The time course of cancer detection performance

The purpose of this study was to measure how mammography readers' performance varies with time of day and time spent reading. This was investigated in screening practice and when reading an enriched case set. In screening practice records of time and date that each case was read, along with outcome (whether the woman was recalled for further tests, and biopsy results where performed) was extracted from records from one breast screening centre in UK (4 readers). Patterns of performance with time spent reading was also measured using an enriched test set (160 cases, 41% malignant, read three times by eight radiologists). Recall rates varied with time of day, with different patterns for each reader. Recall rates decreased as the reading session progressed both when reading the enriched test set and in screening practice. Further work is needed to expand this work to a greater number of breast screening centres, and to determine whether these patterns of performance over time can be used to optimize overall performance

Additional file 1: of How are evidence and knowledge used in orthopaedic decision-making? Three comparative case studies of different approaches to implementation of clinical guidance in practice

An example of a NICE guidance recommendation. Technology appraisal guidance [TA304] [17]. Total hip replacement and resurfacing arthroplasty for end-stage arthritis of the hip. Interview topic guide. (DOCX 15 kb

Spatial distribution of the 100 most frequently cited systematic reviews and meta-analyses related articles using density equalizing mapping.

<p>The area of each country were re-sized in proportion to its total number of 100 most frequently cited systematic reviews and meta-analyses related articles. </p

Graph demonstrating the time period of publication of the 100 most cited systematic reviews and meta-analyses related articles.

<p>Graph demonstrating the time period of publication of the 100 most cited systematic reviews and meta-analyses related articles.</p

Correlation between since publication, number of authors, journals’ impact factor and average citation per year.

<p>Correlation between since publication, number of authors, journals’ impact factor and average citation per year.</p

Network of studies comparing effectiveness (OS, PFS) and safety (grade 3–5 drug-related AE) outcomes in all-histology NSCLC.

<p>Network of studies comparing effectiveness (OS, PFS) and safety (grade 3–5 drug-related AE) outcomes in all-histology NSCLC.</p

Implant dislocation of cemented cup vs. cementless cup.

<p>Implant dislocation of cemented cup vs. cementless cup.</p

Additional file 1: of Cost and quality of life analysis of HIV self-testing and facility-based HIV testing and counselling in Blantyre, Malawi

Appendix A. Direct health provider costing methods. Appendix B. Sensitivity Analysis for multivariate regression of total societal cost (Model 2). (DOCX 48 kb

Mean post Harris hip score measured at follow up.

<p>Mean post Harris hip score measured at follow up.</p

Additional file 1: Table S1. of Evaluation of pre-symptomatic nitisinone treatment on long-term outcomes in Tyrosinemia type 1 patients: a systematic review

Search strategy for Ovid Medline. This table shows the electronic search strategy developed for Medline (Ovid) and the number of hits retrieved per line. Figure S1. EPHPP quality assessment tool for quantitative studies. This file shows the EPHPP “Quality assessment tool for quantitative studies” that was used to appraise the quality of all included studies. Table S2. Excluded studies with reason. This table lists all studies that were excluded at full text stage and reasons for their exclusion. (DOCX 126 kb