1,355 research outputs found

    Lokale Geschäftsmodelle zur Bearbeitung des mittleren Marktsegments in China : Ergebnisbericht

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    Die Studie analysiert Chancen und Risiken, denen sich der deutsche Maschinenbau durch die dynamische Entwicklung des chinesischen Marktes ausgesetzt sieht. Um das Wachstumspotenzial des chinesischen Marktes in vollem Umfang auszunutzen und sich frühzeitig gegenüber aufstrebenden lokalen Wettbewerbern zu positionieren, liefert die Studie Handlungsempfehlungen zur Bearbeitung des mittleren Marktsegments in China. Die Erkenntnisse der Studie beruhen auf der Auswertung von 115 schriftlich beantworteter Fragebögen sowie 58 Interviews mit Unternehmensvertretern und Branchenexperten, was sie zu einer der umfangreichsten und repräsentativsten Untersuchungen über den deutschen Maschinenbau in China macht

    Supplement to Grundtvig-Studier 1972

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    Supplement til Grundtvig-Studier 1972 Holger Kjær: Højskolens Grund. Kolding 1971, 139 pages, 32 kr. 20 øre.Reviewed by William Michelsen. (Grundtvig-Studier 1972). Ebbe Kløvedal Reich: Frederik. A popular book about the life and times of N. F. S. Grundtvig. Reviewed by Gustav Albeck. (Grundtvig-Studier 1972 ).

    Børns rum og bevægelse på Vesterbro

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    I denne rapport offentliggører vi resultaterne af en undersøgelse af børns og deres familiers oplevelse af og syn på deres muligheder for fysisk bevægelse på Vesterbro italesat i sprog og billeder. Undersøgelsen belyser børns og deres familiers egne oplevelser af eksisterende muligheder for idræt, leg og fysisk udfoldelse på Vesterbro. Undersøgelsens resultater giver et interessant indblik i, hvad der medvirker til at fremme eller hindre børns og deres familiers fysiske aktivitet i deres hverdag på Vesterbro

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    PrefaceBy the editors

    Skrifter udgivet af Grundtvig-Selskabet

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    Works published by the Grundtvig Societ

    Fra Grundtvigs korrespondance med nordmænd. Tre norske breve til Kapellanen i Udby

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    From Grundtvigs Correspondence with Norwegians. Three Letters to the Curate in Udbye. By Gustav Albeck. From Grundtvig’s extensive correspondence with Norwegians this essay brings to light three letters which together form a little “Sunbeam” — the story of an oldish, stagnated Norwegian student, Johan Walsen, whom the young Grundtvig, soon after he had become his father’s curate in Udby in 1811—12, got sent home to Bergen. The first letter is from Walsen’s mother, who expresses her grief at her son’s pitiable condition, but fears that he cannot be helped. The second, hitherto unpublished, is an extract from a very important letter from Jonas Rein, dated Feb. 25th, 1812, a letter which in the edition of Grundtvig’s Letters by Georg Christensen and Stener Grundtvig, Vol. I, p. 62—63, in wrongly attributed to Nordahl Brun. Rein fears, that Bergen will not be a good place for Walsen to live. Grundtvig, however, had not waited for his answer, but seen to it that Walsen was sent home (via Sweden) in Feb., 1812. The third letter is from Walsen and is dated from Bergen on March 7th, 1812. In it he tells of his arrival home and thanks Grundtvig and his father for the good help, they gave him. In the letter Walsen confesses that during his journey he became more firmly convinced that “man without God’s guidance is nothing”, and exclaims, “Thank God . . . I am saved” . We have little information about what happened to Walsen afterwards. We know, however, that in 1838 he published a devotional book with morning and evening hymns, as well as “hymns and prayers for the day when we go to the Lord’s table” . The essay also urges that an edition of Grundtvig’s extensive correspondence with Norwegians should be published, as a companion piece to the great edition of Bjørnson’s correspondence with Danes, which has recently appeared with the support of the Fund for Danish-Norwegian Co-operation

    Skrifter udgivet af Grundtvig-Selskabet

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    Works published by the Grundtvig Societ

    Skrifter udgivet af Grundtvig-Selskabet

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    Works published by the Grundtvig Societ

    The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFÎşB signaling pathway and nitric oxide induction in macrophages

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    <p>Abstract</p> <p>Background</p> <p>LPS-activated macrophages produce mediators which are involved in inflammation and tissue injury, and especially those associated with endotoxic shock. The non toxic tellurium compound ammonium tri-chloro(dioxoethylene-O,O'-)tellurate, AS101, has been recently shown to exert profound anti-inflammatory properties in animal models, associated with its Te(IV) redox chemistry. This study explores the anti-inflammatory properties of AS101 with respect to modulation of inflammatory cytokines production and regulation of iNOS transcription and expression in activated macrophages via targeting the NFkB complex.</p> <p>Results</p> <p>AS101 decreased production of IL-6 and in parallel down-regulated LPS-induced iNOS expression and NO secretion by macrophages. AS101 reduced IkB phosphorylation and degradation, and reduced NFkB nuclear translocalization, albeit these effects were exerted at different kinetics. Chromatin immunoprecipitation assays showed that AS101 treatment attenuated p50-subunit ability to bind DNA at the NFkB consensus site in the iNOS promotor following LPS induction.</p> <p>Conclusions</p> <p>Besides AS101, the investigation of therapeutic activities of other tellurium(IV) compounds is scarce in the literature, although tellurium is the fourth most abundant trace element in the human body. Since IKK and NFkB may be regulated by thiol modifications, we may thus envisage, inview of our integrated results, that Te(IV) compounds, may have important roles in thiol redox biological activity in the human body and represent a new class of anti-inflammatory compounds.</p

    Tolerance to Sound Intensity of Binaural Coincidence Detection in the Nucleus Laminaris of the Owl

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    Neurons of the owl's nucleus laminaris serve as coincidence detectors for measurement of interaural time difference. The discharge rate of nucleus laminaris neurons for both monaural and binaural stimulation increased with sound intensity until they reached an asymptote. Intense sounds affected neither the ratio between binaural and monaural responses nor the interaural time difference for which nucleus laminaris neurons were selective. Theoretical analysis showed that high afferent discharge rates cause coincidence detectors with only excitatory input to lose their selectivity for interaural time difference when coincidence of impulses from the same side becomes as likely as that of impulses from the two sides. We hypothesize that inhibitory input whose strength increases with sound intensity protects nucleus laminaris neurons from losing their sensitivity to interaural time difference with intense sounds
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