Synthesis, Characterization And Anti-Proliferation Study Of Some Benzimidazole Derivatives

Four different types of compounds were successfully synthesized and characterized. The syntheses of these compounds involved benzylation, addition elimination and cyclization reactions. The structures of the synthesized compounds were confirmed by melting points, FTIR, HRMS, 1D and 2D NMR spectroscopy and X–ray crystallography. The first type of these compounds is 2-benzyloxy-3- methoxybenzaldehyde 75, which was synthesized by the reaction of o-vanillin with benzyl bromide in acetone as the solvent and K2CO3 as a base in the presence of tetra-n-butylammonium iodide (TBAI) as catalyst

1D and 2D NMR studies of BENZYL O–VANILLIN

The reaction of o–vanillin A with benzyl bromide B2 in acetone as the solvent and K2CO3 as a base in the presence of tetra–n–butylammonium iodide (TBAI) as catalyst formed benzyl o–vanillin, C. The complete assignments of C using PROTON, APT, DEPT–135, COSY, NOESY, HMQC and HMBC NMR in both CDCl3 and acetone–d6 are discussed, and the coupling constants J are reported in Hertz (Hz)

1D and 2D NMR studies of 2–(2–(BENZYLOXY)–3–METHOXYPHENYL)–1H–BENZIMIDAZOLEF

The reaction of Benzyl o–vanillin 1 and o–phenylene diamine 2 in dichloromethane produced new benzimidazole, 3. The complete assignments of 3 were made using 1D and 2D NMR including COSY, HMQC and HMBC NMR in CDCl3 and acetone–d6. The coupling constants J are reported in Hertz, and the differences in the peak splittings using both solvents are discusse

Microwave-assisted and thermal synthesis of calix[4]arene derivatives

Some tert-butylcalix[4]arene derivatives were synthesized by thermal and microwave methods. The microwave method was conducted in two ways: (1) all the reactants were added in one batch and (2) the reactants were added in two batches under different conditions. Tetrabutylammonium iodide (TBAI) was used in both methods, and its effect on the reaction rate was studied. In general, the duration of the microwaveassisted reactions in the presence of TBAI, especially in the two-batch method, was shorter, and the yields were higher, than in the thermal reaction. The highest yield of (S)-glycidyl calixarene derivative by the thermal method was obtained by using K2CO3 as a base with MeCN as a solvent in the presence of TBAI, while the lowest yield of the same compound was observed when using acetone in the absence of TBAI. All the synthesized calix[4]arene derivatives were characterized by 1H and 13C NMR experiments

1D AND 2D NMR STUDIES OF 2–(2–(BENZYLOXY)–3–METHOXYPHENYL)–1H–BENZIMIDAZOLE

The reaction of Benzyl o-vanillin 1 and o-phenylene diamine 2 in dichloromethane produced new benzimidazole, 3. The complete assignments of 3 were made using 1D and 2D NMR including COSY, HMQC and HMBC NMR in CDCl3 and acetone-d6. The coupling constants J are reported in Hertz, and the differences in the peak splittings using both solvents are discussed.   Keywords: 1H NMR; 13C NMR; 2D NMR; Benzimidazol

1D AND 2D NMR STUDIES OF BENZYL O–VANILLIN

The reaction of o-vanillin A with benzyl bromide B2 in acetone as the solvent and K2CO3 as a base in the presence of tetra-n-butylammonium iodide (TBAI) as catalyst formed benzyl o-vanillin, C. The complete assignments of C using PROTON, APT, DEPT-135, COSY, NOESY, HMQC and HMBC NMR in both CDCl3 and acetone-d6 are discussed, and the coupling constants J are reported in Hertz (Hz).     Keywords: 1H NMR; 13C NMR; 2D NMR; Benzyl o-Vanilli

Bis[tris(pyridin-2-yl)amine]iron(II) tris(dicyanomethylidene)methanediide

FS gratefully acknowledges the Algerian MESRS (Ministere de l’Enseignement Superieur et de la Recherche Scientifique), the DGRSDT (Direction Generale de la Recherche Scientifique et du Developpement Technologique), as well as the Universite Ferhat Abbas Setif 1 for financial support.In the title compound, [Fe{(C5H4N)3N}2][C{C(CN)2}3], both ions lie across centres of inversion, with the anion being statistically disordered over two sets of atomic sites having equal occupancy. The cation and anion have approximate 3 and 32 symmetry, respectively, and the Fe---N bond lengths indicate low-spin FeII. A combination of two-centre C—H···N and three-centre C—H···(N)2 hydrogen bonds link the ions into complex sheets. Several low-occupancy water molecules are present, whose H atoms could not be located: accordingly, the reflection data were subjected to the SQUEEZE procedure [Spek (2015). Acta Cryst. C71, 9-18].Publisher PDFPeer reviewe

Synthesis, NMR spectroscopy and crystal structures studies of 2-amino-N-(2-hydroxy-3-methoxybenzylidene) aniline

The reaction of o–vanillin 1 with o-phenylenediamine 2PD, in dichloromethane at low conditions produced novel amino benzeneamine: 2-amino-N-(2-hydroxy-3-methoxybenzylidene) aniline 2. Intermediate 2 is isolated and obtained as single crystals and the structure was determined and studied by x-ray crystallography. The complete assignments of 2 were made using FTIR, HRMS, 1D and 2D NMR including APT, COSY, HMQC and HMBC in CDCl3 and will be discussed

Synthesis, NMR spectroscopy and crystal structures studies of novel 2-amino-N-(2-benzyloxy-3-methoxybenzylidene) aniline

The reaction of benzyl o-vanillin 1 with ophenylenediamine 2PD, in dichloromethane at low conditions produced novel amino benzeneamine: 2-amino-N-(2-benzyloxy-3- methoxybenzylidene) benzeneamine 2. The intermediate 2 is isolated and obtained as single crystals and their structures were determined and studied by x-ray crystallography. The complete assignments of 2 were made using FTIR, HRMS, 1D and 2D NMR including 13C, COSY, HMQC and HMBC in CDCl3 and will be discussed