An overview of the trend of research in nursing patients with uterine cancer who had undergone surgery and future research subjects

本研究の目的は,1994年～2003年9月までに発表された手術を経験する子宮がん患者の看護実践領域における研究について,文献件数および研究領域の観点からその動向を概観し,今後の研究課題を明らかにすることである。JMED,CINAHL,MEDLINEの3つを文献情報データベースとして用い,｢子宮がん｣and｢看護｣and｢子宮摘出術｣および｢uterine cancer｣and｢nursing｣and｢hysterectomy｣の検索式により文献集合を絞り,原著論文に限って検討した｡その結果,以下の9つの課題, 1)行った研究を誌上発表する 2)子宮がんの早期発見･予防,ターミナル期に焦点を当てた研究 3)術後合併症に注目した研究 4)患者のもつ力に注目し,それを引き出し,高めていくことを支援する看護に関する研究 5)術後のセクシュアリティに関連した研究 6)退院指導プログラムの開発およびクリティカル･パスの作成 7)子宮がん患者の自己効力感に関連した研究 8)cancer survivorに関する研究 9)介入研究,が明らかになった｡The purpose of this study was to review the literature on nursing patients with uterine cancer who had undergone surgery reported from 1994 through September 2003 and to elucidate future research subjects to be investigated. With three databases of literature information, JMED, CINAHL, and MEDLINE, only original papers were selected with the keywords of "uterine cancer", "nursing", and "hysterectomy". In consequence, Nine future research subjects were identified. They are as follows, 1) publishing our research, 2) research focused on early-detection and protection, and terminal phase of uterine cancer, 3) research focused on postoperative complication, 4) research about nursing to find, lead and progress abilities of patients, 5) research about sexuality after operation, 6) development of discharge-guiding program and critical pass, 7) research about self-efficacy of patients with uterine cancer, 8) research about cancer survivor, 9) intervening research

Study on the difficulties experienced in daily life by esophageal cancer patients who underwent esophagectomy

本研究の目的は,食道がん切除術を受け,自宅で生活する患者が直面している生活上の困難及びそれらへの対処の実態を明らかにすることである｡対象は,研究参加へ同意が得られた12名の外来通院中の患者とした｡対象12名の食道再建経路は, 6名が胸壁前皮下経路,6名が後縦隔経路であった｡患者の許可を得て録音した面接内容を逐語訳し,内容分析の手法を用いて質的･帰納的分析を行った｡その結果,患者は術式に関係なく,【予想をはるかに超えて苦痛と化した摂食行動】および【生活圏の狭小化】の2つの困難を抱えていることが明らかとなった｡患者は,前者には≪生きるために自分に見合った食べ方を体得する≫ ことで,後者には,≪命と引き換えに変化を受け入れる≫≪時間をかけて変化に慣れる≫ ことで対処し,術後の生活を再構築していた。The purpose of this study is to clarify the difficulties faced in daily life by patients who have undergone esophagectomy due to esophageal cancer and now reside at home, as well as the actual conditions how to cope with such difficulties. 12 patients gave their consent to participate in the study, and semi-structured interview was conducted using open-ended questions. 6 of them had undergone reconstruction of the esophagus via the subcutaneous route anterior to the thoracic wall, and the other 6 via the posterior mediastinal route. The contents of the recorded interviews were transcribed into verbatim record, and a qualitative, inductive analysis was conducted using the content analysis method. As a result, it was found that the patients were suffering from two difficulties: "that eating activities had become a far greater hardship than had been expected" and "the narrowing of social life". Patients experiencing the former difficulty dealt with it by "learning eating methods suited to them personally in order to survive" and patients experiencing the latter difficulty dealt with it by "accepting the change to save their life" or "becoming accustomed to the change slowly", and then restructure their postoperative lives

Involvement of Propionibacterium acnes in the Augmentation of Lipogenesis in Hamster Sebaceous Glands In Vivo and In Vitro

Propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, but it remains unclear whether P. acnes directly influences lipogenesis in sebaceous glands. In this study, we showed that a culture medium of P. acnes (acnes-CM) and formalin-killed P. acnes (F-acnes) prepared from P. acnes strains, JCM6473 and JCM6425, intracellularly augmented lipid droplet formation and triacylglycerol (TG) synthesis in undifferentiated and insulin-differentiated hamster sebocytes. Acnes-CM and F-acnes prepared from four clinical P. acnes strains elicited the same lipogenesis augmentation. The augmented TG production resulted from an increase in the diacylglycerol acyltransferase activity. Topical application of acnes-CM to the skin of hamster auricles every day for 4 weeks revealed that sebum accumulation was augmented in sebaceous glands and ducts. Furthermore, both acnes-CM and F-acnes increased the production of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a cytochrome P450 (CYP)-linked sebaceous lipogenic factor, in differentiated sebocytes. A CYP inhibitor, SKF-525A, decreased the acnes-CM- and F-acnes-augmented production of TG and 15d-PGJ2. Thus, to our knowledge these results provide previously unreported evidence that P. acnes directly participates in the augmentation of sebaceous lipogenesis through a proposed mechanism in which an increase of 15d-PGJ2 production through the CYP pathway is closely associated with the enhancement of TG production

Treatment for a non-compliant patient with cancer and epilepsy

　A 58-year-old man with cervical esophageal cancer and a history of epilepsy was treated with chemoradiotherapy from May of 2013. When tube feeding was initiated due to aspiration pneumonitis, the patient showed a degree of irritability that affected routine staff work and treatment compliance. We attempted to perform supportive care for maladjustment by the notice, the fast, and the tube feeding, but there was no improvement. After we added carbamazepine, primidone, and propericiazine (which had been canceled at the initiation of the tube feeding) to the patient's intravenous phenytoin, the symptoms and treatment compliance improved significantly. We concluded that the causes of the patient's irritability were maladjustment and his epilepsy

An external quality assessment feasibility study; cross laboratory comparison of haemagglutination inhibition assay and microneutralization assay performance for seasonal influenza serology testing: A FLUCOP study

Introduction: External Quality Assessment (EQA) schemes are designed to provide a snapshot of laboratory proficiency, identifying issues and providing feedback to improve laboratory performance and inter-laboratory agreement in testing. Currently there are no international EQA schemes for seasonal influenza serology testing. Here we present a feasibility study for conducting an EQA scheme for influenza serology methods. Methods: We invited participant laboratories from industry, contract research organizations (CROs), academia and public health institutions who regularly conduct hemagglutination inhibition (HAI) and microneutralization (MN) assays and have an interest in serology standardization. In total 16 laboratories returned data including 19 data sets for HAI assays and 9 data sets for MN assays. Results: Within run analysis demonstrated good laboratory performance for HAI, with intrinsically higher levels of intra-assay variation for MN assays. Between run analysis showed laboratory and strain specific issues, particularly with B strains for HAI, whilst MN testing was consistently good across labs and strains. Inter-laboratory variability was higher for MN assays than HAI, however both assays showed a significant reduction in inter-laboratory variation when a human sera pool is used as a standard for normalization. Discussion: This study has received positive feedback from participants, highlighting the benefit such an EQA scheme would have on improving laboratory performance, reducing inter laboratory variation and raising awareness of both harmonized protocol use and the benefit of biological standards for seasonal influenza serology testing.publishedVersio

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray

The Quiescent Intracluster Medium in the Core of the Perseus Cluster

Clusters of galaxies are the most massive gravitationally-bound objects in the Universe and are still forming. They are thus important probes of cosmological parameters and a host of astrophysical processes. Knowledge of the dynamics of the pervasive hot gas, which dominates in mass over stars in a cluster, is a crucial missing ingredient. It can enable new insights into mechanical energy injection by the central supermassive black hole and the use of hydrostatic equilibrium for the determination of cluster masses. X-rays from the core of the Perseus cluster are emitted by the 50 million K diffuse hot plasma filling its gravitational potential well. The Active Galactic Nucleus of the central galaxy NGC1275 is pumping jetted energy into the surrounding intracluster medium, creating buoyant bubbles filled with relativistic plasma. These likely induce motions in the intracluster medium and heat the inner gas preventing runaway radiative cooling; a process known as Active Galactic Nucleus Feedback. Here we report on Hitomi X-ray observations of the Perseus cluster core, which reveal a remarkably quiescent atmosphere where the gas has a line-of-sight velocity dispersion of 164+/-10 km/s in a region 30-60 kpc from the central nucleus. A gradient in the line-of-sight velocity of 150+/-70 km/s is found across the 60 kpc image of the cluster core. Turbulent pressure support in the gas is 4% or less of the thermodynamic pressure, with large scale shear at most doubling that estimate. We infer that total cluster masses determined from hydrostatic equilibrium in the central regions need little correction for turbulent pressure.Comment: 31 pages, 11 Figs, published in Nature July

Hitomi (ASTRO-H) X-ray Astronomy Satellite

The Hitomi (ASTRO-H) mission is the sixth Japanese x-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E  >  2  keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft x-rays to gamma rays. After a successful launch on February 17, 2016, the spacecraft lost its function on March 26, 2016, but the commissioning phase for about a month provided valuable information on the onboard instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month