make healthier food choices in hospitals : a cluster randomised controlled trial

Funding The study was funded by the Royal Society of Edinburgh through a Sabbatical Research Award to JA (Award ID: 59117). DP is supported by the strategic research programme funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division Acknowledgements The authors wish to thank the Royal Voluntary Service for hosting the study and in particular Andrew Roberts, Philip Hurley and Steven Waite for enabling access to the necessary sites, retail staff and purchasing data.Peer reviewedPublisher PD