Conscious Brain Mind-Controlled Cybonthitic Cyborg Bionic-Leg -- V2

Lower limb amputations affect about 28.9 million people worldwide, influencing normal human functions, we are developing a conscious brain mind-controlled Cybonthitic cyborg bionic-leg to provide a professional solution for this problem, which is classified as restricted knee movement, short-term solution, limited pressure bearing, unspecific analog reading of EMG; Because the output voltage measured in nano-volts, resulting in unspecific knee movement. The functionality of these modern gadgets is still limited due to a lack of neuromuscular control (i.e. For movement creation, control relies on human efferent neural signals to peripheral muscles). Electromyographic (EMG) or myoelectric signals are neuromuscular control signals that can be recorded from muscles for our engineering goals. We worked on a sophisticated prosthetic knee design with a 100-degree angle of motion. We also used a specific type of coiled spring to absorb abrupt or unexpected motion force. In addition, we amplified the EMG output from (Nano-Voltage) to (Milli-Voltage) using customized instrumentation amplifiers (operational amplifiers). We used a full-wave rectifier to convert AC to DC, as a consequence of these procedures, sine-wave output voltage measures in millivolts, and the spring constant indicates the most force for every 1cm. Von mises Stress analysis shows bearing as 3000N is the maximum load for the design. Detecting the edge of a stairwell using the first derivative. The benefit of a system that controls the prosthetic limb is activated by the patient's own EMG impulses, rather than sensors linked to the body

Validation of a modified cow’s milk-related symptom score (CoMISS) for screening of lactose intolerance in adults

Introduction: Lactose intolerance (LI) is the failure to digest foods and beverages containing the lactose present in milk. LI can present by many digestive symptoms. Objective: To validate the modified CoMiSS score for prediction of LI, that was confirmed by a stool acidity test. Patients and methods: A cross-sectional study, was conducted at Ain Shams University Hospitals/Gastrointestinal Clinics, and included one hundred adult participants during the period from December 2018 to December 2019. Enrolled patients had one or more gastrointestinal symptoms and were subjected to a stool acidity test (fecal PH test) as a reference test and modified CoMiSS as an index test. Results: The mean age of participants was 35.30 ± 10.714 years old; 55% were females, and their mean body mass index (BMI) was 23.08 ± 2.080 kg/m2, with no significant relation between LI and patients` gender or BMI. Out of the studied participants 24% had positive stool PH, LI diagnosed according to modified CoMISS was present among 19% of them. The mean value of modified CoMISS Score was significantly higher in positive cases (12.37) compared to negative LI participants (2.33) as p < .001. Area under ROC Curve was 0.998, at the selected cut-off value 8, the sensitivity was 89.5% and specificity was 100% thus, levels of questionnaire scoring of 8 or higher would indicate presence of lactose intolerance. Conclusion: Modified CoMiSS is a simple, fast, and easy-to-use tool that can predict LI, with a cut-off value of >8, the Area under the ROC Curve was 0.998, sensitivity 89.5%, and specificity was 100%

Foreign body ingestion in children: unusual presentations and timely intervention

Background/purpose: Foreign body (FB) ingestion in children is very common. Children can ingest a wide variety of FBs. Most of the ingested FBs pass spontaneously through the gastrointestinal tract. Other FBs, especially uncommonly ingested objects, can present with complications and need intervention to be extracted. The aim of this study was to highlight the importance of timely intervention to extract these FBs.Patients and methods: Between November 2012 and October 2017, patients who presented to our department with variously ingested FBs were retrospectively reviewed to detect those who needed intervention (surgical or endoscopic) to extract these FBs.Results: During the specified time period, 480 patients with FB ingestion presented to our department. Out of these children, 12 patients ingested uncommon FBs or presented with symptoms of complications of impaction and needed intervention to extract these FBs. Three patients ingested multiple magnets. Three patients ingested pins which were impacted in and penetrated the duodenum. One patient ingested a screw which was impacted in the appendix. One patient ingested a sticky rubber toy which was impacted in the pylorus. One patient ingested hair (bezoar), which was also impacted in the pylorus. One patient ingested a disk battery which was impacted in and penetrated the esophagus, and all were surgically extracted. One patient had a slipped stent of repaired choanal atresia which was impacted in the gastroesophageal junction and one patient with repaired tracheoesophageal fistula ingested a stone which was impacted at the site of esophageal anastomosis, and both were endoscopically retrieved.Conclusion: Children who ingested uncommon FBs or presented late with symptoms of complications of impaction needed intervention (surgically or endoscopically) to extract these FBs.Keywords: foreign bodies, foreign body extraction, ingestion, magnets ingestion, pin ingestio

Snake Bite in Gezira Revision of 63 Envenomed Child

&nbsp;&nbsp; Sixty three patients admitted to the Gezira National Center of Pediatric Surgery with snake bite were analyzed. All patients were envenomed and the snake was positively identified. In 39 patients (61.9%) the offending snake was (washash) (Echis carinatus) and in 24 patients (38.1%) (Abdafan) (atractaspis microlepidata) was identified. All patients were from rural Gezira where children are actively involved in agriculture and harvesting. The median age group was 9.3 years. Females were equally involved as males. The mean time elapsed since the bite was 56 hours. Quicker arrival at hospital was seen in severe envenomation. Fifty patients had already received native remedies which was observed to increase the local wound complications. Most bites (79%) occurred in the leg .The majority of the bites occurs in the early rainy summer months. All patients presented initially with progressive painful swelling. Local necrosis was observed in seventeen patients (26.9%). &nbsp;Fourteen patients (22.2%) developed compartment syndrome and three patients (4.76%) developed fingertip gangrene. one patient (1.6%) developed extensive bilateral common iliac vein thrombosis. DIC developed in 21 patients (33.3%). Two patients (3.2%) of theses developed intracranial haemorrhage. Four patients (6.3%) with local necrosis presented few month later with extensive chronic osteomyelitis.Treatment options included cardiovascular support, local wound debridement, fasciotomy and minor amputation. Patients with DIC were managed with fresh frozen plasma, blood transfusion and heparin. Antivenin was not administered to our patients. All patients eventually recovered except one child (1.6%) who succumbed of massive intracerebral haemorrhage. ملخص: &nbsp;تم تحليل البيانات لثلاث وستين طفلا تم تنويمهم بمركز الجزيرة القومي لجراحة الأطفال في الفترة من مارس 2001م الي ابريل2010م&nbsp; بعد أن شخصت حالتهم بلدغة ثعبان سام. في كل المرضى تم التعرف على الثعبان, في 39 مريض كان الثعبان اللادغ من نوع و شاش(echis carinatus) &nbsp;وفي 24 أبو دفان (atractaspis &nbsp;&nbsp;(micolepidata كل المرضي كانوا أطفالا من أرياف الجزيرة وجميعهم يعمل في الزراعة والحصاد. بلغ متوسط العمر لديهم 9.3 سنة. كانت الإصابة متساوية لدي الذكور والإناث, متوسط الوقت المنصرم منذ اللدغة بالثعبان وحتى ألمجي للمستشفي&nbsp; كانت 56 ساعة ,لوحظ إن ألمجي الباكر للمستشفي يكون في حالات التسمم الوخيم . المعالجة لهؤلاء المرضي تضمنت مساعدة الجهاز الدوري وانضار الجرح الموضعي و بضع اللفافة وإجراء البتر البسيط ,المرضي اللذين عانوا من التخثر المنتشر داخل الأوعية الدموية تمت معالجتهم بحقن المصورة المتجمدة الطازجة ونقل الدم الطازج واعطا الهبارين. لم يتم استخدام الترياق في أي من المرضي. كل المرضي تماثلوا للشفاء إلا مريضا واحدا توفي بسبب نزف جسيم داخل القحف.&nbsp;&nbsp;&nbsp;&nbsp

Epidemiological and pathological screening of suspected cases of contagious bovine pleuropneumonia in Yola Modern Abattoir, Adamawa State Nigeria

Contagious bovine pleuropneumonia is an important infectious disease of cattle caused by Mycoplasma mycoides subsp. mycoides and a major constraint to cattle production in sub-Saharan Africa. This study was aimed to identify pathological and histopathological lesions identified in cattle tentatively diagnosed with CBPP at Yola Modern Abattoir, Adamawa State. A total of 9,750 cattle were examined at post-mortem for a period of six months, 110 (1.13%) had lesions suggestive of CBPP out of which seventeen (17) were randomly selected and processed for histopathology based on standard laboratory protocols. Based on sex, CBPP lesion was observed more in female 63 (1.06%) than in the male 47 (1.24%). Whereas, CBPP lesions was observed highest in White Fulani breed 68 (1.14%) followed by Cross breeds 23 (91.16%) and Sokoto Gudali 19 (1.74%) and lowest in Red Bororo 10 (1.36%). There was insignificant statistical association (P&gt;0.05) between CBPP lesions and sex and breed of cattle sampled. Age distribution of CBPP lesion was observed higher in cattle between ages of 4-7 years 79 (1.16%), followed by cattle of 1-3 years 28 (1.15%) and least in cattle less than 1 year 3 (0.60%) with significant statistical difference (P&lt;0.05) between the age groups. Histopathology lesions observed include severe congestion of pulmonary blood vessel in all the lung tissues and fibrin exudation into inter-alveolar spaces with almost all the alveoli collapsed. The bronchiolar epithelium was observed to be thickened, hyperplastic and folded, with a considerable quantity of edematous fluid and numerous inflammatory cells seen in the lumen. In conclusion, this study had demonstrated the presence of CBPP lesions in cattle in the study area. Therefore, serological screening of all cattle, stamping out policies and aggressive annual vaccination campaigns are thus recommended in the study area

Predictors of high calcium score in patients with negative myocardial perfusion imaging

Background: Coronary artery disease (CAD) is one of the major cardiovascular diseases. Myocardial perfusion imaging (MPI) using single photon emission computed tomography (SPECT) plays an important role in the diagnosis and prognosis of CAD.Objective: The aim of the present study was to reduce the generalization of doing calcium score for all coronary cardiac patients with negative myocardial perfusion imaging. Patients and methods: A retrospective cohort study analysis using data from Alfa Scan Center, a major outpatient radiology center in Cairo, Egypt, and conducted in Cardiology Department, Faculty of Medicine, Zagazig University that included a total sample of 1168 participants with negative myocardial perfusion imaging not known to have history of CAD, and age ranged between 20 to 80 years from both sexes. All patients were subjected for SPECT-MPI after the intravenous injection of 99mTc-sestamibi.Results: There was statistically significant difference between the two groups regarding age, gender, weight, chest pain, hypertension, dyslipidemia, diabetes, family history of CAD, beta blockers, aspirin, resting diastolic blood pressure (DBP), rest ECG abnormalities and exercise duration. Age, gender, diabetes mellitus and dyslipidemia were the predictors of any coronary artery calcification (CAC &gt; 0) in patients with negative myocardial perfusion imaging. Age, gender and Duke Treadmill Score were the predictors of significant coronary artery calcification (CAC &gt; 100) in patients with negative myocardial perfusion imaging.Conclusion: Calcium score for all not known coronary cardiac patients with negative MPI is a mandatory, particularly if they are old, male gender and have multiple risk factors

Micro Vascular and Macro Vascular Disease in Systemic Hypertension: The Role of Cardiac Imaging and Nitric Oxide Synthase Gene Polymorphism

Systemic Hypertension (HTN) accounts for the largest amount of attributable Cardiovascular (CV) mortality worldwide. There are several factors responsible for the development of HTN and its CV complications. Multicenter trials revealed that risk factors responsible for Micro Vascular Disease (MVD) are similar for those attributable to Coronary Artery Disease (CAD) which include tobacco use, unhealthy cholesterol levels, HTN, obesity and overweight, physical inactivity, unhealthy diet, diabetes, insulin resistance, increasing age and genetic predisposition. In addition, the defective release of Nitric Oxide (NO) could be a putative candidate for HTN and MVD. This study reviewed the risk stratification of hypertensive population employing cardiac imaging modalities which are of crucial importance in diagnosis. It further emphasized the proper used of cardiac imaging to determine patients at increased CV risk and identify the management strategy. It is now known that NO has an important eff ect on blood pressure, and the basal release of endothelial Nitric Oxide (eNOS) in HTN may be reduced. Although there are diff erent forms of eNOS gene allele, there is no solid data revealing the potential role of the polymorphism of the eNOS in patients with HTN and coronary vascular diseases. In the present article, the prevalence of eNOS G298 allele in hypertensive patients with micro vascular angina will be demonstrated. This review provides an update on appropriate and justified use of non-invasive imaging tests in hypertensive patients and its important role in proper diagnosis of MVD and CAD. Second, eNOS gene allele and its relation to essential hypertension and angina pectoris are also highlighted

The Auditing Quality and Accounting Conservatism

[Abstract] This study aims at verifying that there is accounting conservatism in the financial reports issued by the industrial corporations listed on the Amman Stock Exchange (ASE) and testing the impact of auditing quality characteristics (the auditing firm size, contacts with other global auditing firms, client retention period, auditing fees and the specialty in client&apos;s industry) on the enhancement of the level of accounting conservatism. Towards realizing the objectives of the study, the relationship was estimated and examined through the Binomial Test to test the first hypothesis a One-Sample T-Test to test the second hypothesis, and multiple regressions of (Ordinary Least Squares OLS). Data of 39 companies of the industrial sector for the period 2001-2006 were arranged in a way that made it possible to apply the Pooled Data Regression. The study found significant results indicating a low level of accounting conservatism in the financial statements issued by the Jordanian industrial corporations. The results indicated that some of the characteristics of auditing quality are good, and some of audit quality characteristics have an impact on improving the level of accounting conservatism. Based on these results, we have provided recommendations to the interested parties

Combination of Human Amniotic Fluid Derived-Mesenchymal Stem Cells and Nano-hydroxyapatite Scaffold Enhances Bone Regeneration

BACKGROUND: Human amniotic fluid-derived stem cells (hAF-MSCs) have a high proliferative capacity and osteogenic differentiation potential in vitro. The combination of hAF-MSCs with three-dimensional (3D) scaffold has a promising therapeutic potential in bone tissue engineering and regenerative medicine. Selection of an appropriate scaffold material has a crucial role in a cell supporting and osteoinductivity to induce new bone formation in vivo. AIM: This study aimed to investigate and evaluate the osteogenic potential of the 2nd-trimester hAF-MSCs in combination with the 3D scaffold, 30% Nano-hydroxyapatite chitosan, as a therapeutic application for bone healing in the induced tibia defect in the rabbit. SUBJECT AND METHODS: hAF-MSCs proliferation and culture expansion was done in vitro, and osteogenic differentiation characterisation was performed by Alizarin Red staining after 14 &amp; 28 days. Expression of the surface markers of hAF-MSCs was assessed using Flow Cytometer with the following fluorescein-labelled antibodies: CD34-PE, CD73-APC, CD90-FITC, and HLA-DR-FITC. Ten rabbits were used as an animal model with an induced defect in the tibia to evaluate the therapeutic potential of osteogenic differentiation of hAF-MSCs seeded on 3D scaffold, 30% Nano-hydroxyapatite chitosan. The osteogenic differentiated hAF-MSCs/scaffold composite system applied and fitted in the defect region and non-seeded scaffold was used as control. The histopathological investigation was performed at 2, 3, &amp; 4 weak post-transplantation and scanning electron microscope (SEM) was assessed at 2 &amp; 4 weeks post-transplantation to evaluate the bone healing potential in the rabbit tibia defect. RESULTS: Culture and expansion of 2nd-trimester hAF-MSCs presented high proliferative and osteogenic potential in vitro. Histopathological examination for the transplanted hAF-MSCs seeded on the 3D scaffold, 30% Nano-hydroxyapatite chitosan, demonstrated new bone formation in the defect site at 2 &amp; 3 weeks post-transplantation as compared to the control (non-seeded scaffold). Interestingly, the scaffold accelerated the osteogenic differentiation of AF-MSCs and showed complete bone healing of the defect site as compared to the control (non-seeded scaffold) at 4 weeks post-transplantation. Furthermore, the SEM analysis confirmed these findings. CONCLUSION: The combination of the 2nd-trimester hAF-MSCs and 3D scaffold, 30% Nano-hydroxyapatite chitosan, have a therapeutic perspective for large bone defect and could be used effectively in bone tissue engineering and regenerative medicine

Prognosis of Liver Disorders in Dna Positive Hbv Patients Based on Fuzzy Soft Sets

Liver disease and disorders are serious public health burdens because of the high prevalence among populations worldwide and poor long-term clinical outcome. The outcomes of the disease include deaths from liver decompensation, cirrhosis and HCC. Many liver diseases, including chronic HBV and HCV infection, ALD, NAFLD, autoimmune liver disease and drug-induced liver disease (DILI), potentially threaten a large proportion of the global population. The fuzzy soft set principle theory has been used for the developing of a diagnostic system in medicine and devise a prediction system named as fuzzy soft expert system which is a rule-based system uses fuzzy set and fuzzy soft set. There are five main components included in the basic structure, they are: (1) A fuzzication that translates the inputs (real-values) into fuzzy values, (2) obtaining fuzzy sets, (3) changing in to fuzzy soft sets, (4) reduction of normal parameter of fuzzy soft sets, (5) output data by algorithm. Fifty two individuals suspected and managed as HBV patients were involved in this study.All of them were attending liver diseases unit at Azadi teaching hospital in Duhok, Kurdistan Region-Iraq. They were being managed by the herpetology specialist as HBV infected patients. Their parameters (Alanine Aminotransferase (ALT), Aspartate aminotransferase (AST), Total Serum Albumin (Alb.), and Total Serum Bilirubin (T.S.Bil.)), were used as input data and the score of each patient was calculated. The developed fuzzy soft expert system was used to obtain the score for each as prognostic model for liver disorders. The score of 10 of those patients are selected and compared with the clinical status of each base on signs and symptoms of the HBV infection. Score more than 101.844 was considered to be highly linked with HBV infection. Scores less than 101.844 was considered to be not related to HBV infection