KINEMATIC PROFILE OF THE ELITE HANDCYCLIST

A handcycle is a relatively new sports equipment that is a combination of the traditional race wheelchair and a hand operated bicycle crank (Abel, Schneider, Platen, & Struder, 2006). The high mechanical efficiency of this geared fixed-frame racing cycle in comparison to a manual wheelchair can potentially increase the distance a person with a loss of lower limb function can travel. To guide the optimal setup for the handcyclist the influence of crank length (Goosey-Tolfrey, Alfano, & Fowler, 2008; Kramer, Hilker, & Bohm, 2009) and crank configuration (Faupin, Gorce, Meyer, & Thevenon, 2008a; Mossberg, Willman, Topor, Crook, & Patak, 1999) have been investigated. Actual neither research has been done on the upper body kinematics of elite athletes nor on relations between kinematics and performance. The aim of this study was to provide first sport specific information in this area with regards to athletes competing at an international level

Movement in low gravity environments (MoLo) programme The Molo-L.O.O.P. study protocol

The aim of this paper is to define an experimental protocol and methodology suitable to estimate in high-fidelity hypogravity conditions the lower limb internal joint reaction forces. State-of-the-art movement kinetics, kinematics, muscle activation and muscle-tendon unit behaviour during locomotor and plyometric movements will be collected and used as inputs (Objective 1), with musculoskeletal modelling and an optimisation framework used to estimate lower limb internal joint loading (Objective

Electron paramagnetic resonance and other properties of hydrogenases isolated from Desulfovibrio vulgaris (strain Hildenborough) and Megasphaera elsdenii

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65872/1/j.1432-1033.1983.tb07727.x.pd

Redox properties of the iron-sulfur clusters in activated Fe-hydrogenase from Desulfovibrio vulgaris (Hildenborough)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65750/1/j.1432-1033.1992.tb17261.x.pd

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

Cilia are multi-functional organelles that are constructed using intraflagellar transport (IFT) of cargo to and from their tip. It is widely held that the retrograde IFT motor, dynein-2, must be controlled in order to reach the ciliary tip and then unleashed to power the return journey. However, the mechanism is unknown. Here, we systematically define the mechanochemistry of human dynein-2 motors as monomers, dimers, and multi-motor assemblies with kinesin-II. Combining these data with insights from single-particle electron microscopy, we discover that dynein-2 dimers are intrinsically autoinhibited. Inhibition is mediated by trapping dynein-2’s mechanical “linker” and “stalk” domains within a novel motor-motor interface. We find that linker-mediated inhibition enables efficient transport of dynein-2 by kinesin-II in vitro. These results suggest a conserved mechanism for autoregulation among dimeric dyneins, which is exploited as a switch for dynein-2’s recycling activity during IFT