3,704 research outputs found

    Interfacial reactions between sapphire and Ag-Cu-Ti-based active braze alloys

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    The interfacial reactions between two commercially available Agā€“Cuā€“Ti-based active braze alloys and sapphire have been studied. In separate experiments, Agā€“ 35.3Cuā€“1.8Ti wt.% and Agā€“26.7Cuā€“4.5Ti wt.% alloys have been sandwiched between pieces of R-plane orientated sapphire and heated in argon to temperatures between 750 and 900 Ā°C for 1 min. The phases at the Agā€“Cuā€“ Ti/sapphire interfaces have been studied using selected area electron diffraction, energy dispersive X-ray spectroscopy and electron energy loss spectroscopy. Gradual and subtle changes at the Agā€“Cuā€“Ti/sapphire interfaces were observed as a function of temperature, along with the formation of a transient phase that permitted wetting of the sapphire. Unequivocal evidence is shown that when the active braze alloys melt, titanium first migrates to the sapphire and reacts to dissolve up to ~33 at.% oxygen, forming a nanometre-size polycrystalline layer with a chemical composition of Tiā‚‚Oā‚ā‚‹ā‚“ (x<<1). Tiā‚ƒCuā‚ƒO particles subsequently nucleate behind the Tiā‚‚Oā‚ā‚‹ā‚“ layer and grow to become a continuous micrometre-size layer, replacing the Tiā‚‚Oā‚ā‚‹ā‚“ layer. Finally at 845 Ā°C, a nanometre-size Ī³-TiO layer forms on the sapphire to leave a typical interfacial structure of Agā€“Cu/Tiā‚ƒCuā‚ƒO/Ī³-TiO/sapphire consistent with that seen in samples of polycrystalline alumina joined to itself with these active braze alloys. These experimental observations have been used to establish a definitive bonding mechanism for the joining of sapphire with Agā€“Cu alloys activated by small amounts of titaniumWe are grateful for the financial support for this study provided by AWE.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.actamat.2015.11.01

    Intestinal malrotation and Laddā€™s bands in a young child

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    The case we present, is an interesting example of intestinal malrotation, which is a wellĀ known congenital condition, which tend to manifest early in life. In our case the ageĀ of our patient made the diagnosis potentially more challenging, as it was not the mostĀ typical age for duodenal stenosis due to Laddā€™s bands, which is often mostly observedĀ earlier in life. Stenosis of the duodenum is relatively rare, and may represent a surgicalĀ challenge, especially in setting with limited diagnostic and treatment facilities. WeĀ also discuss implication of language barriers to potentially delay timely diagnosisĀ and optimal management

    Pastoralist knowledge of sheep and goat disease and implications for peste des petits ruminants virus control in the Afar Region of Ethiopia

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    Pastoralist areas of Ethiopia are vulnerable to drought, causing livelihood loss and famine. One approach to increasing pastoralist resilience is the control of livestock disease, but there is limited information from pastoralist areas to inform control strategies. This study aimed to explore pastoralist concepts of small ruminant disease and implications for infectious disease surveillance and control in the pastoralist Afar Region. During 2013ā€“14, qualitative and quantitative methods were applied in two villages of one district in the mid-west of the region. Semi-structured group interviews, incorporating participatory tools, explored pastoralist knowledge of small ruminant diseases and their impact. These were followed by multiple visits in different seasons to 70 households for semi-structured and informal interviews, observation of management practices, clinical examinations, and weekly questionnaires of mortality and morbidity. Thematic analysis was applied to interview transcripts and field notes, and descriptive statistical analysis to quantitative data. Afar concepts of disease causation, terminology and treatment were predominantly naturalistic, related to observable signs and physical causes, rather than personalistic factors (misfortune due to magical or spiritual agents). Disease occurrence was associated with malnutrition and adverse weather, and disease spread with contact between animals during grazing, watering and migration. Disease occurrence varied by season with most syndromes increasing in frequency during the dry season. Names for disease syndromes were related to the main clinical sign or body part affected; 70 terms were recorded for respiratory syndromes, diarrhoea, sheep and goat pox, lameness, skin diseases, ectoparasites, urinary and neurological syndromes and abortion. Some syndromes with pathognomonic signs could be linked to biomedical diagnoses but most were non-specific with several possible diagnoses. The syndromes causing greatest impact were diarrhoea and respiratory disease, due to mortality, reduced milk production, weight loss, abortion, weak offspring and reduced market value. Afar applied a range of traditional methods and modern medicines to prevent or treat disease, based on livestock keeper knowledge, advice of local specialists and occasionally advice from district veterinarians or animal health workers. In relation to surveillance for peste des petits ruminants (PPR), several terms were used for PPR-like syndromes, depending on the predominance of respiratory or diarrhoea signs. Therefore, whenever these terms are encountered during surveillance, the associated disease events should be fully investigated and samples collected for laboratory confirmation. The Afar naturalistic concepts of disease parallel biomedical concepts and provide a good foundation for communication between veterinarians and pastoralists in relation to PPR surveillance and control measures

    Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

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    The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the photoreceptor-mediated a-wave, but not in restoration of the bipolar cell-mediated b-wave. Here we show that a mutation in Gpr179 prevents the full restoration of vision in rd1 mice. Backcrossing rd1 with C57BL6 mice reveals the complete lack of b-wave in a subset of mice, consistent with an autosomal recessive Mendelian inheritance pattern. We identify a mutation in the Gpr179 gene, which encodes for a G-protein coupled receptor localized to the dendrites of ON-bipolar cells. Gene replacement in rd1 mice that are devoid of the mutation in Gpr179 successfully restores the function of both photoreceptors and bipolar cells, which is maintained for up to 13 months. Our discovery may explain the failure of previous gene therapy attempts in rd1 mice, and we propose that Grp179 mutation status should be taken into account in future studies involving rd1 mice

    Tracking neuronal motility in live murine retinal explants

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    The developing retina undergoes dynamic organizational changes involving significant intra-retinal motility of the encompassing cells. Here, we present a protocol for tracking retinal cell motility in live explanted mouse retinae. Although originally applied to rod and cone photoreceptors, this strategy is applicable to any fluorescently labeled cell in mouse retinae and other similar experimental retinal models. Careful tissue handling is critical for the successful acquisition of high-quality live imaging data. Further instructions for semi-automated in silico data handling are provided. For complete details on the use and execution of this protocol, please refer to Aghaizu et al. (2021)

    ANALISIS RUGI-RUGI DAYA KABEL DC PADA PLTS 1MWP ON-GRID INSTITUT TEKNOLOGI SUMATERA BERDASARKAN DATA FUSION SOLAR

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    PLTS 1 MWp on-grid at the Sumatra Institute of Technology (ITERA) campus comprises solar modules, inverters, DC cables, and protection equipments assembled in a compact system. Each of these components has a role in transmitting the electrical energy generated by the solar module to the electrical load at ITERA. This paper will discuss the power losses generated by PLTS components, especially the DC distribution cables used. The simulation of PVSystV6.81 obtained 1.98% of the losses resulting from the distribution process on the DC cable. The simulation results were compared with the measurement results from the solar fusion software, which records the power components generated by PLTS ITERA such as voltage, current, power, etc. for each string connected to the inverter with a data collection duration of 5 minutes (12 hours per day 06.00 ā€“ 18.00). Based on data obtained from fusion solar in August and formula calculation, the lowest average percentage loss of energy from DC cables is 0.6542% on inverter 6, and the highest is 0.6718% on inverter 1. The difference losses of each inverter are caused by disturbances in the DC cable distribution line from the module to each inverter, such as short circuit current to ground

    Variety of Characteristic Magnetic Material on Permanent Magnet Synchronous Generator (PMSG)

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    Wind energy conversion system, one of the main components is a Permanent Magnet Synchronous Generator (PMSG). During the past two decades, many types of per- manent magnet generators for wind power applications have been the research topic. This study focuses primarily on designing a PMSG to create, simulate, and analyze an internal permanent magnet topology with twelve plots and eight poles. We limit with the simulation was carried out at a rotational speed of 1000rpm, and a type of permanent magnet material, Ceramic 11, SmCo 26/26, and NdFeB 48/11. The result of the analysis is that permanent magnets applied in the design of a generator impact its output power and efficiency. At 15 Ī© and 60 Ī© loads, SmCo 26/26 and NdFeB 48/11 are the only ones that fulfill the specified requirements in this investigation. The permanent magnet type with the most optimal characteristics is Neodymium Iron Boron 48/11 because it has a high flux density, thus causing the electrical energy generated to be greater than other types of permanent magnets. The 48/11 NdFeB permanent magnet generates the most output power, 2110.86 W when loaded with 15 Ī©. The best efficiency of 89.38 percent for the PMSG 12 slot eight poles occurs when the load is 15 on the 48/11 NdFeB permanent magnet
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