Campagna di scavi ISCAB-FTL e USI alla grotta 11Q di Qumran, marzo 2017

The paper presents the report about the excavation campaign at Qumran cave 11Q, carried out from 9th to 19th March 2017 by the Istituto di cultura e archeologia delle terre bibliche of the Facoltà di Teologia di Lugano (ISCAB-FTL) and by the Università della Svizzera Italiana (USI). Previous archaeological excavations, undertaken by Roland de Vaux (1956) and Joseph Patrick (1988 and 1991), were published in brief preliminary reports only. The 2017 archaeological campaign, complemented by speleological and geological investigation, enriched the dossier for the forthcoming final report. Among the main results are: the discovery of an upper chamber; the opening of a sounding in an area barely interested by previous excavations; the analysis of the entrance area and the natural factors which may concur to the closure of the cave; the documentation of 11Q morphology employing modern technology (3D scan)

Evoluzione recente del litorale nella Liguria di Ponente: l'impatto delle opere antropioche; litorale tra Capo S. Spirito e Capo Caprazoppa

Dottorato di ricerca in scienze ambientali: scienza del mare. 12. ciclo. Coordinatore Antonio Brambati. Tutore Giuliano FierroConsiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome; Biblioteca Nazionale Centrale - P.za Cavalleggeri, 1, Florence / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Notes from the 2017 Excavation of Cave 11Q

Notes from the 2017 Excavation of Cave 11

An increase in MYC copy number has a progressive negative prognostic impact in patients with diffuse large B-cell and high-grade lymphoma, who may benefit of intensified treatment regimens

MYC translocations, a hallmark of Burkitt lymphoma, occur in 5-15% of diffuse large B-cell lymphoma, with a negative prognostic impact. Numerical aberrations of MYC have also been detected in these patients, but their incidence and prognostic role are still controversial. We analyzed the clinical impact of MYC increased copy number on 385 patients with diffuse large B-cell lymphoma screened at diagnosis for MYC, BCL2, and BCL6 rearrangements. We enumerated the number of MYC copies, defining amplified those cases with an uncountable number of extra-copies. The prevalence of MYC translocation, increased copy number and amplification was 8.8%, 15%, and 1%, respectively. Patients with 3 or 4 gene copies, accounting for more than 60% of patients with MYC copy number changes, had a more favorable outcome compared to patients with >4 copies or translocation of MYC, and were not influenced by the type of treatment received as first-line. Stratification according to the number of MYC extra-copies showed a negative correlation between an increasing number of copies and survival. Patients with >7 copies or the amplification of MYC had the poorest prognosis. Patients with >4 copies of MYC showed a similar, trending towards worse prognosis compared to patients with MYC translocation. The survival of patients with >4 copies, translocation or amplification of MYC seemed to be superior if intensive treatments were used. Our study underlines the importance of fluorescence in situ hybridization testing at diagnosis of diffuse large B-cell lymphoma to detect the rather frequent and clinically significant numerical aberrations of MYC