Dengue Hemorrhagic fever complicated by intercostal artery hemorrhage.

Hemorrhagic manifestations are fairly common in Dengue hemorrhagic fever and are associated with increased mortality. During last few decades there have been increasing reports of Dengue infection with unusual manifestations. Here we present a case of dengue hemorrhagic fever complicated by spontaneous rupture of an intercostal artery leading to a large hematoma which was treated successfully with angio-embolization. To the authors\u27 knowledge this is a first case of dengue hemorrhagic fever complicated by spontaneous intercostal artery hemorrhage

Photoplethysmography temporal marker-based machine learning classifier for anesthesia drug detection

Anesthesia drug overdose hazards and lack of gold standards in anesthesia monitoring lead to an urgent need for accurate anesthesia drug detection. To investigate the PPG waveform features affected by anesthesia drugs and develop a machine-learning classifier with high anesthesia drug sensitivity. This study used 64 anesthesia and non-anesthesia patient data (32 cases each), extracted from Queensland and MIMIC-II databases, respectively. The key waveform features (total area, rising time, width 75%, 50%, and 25%) were extracted from 16,310 signal recordings (5-s duration). Discriminant analysis, support vector machine (SVM), and K-nearest neighbor (KNN) were evaluated by splitting the dataset into halve training (11 patients, 8570 segments) and halve testing dataset (11 patients, 7740 segments). Significant differences exist between PPG waveform features of anesthesia and non-anesthesia groups (p  0.05). The KNN classifier achieved 91.7% (AUC = 0.95) anesthesia detection accuracy with the highest sensitivity (0.88) and specificity (0.90) as compared to other classifiers. Kohen’s kappa also shows almost perfect agreement (0.79) with the KNN classifier. The KNN classifier trained with significant PPG features has the potential to be used as a reliable, non-invasive, and low-cost method for the detection of anesthesia drugs for depth analysis during surgical operations and postoperative monitoring. GRAPHICAL ABSTRACT: [Image: see text

The impact of human capital outsourcing on human capital management practices in Karachi pharmaceutical industry

Purpose: The aim of this research is to examine relationship between Human Capital Management (HRM) and Human Resource (HR) Outsourcing in the Pharmaceutical sector. The specific objective is to find out that how important is HRM for an Organization to perform its operations more efficiently, and at what level Human Resource Outsourcing is affecting it. Literature review: Literature review shows that HR outsourcing has positive impact on HRM for an Organization to perform its operations more efficiently. Methods: In order to conduct this research the methodology that has been used is quantitative in nature and closed ended Questionnaire was used to collect data. The universe of study was the employees of Pharmaceutical industry in Karachi Pakistan. The responses of each respondent were thoroughly analyzed by using SPSS software, and the results show that there is a negative relationship between the Human Capital Management (Gaining Knowledge, Current Trend of Business Environment, Organization Managing Their Human Asset and Practices and Policies Regarding Human Resource) and HR Outsourcing. Conclusions: It is concluded that all Independent Variables have the strongest Positive correlation with each other. There are lots of constraints, which any organization faces in terms of time, finance and, in some cases factors like strategic focus.Human Capital Management, Karachi, Pharmaceutical, Outsourcing

Inventory Management System for a General Items Warehouse of the Textile Industry

This research is based on Inventory Management System for a General Items Warehouse of the Textile Industry. The overall inventory is managed by applying classification tools such as ABC, FSN & HML that categorize inventory based on consumption value, issuance rate and unit price respectively. Also, it helps to appropriately position the items on the desired rack and position. The optimized layout is designed that reduces the retrieval time, uplift the storage capacity, and have cross aisles that reduce the retrieval time of any item from the warehouse. The system for proper traceability & tracking of the items is also studied that is based on the 1D Barcode. This whole study improves the overall operation of the Supply Chain

Reduction in Packaging Wastes Through Identification of Lean Wastes to Deliver Efficient Waste Controlling Techniques for a Pharmaceutical Industry

The purpose of this paper is to propose a method of reducing material and time waste during packaging in the pharmaceutical industry. This is done by means of identifying the four major lean wastes i.e., motion, inadequate processing, waiting, and defects. These wastes are identified and reduced by means of using lean tools and proposing other cost-effective solutions that would increase process efficiency. Material waste is dealt with through selecting optimal requirements under the constraint limits of ergonomics, engineering, and machine space availability. Along with reduction in change over time, a strategy ensuring improvement in the primary packaging area was developed. The validity of this research has been brought about by means of a case study of a multinational pharmaceutical company. The proposed system proves to be highly beneficial in ensuring wastage and time reduction in changeovers. This strategy provides improved results without any new costs introduced and the production targets were met faster. There is also a special consideration given to the ergonomic aspect of the production processes

Cutaneous Ulcers as Initial Presentation of Localized Granulomatosis with Polyangiitis: A Case Report and Review of the Literature

Background. Granulomatosis with polyangiitis (GPA) is an ANCA associated small vessel vasculitis characterized by necrotizing granulomatous inflammation involving the upper and the lower respiratory tract and the kidneys. The disease has a broad clinical spectrum that ranges from limited/localized involvement of a single organ system to a generalized systemic vasculitis that affects several organs with evidence of end organ damage. Atypical forms of the disease have been recognized with or without respiratory tract involvement with a long protracted course before manifesting as generalized disease. Case Presentation. We describe a 57-year-old woman who presented with recurrent fever and cutaneous ulcers on her legs who was diagnosed to have granulomatosis with polyangiitis (GPA) after an extensive evaluation which excluded infectious, other vasculitides, connective tissue disease and malignant etiologies. Conclusion. In the absence of typical manifestations, granulomatosis with polyangiitis (GPA) is indeed a diagnostic challenge to the physician. Atypical manifestations like unexplained recurrent fever and cutaneous ulcers nevertheless call for keeping a low threshold for the diagnosis of GPA as the disease can initially present in localized form before heralding into a generalized disease

In-Service Training of Secondary Level Teachers: a Follow up of Teachers' Performance in Comparative Perspective

It was a follow-up study of teachers training in comparative perspective. The study was delimited to all Trained Graduate Teachers (TGTs) working in Federal Government Secondary Schools of Islamabad who received in-service training during years 2005-2009. Out of 1265 TGTs 32 INSET TGTs (with in-service education and training) and 32 NON-INSET TGTs (without in-service education and training), 64 colleague teachers, 256 students and 32 head teachers were selected as sample. One observation schedule and three five point Likert rating scales were used to collect the data on four selected parameters i.e. Classroom Management, Teaching Methodology, Use of AV Aids, and Evaluation Techniques. Mean scores, t-test and SD were applied. Out of five, four null hypotheses were rejected at 0.05 level of significance. It was concluded that the performance of INSET TGTs was comparatively better than the NON-INSET TGTs. The recommendations for training for working teachers and improvement of training contents were made. Keywords: In-service Training, Secondary School Teacher, Teachers' Performance, Follow-up Stud

Co-movement dynamics of US and Chinese stock market: evidence from COVID-19 crisis

This paper aims to examine the co-movement between the two economic powers, namely the USA and China. The authors are mainly interested in examining the dynamics of co-movements during, and in the pre-covid periods. Additionally, they have aimed to examine the volatility spillover between USA and China, during and in the pre-covid periods. In order to achieve the research-based objectives, advanced econometrics models have been applied to the data from July1, 2010, to April 30, 2021. The results show that the sample market is integrated in the long run. The results also indicate that the behaviour of the Chinese market is same as the US market, and offers negligible opportunities for investors for diversification during this time. The findings indicate that the Ganger Causality between the stock markets during crisis is significantly higher than the pre-crisis period. The results of EGARCH model confirm the presence of asymmetric volatility spillover effects between the US and Chinese markets, during the considered time periods. This study also examines the co-movement in China, grounded upon the robust approach that facilitates examining the dependence structure between the sample variables. The findings offer valuable understanding for investors who are looking for investment diversification opportunities worldwide